In vivo dynamic optical coherence elastography using a ring actuator

Kennedy, Brendan F.; Hillman, Timothy R.; McLaughlin, Robert A.; Quirk, Bryden C.; Sampson, David D.

doi:10.1364/oe.17.021762

Cited by 135 publications

(130 citation statements)

References 34 publications

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“…The thickness assessment of different layers of bladder has potential to aid the diagnosis of bladder pathological conditions which related to layer thickness change. The results estimated from the phase velocity curves can be cross-validated using vibration optical coherence elastography (OCE) [46][47][48][49], as shown in Fig. 6(a) and 6(b).…”

Section: Bladder Wall Elasticity Measurementmentioning

confidence: 99%

Quantitative elasticity measurement of urinary bladder wall using laser-induced surface acoustic waves

Guan

Zhang

et al. 2014

Biomed. Opt. Express

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Abstract:The maintenance of urinary bladder elasticity is essential to its functions, including the storage and voiding phases of the micturition cycle. The bladder stiffness can be changed by various pathophysiological conditions. Quantitative measurement of bladder elasticity is an essential step toward understanding various urinary bladder disease processes and improving patient care. As a nondestructive, and noncontact method, laserinduced surface acoustic waves (SAWs) can accurately characterize the elastic properties of different layers of organs such as the urinary bladder. This initial investigation evaluates the feasibility of a noncontact, all-optical method of generating and measuring the elasticity of the urinary bladder. Quantitative elasticity measurements of ex vivo porcine urinary bladder were made using the laser-induced SAW technique. A pulsed laser was used to excite SAWs that propagated on the bladder wall surface. A dedicated phase-sensitive optical coherence tomography (PhS-OCT) system remotely recorded the SAWs, from which the elasticity properties of different layers of the bladder were estimated. During the experiments, series of measurements were performed under five precisely controlled bladder volumes using water to estimate changes in the elasticity in relation to various urinary bladder contents. The results, validated by optical coherence elastography, show that the laser-induced SAW technique combined with PhS-OCT can be a feasible method of quantitative estimation of biomechanical properties. 1768-1778 (1999). 3. T. Watanabe, S. Omata, J. Z. Lee, and C. E. Constantinou, "Comparative analysis of bladder wall compliance based on cystometry and biosensor measurements during the micturition cycle of the rat," Neurourol. Urodyn. 16(6), 567-581 (1997). 4. A. Elbadawi, S. V. Yalla, and N. M. Resnick, "Structural basis of geriatric voiding dysfunction. IV. Bladder outlet obstruction," J. Urol. 150(5 Pt 2), 1681-1695 (1993). 5. L. M. Liao and W. Schaefer, "Cross-sectional and longitudinal studies on interaction between bladder compliance and outflow obstruction in men with benign prostatic hyperplasia," Asian J. Androl. 9(1), 51-56 (2007 418-426 (2012). 10. K. Sabanathan, H. M. Duffin, and C. M. Castleden, "Urinary tract infection after cystometry," Age Ageing 14(5), 291-295 (1985). 11. N. N. Bhatia and A. Bergman, "Cystometry: unstable bladder and urinary tract infection," Br. J. Urol. 58(2), 134-137 (1986) 21-29 (1994). 54. F. F. Chai and T. T. Wu, "Determination of anisotropic elastic constants using laser-generated surface waves," J. ©2014 Optical Society of AmericaAcoust. Soc. Am. 95(6), 3232-3241 (1994

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Section: Bladder Wall Elasticity Measurementmentioning

confidence: 99%

Quantitative elasticity measurement of urinary bladder wall using laser-induced surface acoustic waves

Guan

Zhang

et al. 2014

Biomed. Opt. Express

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“…General OCE techniques employ a loading device to induce tissue deformation and utilize OCT-based displacement-detection technique to monitor the dynamic response of the tissue [34][35][36]. The feasibilities of using OCE for three-dimensional elastic imaging [37,38], in vivo detection [39][40][41] and Young's modulus measurement [42][43][44] have been demonstrated on tissue-mimicking phantoms and different types of biological tissues, such as skin and soft-tissue tumor.…”

Section: Introductionmentioning

confidence: 99%

Noncontact depth-resolved micro-scale optical coherence elastography of the cornea

