In vivo effect of UV‐photofunctionalization of CoCrMo in processes of guided bone regeneration and tissue engineering

Abstract

Photofunctionalization of implant materials with ultraviolet (UV) radiation have been subject of study in the last two decades, and previous research on CoCrMo discs have showed good results in terms of bioactivity and the findings of apatite-like crystals in vitro. In the current study, CoCrMo domes were photofunctionalized with UV radia

Close-to-native bone repair via tissue-engineered endochondral ossification approaches

“… Zuchuat et al. 173 Cobalt–chromium–molybdenum alloy Photofunctionalization with UV-C irradiation 6 weeks The results obtained by X-ray, micro-CT analysis, and H&E histology showed evidence of bone formation by ECO. Lin et al.…”

Osteogenic activity of bone: Novel approach of polyvinylidene fluoride films, marrow blood supply, and ultrasound stimulation

“…The fabrication and use of the CoCr dome had been previously demonstrated and used by our research group. 22 The PVDF films underwent sterilization using ethylene oxide (ETO; gas phase: 10% ETO, 44 C, 65% relative humidity, 1.7 bar, gas exposure time: 3 h, aeration phase: 24 h) due to their sensitivity to temperatures exceeding 60 C, as per literature recommendations. 28 On the other hand, CoCr domes and screws were sterilized using an autoclave.…”

“…These biomaterials provide an adequate space for volume expansion and mechanical stability for new bone formation and acting as scaffolds for ingrowth of osteoblasts, 21‐23 including space maintenance to prevent soft tissue invasion thus protecting bone regenerative compartment during native bone healing. The concept of guided tissue regeneration is used as a stand‐alone or in combination with other materials like Cobalt based alloys 22‐24 . It is mainly associated with the repair of intrabony defects 25 .…”

“…19,20 On the other hand, the use of rigid barriers to enhance the growth of bone tissue and to create a stable volume or osteoprogenitor cell colonization, have been widely investigated, and various osteoconductive biomaterials have been evaluated for bone regeneration purposes. These biomaterials provide an adequate space for volume expansion and mechanical stability for new bone formation and acting as scaffolds for ingrowth of osteoblasts, [21][22][23] including space maintenance to prevent soft tissue invasion thus protecting bone regenerative compartment during native bone healing. The concept of guided tissue regeneration is used as a stand-alone or in combination with other materials like Cobalt based alloys.…”

“…The concept of guided tissue regeneration is used as a stand-alone or in combination with other materials like Cobalt based alloys. [22][23][24] It is mainly associated with the repair of intrabony defects. 25 Nevertheless, preclinical studies investigating the use of guided bone regeneration techniques for extracortical bone growth have shown modest levels of success.…”