In vivo diffusion measurements as an indication of fetal lung maturation using echo planar imaging at 0.5T

Moore, Rachel J.; Strachan, Bryony; Tyler, Damian J.; Baker, Philip N.; Gowland, Penny A.

doi:10.1002/1522-2594(200102)45:2<247::aid-mrm1033>3.0.co;2-m

Cited by 59 publications

(63 citation statements)

References 29 publications

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“…Diffusion-weighted imaging also can be performed to characterize cystic lesions in utero and distinguish them from the bulky mobile amniotic fluid (82). It is also possible that diffusion measurements may be useful assessing lung maturation (83). …”

Section: Diffusion-weighted Imagingmentioning

confidence: 99%

Obstetric MRI

Levine

2006

Magnetic Resonance Imaging

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Ultrasound is the imaging modality of choice for pregnant patients. However, MRI is increasingly utilized in patients in whom the sonographic diagnosis is unclear. These include maternal conditions unique to pregnancy such as ectopic pregnancy, placenta accreta, and uterine dehiscence. MRI is also being increasingly utilized in the assessment of abdominopelvic pain in pregnancy, in particular in assessment for appendicitis. Fetal MRI is performed to assess central nervous system (CNS) abnormalities and patients who are considering fetal surgery for conditions such as neural tube defects, congenital diaphragmatic hernia, and masses that obstruct the airway. In the future, functional MRI and fetal volumetry may provide additional information that can aid in our care of complicated pregnancies.

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Section: Diffusion-weighted Imagingmentioning

confidence: 99%

Obstetric MRI

Levine

2006

Magnetic Resonance Imaging

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“…Therefore, little is known, to date, about the diffusion characteristics of the normal fetal lung. In a previous study, Moore et al [12] were the first to describe the potential value of the ADC as an indicator of fetal lung maturity.…”

Section: Introductionmentioning

confidence: 99%

Diffusion-weighted MR imaging of the normal fetal lung

et al. 2007

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To quantify apparent diffusion coefficient (ADC) changes in fetuses with normal lungs and to determine whether ADC can be used in the assessment of fetal lung development. In 53 pregnancies (20-37th weeks of gestation), we measured ADC on diffusion-weighted imaging (DWI) in the apical, middle, and basal thirds of the right lung. ADCs were correlated with gestational age. Differences between the ADCs were assessed. Fetal lung volumes were measured on T2-weighted sequences and correlated with ADCs and with age. ADCs were 2.13 +/- 0.44 microm(2)/ms (mean +/- SD) in the apex, 1.99 +/- 0.42 microm(2)/ms (mean +/- SD) in the middle third, and 1.91 +/- 0.41 microm(2)/ms (mean +/- SD) in the lung base. Neither the individual ADC values nor average ADC values showed a significant correlation with gestational age or with lung volumes. Average ADCs decreased significantly from the lung apex toward the base. Individual ADCs showed little absolute change and heterogeneity. Lung volumes increased significantly during gestation. We have not been able to identify a pattern of changes in the ADC values that correlate with lung maturation. Furthermore, the individual, gravity-related ADC changes are subject to substantial variability and show nonuniform behavior. ADC can therefore not be used as an indicator of lung maturity.

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“…Many studies have been published regarding fetal MRI of the placenta (2,3). However, studies that address diffusion-weighted imaging (DWI) as an adjunct to routine fetal MRI are limited (3,4).…”

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confidence: 99%

Evaluation of placenta with relative apparent diffusion coefficient and relative T2 signal intensity analysis

Sivrioğlu

Özcan

Türk

et al. 2013

Diagn Interv Radiol

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ORIGINAL ARTICLE PURPOSE We aimed to test the null hypothesis that relative apparent diffusion coefficient (rADC) and relative signal intensity values (rSI HASTE ) do not change in the evaluation of placental maturation with advancing gestational age. MATERIALS AND METHODSFifty-six fetuses with diffusion-weighted magnetic resonance imaging (DW-MRI) data were enrolled in this retrospective study. Fetuses were analyzed in three different gestational age groups: group 1, 18-23 weeks; group 2, 24-28 weeks; and group 3, 29-38 weeks. The rADC (mean ADC/ADC globe ) and rSI HASTE values (mean SI HASTE /SI globe ) were obtained. Two radiologists experienced in fetal MRI who were blinded to the patient information reviewed MRI images independently. Kruskal-Wallis Test was used to compare the rADC and rSI HASTE with gestational age groups. The agreement between the two blinded readers was tested using Krippendorff's alpha ratio. RESULTSBoth placental rADC values and placental rSI HASTE values were not significantly different between the gestational age groups (P = 0.688 and P = 0.280, respectively). rADC and rSI HASTE measurements were reproducible with a good agreement between the two readers (Krippendorff's alpha ratio was 0.613 and 0.778, respectively). CONCLUSIONThe rADC and rSI HASTE values do not change with advancing gestational age.

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In vivo diffusion measurements as an indication of fetal lung maturation using echo planar imaging at 0.5T

Cited by 59 publications

References 29 publications

Obstetric MRI

Obstetric MRI

Diffusion-weighted MR imaging of the normal fetal lung

Evaluation of placenta with relative apparent diffusion coefficient and relative T2 signal intensity analysis

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