Wang

Larin

2014

Biomed. Opt. Express

155

129

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High-resolution elastographic assessment of the cornea can greatly assist clinical diagnosis and treatment of various ocular diseases. Here, we report on the first noncontact depth-resolved micro-scale optical coherence elastography of the cornea achieved using shear wave imaging optical coherence tomography (SWI-OCT) combined with the spectral analysis of the corneal Lamb wave propagation. This imaging method relies on a focused air-puff device to load the cornea with highly-localized lowpressure short-duration air stream and applies phase-resolved OCT detection to capture the low-amplitude deformation with nano-scale sensitivity. The SWI-OCT system is used here to image the corneal Lamb wave propagation with the frame rate the same as the OCT A-line acquisition speed. Based on the spectral analysis of the corneal temporal deformation profiles, the phase velocity of the Lamb wave is obtained at different depths for the major frequency components, which shows the depthwise distribution of the corneal stiffness related to its structural features. Our pilot experiments on ex vivo rabbit eyes demonstrate the feasibility of this method in depth-resolved micro-scale elastography of the cornea. The assessment of the Lamb wave dispersion is also presented, suggesting the potential for the quantitative measurement of corneal viscoelasticity. 3026-3031 (2007). 3. L. T. Nordan, "Keratoconus: diagnosis and treatment," Int. Ophthalmol. Clin. 37(1), 51-63 (1997). 4. C. Edmund, "Corneal elasticity and ocular rigidity in normal and keratoconic eyes," Acta Ophthalmol. (Copenh.) 66(2), 134-140 (1988 Biol. 93(1-3), 176-191 (2007). 17. G. Scarcelli and S. H. Yun, "Confocal Brillouin microscopy for three-dimensional mechanical imaging," Nat. ©2014 Optical Society of AmericaPhotonics 2(1), 39-43 (2008). 18. J. Schmitt, "OCT elastography: imaging microscopic deformation and strain of tissue," Opt. Express 3(6), 199-211 (1998). 19. G. Scarcelli and S. H. Yun, "In vivo Brillouin optical microscopy of the human eye," Opt. Express 20(8), 9197-9202 (2012). 20. G. Scarcelli, R. Pineda, and S. H. Yun, "Brillouin optical microscopy for corneal biomechanics," Invest.Ophthalmol. Vis. Sci. 53(1), 185-190 (2012). 21. G. Scarcelli, S. Kling, E. Quijano, R. Pineda, S. Marcos, and S. H. Yun, "Brillouin microscopy of collagen crosslinking: noncontact depth-dependent analysis of corneal elastic modulus," Invest. Ophthalmol. Vis. Sci.

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“…Development and modifications to the hardware, electronics, and software of an existing multi-axis microrobot are detailed. Linear dynamic and Wiener static nonlinear stochastic system identification protocols have been adapted to a device that is more versatile than those used in previous dynamic skin studies [21,23,24,[30][31][32][33][34][35]. Stochastic system identification was applied to the volar forearm and thenar eminence, the latter being a location for which there was little dynamic data.…”

Section: Discussionmentioning

confidence: 99%

“…The estimates of skin properties can be affected by the level of preload on the skin, which can place the local perturbations at an unknown location along the full-scale force-displacement curve. In addition, very few deformation devices have attempted to characterize the dynamic properties of skin [20][21][22][23][24][25], with the majority opting to minimize viscous effects by perturbing at quasi-static rates. A device that can perturb skin throughout its nonlinear stress-strain curve, at varying rates, may provide the basis for standardized testing of skin.…”

Section: Introductionmentioning

confidence: 99%

Multidirectional In Vivo Characterization of Skin Using Wiener Nonlinear Stochastic System Identification Techniques

Parker

Jones

Hunter

et al. 2016

Journal of Biomechanical Engineering

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A triaxial force-sensitive microrobot was developed to dynamically perturb skin in multiple deformation modes, in vivo. Wiener static nonlinear identification was used to extract the linear dynamics and static nonlinearity of the force-displacement behavior of skin. Stochastic input forces were applied to the volar forearm and thenar eminence of the hand, producing probe tip perturbations in indentation and tangential extension. Wiener static nonlinear approaches reproduced the resulting displacements with variances accounted for (VAF) ranging 94-97%, indicating a good fit to the data. These approaches provided VAF improvements of 0.1-3.4% over linear models. Thenar eminence stiffness measures were approximately twice those measured on the forearm. Damping was shown to be significantly higher on the palm, whereas the perturbed mass typically was lower. Coefficients of variation (CVs) for nonlinear parameters were assessed within and across individuals. Individual CVs ranged from 2% to 11% for indentation and from 2% to 19% for extension. Stochastic perturbations with incrementally increasing mean amplitudes were applied to the same test areas. Differences between full-scale and incremental reduced-scale perturbations were investigated. Different incremental preloading schemes were investigated. However, no significant difference in parameters was found between different incremental preloading schemes. Incremental schemes provided depth-dependent estimates of stiffness and damping, ranging from 300 N/m and 2 Ns/m, respectively, at the surface to 5 kN/m and 50 Ns/m at greater depths. The device and techniques used in this research have potential applications in areas, such as evaluating skincare products, assessing skin hydration, or analyzing wound healing.

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In vivo dynamic optical coherence elastography using a ring actuator

Cited by 135 publications

References 34 publications

Quantitative elasticity measurement of urinary bladder wall using laser-induced surface acoustic waves

Quantitative elasticity measurement of urinary bladder wall using laser-induced surface acoustic waves

Noncontact depth-resolved micro-scale optical coherence elastography of the cornea

Multidirectional In Vivo Characterization of Skin Using Wiener Nonlinear Stochastic System Identification Techniques

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