In vivo DTI longitudinal measurements of acute sciatic nerve traction injury and the association with pathological and functional changes

Li, Xinchun; Chen, Jingcong; Hong, Goubin; Sun, Congpeng; Wu, Xiaomen; Peng, Matthew Jian-Qiao; Zeng, Guangqiao

doi:10.1016/j.ejrad.2013.07.018

Cited by 34 publications

(38 citation statements)

References 24 publications

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“…One possible explanation is that severance largely increases λ2 and λ⊥ because of membrane and myelin disruption while simultaneously, and to a lesser extent, decreasing because of immediate axonal swelling. These findings are supported by prior studies of DTI following sciatic nerve transection or traction injuries 22,23 and suggest that high-resolution DTI may be capable of both diagnosis and grading of traumatic peripheral nerve injuries.…”

Section: Discussionsupporting

confidence: 80%

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4.7-T diffusion tensor imaging of acute traumatic peripheral nerve injury

Boyer

Kelm

Riley

et al. 2015

FOC

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Diagnosis and management of peripheral nerve injury is complicated by the inability to assess microstructural features of injured nerve fibers via clinical examination and electrophysiology. Diffusion tensor imaging (DTI) has been shown to accurately detect nerve injury and regeneration in crush models of peripheral nerve injury, but no prior studies have been conducted on nerve transection, a surgical emergency that can lead to permanent weakness or paralysis. Acute sciatic nerve injuries were performed microsurgically to produce multiple grades of nerve transection in rats that were harvested 1 hour after surgery. High-resolution diffusion tensor images from ex vivo sciatic nerves were obtained using diffusion-weighted spin-echo acquisitions at 4.7 T. Fractional anisotropy was significantly reduced at the injury sites of transected rats compared with sham rats. Additionally, minor eigenvalues and radial diffusivity were profoundly elevated at all injury sites and were negatively correlated to the degree of injury. Diffusion tensor tractography showed discontinuities at all injury sites and significantly reduced continuous tract counts. These findings demonstrate that high-resolution DTI is a promising tool for acute diagnosis and grading of traumatic peripheral nerve injuries.

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Section: Discussionsupporting

confidence: 80%

“…2,8 Multiple investigators have evaluated DTI for detecting peripheral nerve crush and traction nerve injuries, which show significant changes in FA following injury. 22,23,25,31 However, limited data exist on high-grade nerve lacerations and there are no prior animal studies of DTI following microsurgical coaptation.…”

mentioning

confidence: 99%

4.7-T diffusion tensor imaging of acute traumatic peripheral nerve injury

Boyer

Kelm

Riley

et al. 2015

FOC

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“…This representation may be useful for surgeons for treatment planning and assessment of the relationship of PN with (Figure 7). In cases of severe PN damage, a decrease of FA values under the determined threshold in the software for its 3D representation, may lead to an underestimation of its structure (40).…”

Section: Peripheral Nerve Traumatic Lesionsmentioning

confidence: 99%

“…However, DWN allows multiplanar reconstructions that facilitate the qualitative assessment of the nerve in almost its entire length, detecting differences in signal intensity of the sciatic nerve in comparison to the contralateral, healthy one ( Figure 13). Furthermore, at the point of nerve compression, ADC shows higher values than in the rest of the nerve, presumably due to the coexistence of edema (40,72). 3D neurographic reconstructions from DTN data may help in the assessment of the relationship between sciatic nerve and piriformis muscle and its several variants that may help clinicians to establish a most certain diagnosis of this underdiagnosed entity (73) (Figure 14).…”

Section: A C Bmentioning

confidence: 99%

Quantitative magnetic resonance (MR) neurography for evaluation of peripheral nerves and plexus injuries

Noguerol¹,

Barousse²,

Socolovsky

et al. 2017

Quant. Imaging Med. Surg.

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Traumatic conditions of peripheral nerves and plexus have been classically evaluated by morphological imaging techniques and electrophysiological tests. New magnetic resonance imaging (MRI) studies based on 3D fat-suppressed techniques are providing high accuracy for peripheral nerve injury evaluation from a qualitative point of view. However, these techniques do not provide quantitative information. Diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) are functional MRI techniques that are able to evaluate and quantify the movement of water molecules within different biological structures. These techniques have been successfully applied in other anatomical areas, especially in the assessment of central nervous system, and now are being imported, with promising results for peripheral nerve and plexus evaluation. DWI and DTI allow performing a qualitative and quantitative peripheral nerve analysis, providing valuable pathophysiological information about functional integrity of these structures.In the field of trauma and peripheral nerve or plexus injury, several derived parameters from DWI and DTI studies such as apparent diffusion coefficient (ADC) or fractional anisotropy (FA) among others, can be used as potential biomarkers of neural damage providing information about fiber organization, axonal flow or myelin integrity. A proper knowledge of physical basis of these techniques and their limitations is important for an optimal interpretation of the imaging findings and derived data. In this paper, a comprehensive review of the potential applications of DWI and DTI neurographic studies is performed with a focus on traumatic conditions, including main nerve entrapment syndromes in both peripheral nerves and brachial or lumbar plexus.

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“…Some peripheral nerve imagers also now routinely use diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI). [7][8][9][10][11][12] The combination of isovolumetric acquisition and diffusion sequences allows for nerve-specific imaging with vascular suppression that may improve the conspicuity of nerve pathology. 1,13,14 The advancement in peripheral nerve MR techniques will likely continue.…”

mentioning

confidence: 99%