In vivo Effect of Zinc on Iron Turnover in Rats and Life Span of the Erythrocyte

Settlemire, C. T.; Matrone, Gennard

doi:10.1093/jn/92.2.159

Cited by 36 publications

(8 citation statements)

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“…Mahloudji A high level of zinc supplementation may also affect iron storage. Toxic levels of zinc in the diet may shorten the life-span of red blood cells and cause anemia because of the faster iron turnover (243). Zinc is known to interfere with iron uptake by the liver so that there is a decrease in the storage of iron as ferritin (244).…”

Section: Interactions With Other Metalsmentioning

confidence: 99%

Zinc: Health Effects and Research Priorities for the 1990s

Walsh¹,

Sandstead²,

Prasad³

et al. 1994

Environmental Health Perspectives

156

225

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This review critically summarizes the literature on the spectrum of health effects of zinc status, ranging from symptoms of zinc deficiency to excess exposure. Studies on zinc intake are reviewed in relation to optimum requirements as a function of age and sex. Current knowledge on the biochemical properties of zinc which are critical to the essential role of this metal in biological systems is summarized. Dietary and physiological factors influencing the bioavailability and utilization of zinc are considered with special attention to interactions with iron and copper status. The effects of zinc deficiency and toxicity are reviewed with respect to specific organs, immunological and reproductive function, and genotoxicity and carcinogenicity. Finally, key questions are identified where research is needed, such as the risks to human health of altered environmental distribution of zinc, assessment of zinc status in humans, effects of zinc status in relation to other essential metals on immune function, reproduction, neurological function, and the cardiovascular system, and mechanistic studies to further elucidate the biological effects of zinc at the molecular level. - There is considerable evidence that zinc deficiency in humans is a serious worldwide problem and outweighs the potential problem of accidental, self-imposed, or environmental exposure to zinc excess. Acute deficiency (1) and chronic deficiency (2) are well-known entities in human populations and are probably much more common than generally recognized. The importance of zinc for human health was first documented in 1963 (3) Telephone (617) (617) 638-4329. E-mail: ctwalsh~bu.edu renal disease, and other chronically debilitating diseases are now known to be predisposing factors for zinc deficiency in humans (4).Zinc deficiency is reflected in clinical syndromes which affect men and women of all ages and all socioeconomic and cultural classes in the United States. It is neither prevalent in any specific area of the United States nor associated with any specific or definitive biochemical marker, which can make its identification difficult and confusing. Its presence is manifested by a wide spectrum of symptoms, from acute, life threatening problems to mild subclinical or marginal disorders which may only vaguely disturb well being. The acute problems are often seen in profoundly ill patients treated in hospitals, whereas subclinical problems may be so vague that patients seek assistance outside traditional medical practice.Based upon clinical data and using traditional, epidemiologic techniques, Henkin and Aamodt (5) have reclassified zinc deficiency into three syndromes; these are a) acute, b) chronic, and c) subacute zinc deficiency. Acute zinc deficiency is relatively uncommon and follows parenteral hyperalimentation or oral L-histidine administration. Chronic zinc deficiency is more common, usually resulting from chronic dietary lack of zinc. Subacute or latent zinc deficiency is the most common of these syndromes. It is estimated that there are 4...

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Section: Interactions With Other Metalsmentioning

confidence: 99%

Zinc: Health Effects and Research Priorities for the 1990s

Walsh¹,

Sandstead²,

Prasad³

et al. 1994

Environmental Health Perspectives

156

225

View full text Add to dashboard Cite

show abstract

“…Iron tracer doses were separated by 3 d to allow sufficient time for the intestinal epithelium to renew in order to minimize any impact of the first tracer dose on absorption of the second tracer dose. Absorption of the heme and nonheme tracers was assessed by RBC enrichment 10 d after the administration of the second tracer because previous iron tracer studies in rats have established that RBC incorporation of injected iron is complete within 6 d of administration (19,20). Rats were anesthetized by using 30% (v/v) isoflurane and killed by exsanguination.…”

Section: Methodsmentioning

confidence: 99%

Duodenal Absorption and Tissue Utilization of Dietary Heme and Nonheme Iron Differ in Rats

Cao

Thomas

Insogna

et al. 2014

The Journal of Nutrition

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“…Toxic levels of zinc in the diet may shorten the life span of red blood cells and cause anemia because of the faster iron turnover (Settlemire and Matrone, 1967a). Zinc is known to interfere with iron uptake by the liver so that there is a decrease in the storage of iron as ferritin (Settlemire and Matrone, 1967b ).…”

Section: Interactions Of Zinc and Iron In Humansmentioning

confidence: 99%

Interactions of Zinc with Other Micronutrients

Prasad

1993

Biochemistry of Zinc

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In vivo Effect of Zinc on Iron Turnover in Rats and Life Span of the Erythrocyte

Cited by 36 publications

References 0 publications

Zinc: Health Effects and Research Priorities for the 1990s

Zinc: Health Effects and Research Priorities for the 1990s

Duodenal Absorption and Tissue Utilization of Dietary Heme and Nonheme Iron Differ in Rats

Interactions of Zinc with Other Micronutrients

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