In vivo effect of snake phospholipase A2 (crotoxin+cardiotoxin) on serum IL-1α, TNF-α and IL-1ra level in humans

Costa, Luís; Fornari, María Cecilia; Berardi, Vanina E.; Miles, Horacio A.; Díez, Roberto A.

doi:10.1016/s0165-2478(00)00293-5

Cited by 14 publications

(9 citation statements)

References 23 publications

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“…Addition of cardiotoxin dissociates cytotoxicity (required for antitumoral activity) and neurotoxicity (otherwise, its main side effect) and allows a useful concentration to be achieved in vivo [107]. Injection of crotoxin into mice has been reported to increase the in vivo production of tumor necrosis factor α (TNF- α ) together with the stimulation of the hypothalamic-pituitary axis [108]. …”

Section: Snake Venom Phospholipases A2 (Svpla2s)mentioning

confidence: 99%

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Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy

Calderon

Sobrinho

Zaqueo

et al. 2014

BioMed Research International

155

142

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For more than half a century, cytotoxic agents have been investigated as a possible treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues and cell cultures, both normal and tumoral. Snake venoms show the highest cytotoxic potential, since ophidian accidents cause a large amount of tissue damage, suggesting a promising utilization of these venoms or their components as antitumoral agents. Over the last few years, we have studied the effects of snake venoms and their isolated enzymes on tumor cell cultures. Some in vivo assays showed antineoplastic activity against induced tumors in mice. In human beings, both the crude venom and isolated enzymes revealed antitumor activities in preliminary assays, with measurable clinical responses in the advanced treatment phase. These enzymes include metalloproteases (MP), disintegrins, L-amino acid oxidases (LAAOs), C-type lectins, and phospholipases A2 (PLA2s). Their mechanisms of action include direct toxic action (PLA2s), free radical generation (LAAOs), apoptosis induction (PLA2s, MP, and LAAOs), and antiangiogenesis (disintegrins and lectins). Higher cytotoxic and cytostatic activities upon tumor cells than normal cells suggest the possibility for clinical applications. Further studies should be conducted to ensure the efficacy and safety of different snake venom compounds for cancer drug development.

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Section: Snake Venom Phospholipases A2 (Svpla2s)mentioning

confidence: 99%

“…Costa et al [108] evaluated the probable mechanism of action of this union and concluded that PLA 2 s act on the receptors of the epidermal growth factor. Another route of action might be a decreased production of tumor necrosis factor.…”

Section: Snake Venom Phospholipases A2 (Svpla2s)mentioning

confidence: 99%

Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy

Calderon

Sobrinho

Zaqueo

et al. 2014

BioMed Research International

155

142

View full text Add to dashboard Cite

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“…By these or other mechanisms, crotoxin interferes with the signaling of epidermal growth factor receptor. The addition of cardiotoxin dissociates cytotoxicity (required for antineoplastic activity) and neurotoxicity (otherwise, its main side effect) and allows useful concentration to be achieved in vivo [44].…”

Section: Antitumor Activity Of Snake Venoms Toxinsmentioning

confidence: 99%

Snake Venom Phospholipases A2: A New Class of Antitumor Agents

Rodrigues

Izidoro²,

Oliveira³

et al. 2009

PPL

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Phospholipases A(2) (PLA(2)) are enzymes of high medical scientific interest due to their involvement in a large number of human inflammatory diseases. PLA(2) constitute a diverse family of enzymes which catalyses the hydrolysis of the sn-2 ester bond in glycerophospholipids and exhibit a wide range of physiological and pathological effects. The ubiquitous nature of PLA(2) highlights the important role they play in many biological processes, as cell signaling and cell growth, including the generation of proinflammatory lipid mediators such as prostaglandin and leukotrienes, regulation of lipid mediators. The activity and expression of several PLA(2) isoforms are increased in several human cancers, suggesting that these enzymes have a central role in both tumor development and progression and can be targets for anti-cancer drugs. On the other hand, some PLA(2) isolated from Viperidae venoms are capable to induce antitumoral activity. In summary PLA(2) from snake venoms can be a new class of anticancer agents and provide new molecular and biological insights of cancer development.

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“…Já o polipeptídio básico (CB) de 14 kDa, conhecido também por fosfolipase A2 (PLA2), possui toxicidade e uma forte atividade enzimática (FRAENKEL-CONRAT; HENDON, 1971;RUBSAMEN et al, 1971). A subunidade CA tem função de chaperona ao carrear a subunidade PLA2 para seu receptor na membrana celular, onde há dissociação das subunidades e ação efetora desta segunda fração (BON et al, 1988;COSTA et al, 2001).…”

Section: Características Gerais Da Crotoxina Do Veneno De Crotalus Duunclassified

Estudo da imunomodulação induzida pela crotoxina do veneno de Crotalus durissus terrificus em modelo experimental de doença inflamatória no intestino.

Almeida¹

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In vivo effect of snake phospholipase A2 (crotoxin+cardiotoxin) on serum IL-1α, TNF-α and IL-1ra level in humans

Cited by 14 publications

References 23 publications

Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy

Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy

Snake Venom Phospholipases A2: A New Class of Antitumor Agents

Estudo da imunomodulação induzida pela crotoxina do veneno de Crotalus durissus terrificus em modelo experimental de doença inflamatória no intestino.

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