In Vivo Effect of β2-Microglobulin on Bone Resorption

Simultaneous multiple tendon ruptures complicating a seizure in a haemodialysis patient

“…In three patients with spontaneous tendon avulsions repaired surgically, there was no evidence of dialysis‐related amyloid in the tendon specimens 1,5 . Although local injection of β 2 microglobulin caused increased periosteal bone reabsorption 4 in an animal model, the relationship between the serum concentration of β 2 microglobulin and tissue injury resulting from amyloidosis in dialysis patients is yet to be established.…”

“…Radiological evidence of secondary hyperparathyroidism has been reported as present in 74% of dialysis cases with tendon rupture 1 . Parathyroid hormone has been shown to increase bone resorption at the periosteum and bone marrow interface, suggesting increased osteoclastic activity 4 . A retrospective analysis of dialysis patients with a tendon rupture demonstrated marked bone erosions at the site of tendon insertion prior to tendon injury 3 .…”

“…1 Parathyroid hormone has been shown to increase bone resorption at the periosteum and bone marrow interface, suggesting increased osteoclastic activity. 4 A retrospective analysis of dialysis patients with a tendon rupture demonstrated marked bone erosions at the site of tendon insertion prior to tendon injury. 3 Histological examination of the ruptured tendons from three patients with secondary hyperparathyroidism showed minute bone fragments adjacent to the tendon.…”

“…The aetiology of tendon rupture is controversial and many factors have been proposed. These factors include younger age, 1 duration on dialysis, 1,3 β 2 microglobulin‐related amyloidosis, 2,4 hyperparathyroidism, 1,3,5–7 chronic tissue acidosis, 8 previous use of corticosteroids 1 and fluoroquinolone antibiotics 1 . We present a case of multiple large tendon ruptures occurring in a patient on long‐term haemodialysis following generalized epileptiform seizures, and review the current literature on the pathophysiology of this complication.…”

β₂-Microglobulin Dialysis Amyloid and Its Formation: Role of 3-Deoxyglucosone and Advanced Glycation End Products

“…A large extravascular pool of p2M in dialysis patients contributes to the development of dialysis-related amy loidosis [114], However, there is no significant correlation between the plasma level of (32M and the occurrence of dialysis-related amyloidosis [124], while the serum levels o fa 2-macroglobulin are elevated in patients with dialysisrelated amyloidosis as compared with control dialysis patients without dialysis-related amyloidosis [125], In vivo study using mice demonstrated that p2M caused bone resorption in the bone surfaces proximate to the site of p2M injection, suggesting the role of p2M in the devel opment of bone cysts [126].…”