In vivo dynamic bone growth modulation is less detrimental but as effective as static growth modulation

Valteau, Barthélémy; Grimard, Guy; Londono, Irène; Moldovan, Florina; Villemure, Isabelle

doi:10.1016/j.bone.2011.07.008

Cited by 33 publications

(57 citation statements)

References 26 publications

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“…This work demonstrates a direct application of soft actuators in biomedical devices involving physical interaction (for example, beyond simply applying quasi-static stress to the bones, as reported in [19]). Firstly, the silicone-rubber can be shaped easily into various configurations of actuators depending on the specific application, as demonstrated in this work as well as in previous and ongoing works [3][4][5]17].…”

Section: Discussionmentioning

confidence: 79%

Soft robot for gait rehabilitation of spinalized rodents

Song

Sun

Brand

et al. 2013

2013 IEEE/RSJ International Conference on Intelligent Robots and Systems

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Soft actuators made of highly elastic polymers allow novel robotic system designs, yet application-specific soft robotic systems are rarely reported. Taking notice of the characteristics of soft pneumatic actuators (SPAs) such as high customizability and low inherent stiffness, we report in this work the use of soft pneumatic actuators for a biomedical usethe development of a soft robot for rodents, aimed to provide a physical assistance during gait rehabilitation of a spinalized animal. The design requirements to perform this unconventional task are introduced. Customized soft actuators, soft joints and soft couplings for the robot are presented. Live animal experiment was performed to evaluate and show the potential of SPAs for their use in the current and future biomedical applications.

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Section: Discussionmentioning

confidence: 79%

Soft robot for gait rehabilitation of spinalized rodents

Song

Sun

Brand

et al. 2013

2013 IEEE/RSJ International Conference on Intelligent Robots and Systems

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“…Similar to previous in vivo studies, the 0.2 MPa stress level was chosen so that it would be in a biological range that modulates the growth rate without stopping it. 3,10 Dynamic loading was applied using a sinusoidal waveform with an average compressive stress of 0.1 MPa or 0.2 MPa and with a frequency of 0.1 Hz or 1.0 Hz and an amplitude (i.e., variation around the average stress) of AE30% or AE100%. The mechanical modulation was performed for a total duration of either 12 h or 24 h over a 48 h period of culture with parameters chosen based on the group of experiment ( Fig.…”

Section: Mechanical Loading Protocolmentioning

confidence: 99%

“…Based on many clinical and experimental evidences, mechanical loading is known to be one of the factors regulating longitudinal bone growth. Longitudinal growth of long bones and vertebrae occurs by continuous calcification of newly produced cartilaginous tissue in the growth plate .…”

mentioning

confidence: 99%

“…Few in vivo and in vitro studies have previously investigated the effects of compressive static and dynamic modulation on bone growth rate, histomorphology, and protein expression . During mechanical modulation, growth plate chondrocytes undergo mechanical stimulation; they need to survive this mechanical stimulus in order to maintain their matrix integrity, which in turn will determine the resulting mechanical properties of the tissue.…”

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confidence: 99%

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Compressive mechanical modulation alters the viability of growth plate chondrocytes in vitro

Kaviani

Londono

Parent

et al. 2015

Journal Orthopaedic Research

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The aim of this study was to investigate the effect of compressive modulation parameters (mode, magnitude, duration, as well as frequency and amplitude for cyclic modulation) on the viability of growth plate chondrocytes. Swine ulnar growth plate explants (n ¼ 60) were randomly distributed among 10 groups: baseline (n ¼ 1 Â 6); culture control (n ¼ 1 Â 6); static (n ¼ 3 Â 6); and dynamic (n ¼ 5 Â 6). Static and dynamic samples were modulated in vitro using a bioreactor. Different compression magnitudes (0.1 MPa or 0.2 MPa), durations (12 h or 24 h), frequencies (0.1 Hz or 1.0 Hz), and amplitudes (30% or 100%) were investigated. Viability was assessed by automatic quantification of number of live/dead cells from confocal images of Live/Dead labeled tissues. Chondrocyte viability was found to be dependent on compression magnitude, duration, frequency, and amplitude in a way that increasing each parameter decreased viability in certain zones of growth plate. More specifically, proliferative and hypertrophic chondrocytes were found to be more sensitive to the applied compression. This study provides an in vitro protocol for studying the effects of compressive modulation on biomechanical and biological responses of growth plate explants, which will be useful in finding efficient and non-detrimental parameters for mechanical modulation of bone growth exploited in scoliosis fusionless treatments.

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“…The progression of skeletal deformities, like genu valgum/varum and adolescent idiopathic scoliosis, is related to abnormal loading of the growth plates (LeVeau and Bernhardt 1984;Villemure and Stokes 2009), where growth plates are sensitive to their mechanical environment. Growth plate sensitivity to mechanical stimuli was studied for sustained compression (Cancel et al 2009;Stokes 2002), tension (Stokes 2002;Stokes et al 2006) and cyclic loadings (Wang and Mao 2002;Valteau et al 2011). Mechanical and surgical interventions based on biomechanical principles, like braces and epiphysis stapling, rely on such information to control or reduce deformities associated with bone growth (LeVeau and Bernhardt 1984).…”

Section: Introductionmentioning

confidence: 99%

On the relevance of using homogeneous biphasic models to characterize the mechanical behavior of the growth plate

Collin

Villemure

Lévesque

2015

Mech Time-Depend Mater

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The purpose of this work was to theoretically evaluate the relevance of using homogeneous biphasic models to represent the mechanical behavior of the growth plate. To that end, representative volume elements (RVEs) of reserve and proliferative zones, where the extracellular matrix was modeled as poroelastic and the chondrocytes were assumed to be isotropic and linearly elastic, were meshed by finite elements. The matrix obeyed either the biphasic poroelastic (BPE) or the transversely isotropic biphasic poroelastic (TIBPE) models. The RVEs were submitted to unconfined compression (UC), confined compression (CC) and to a hybrid loading featuring a prescribed pore pressure. The overall responses of the RVEs to UC and CC were fit by either the BPE or the TIBPE models. The study revealed that the BPE model was unable to predict the responses under UC and CC simultaneously for both modeled zones. The TIBPE model fit with good accuracy the RVEs effective responses under UC and CC, but failed to predict the response of the hybrid loading. These results show that a mixture of poroelastic phases does not lead to an overall behavior that can be fit with the same formulation. Moreover, this study exemplified the fact the even if the TIBPE model fits experimental data under UC and CC due to its increased number of parameters, it can fail to predict other loading cases. This motivates further micromechanical studies where the local behavior of the constituent phases would carefully be evaluated.

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In vivo dynamic bone growth modulation is less detrimental but as effective as static growth modulation

Cited by 33 publications

References 26 publications

Soft robot for gait rehabilitation of spinalized rodents

Soft robot for gait rehabilitation of spinalized rodents

Compressive mechanical modulation alters the viability of growth plate chondrocytes in vitro

On the relevance of using homogeneous biphasic models to characterize the mechanical behavior of the growth plate

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