volume 192, issue 7, P3080-3090 2014
DOI: 10.4049/jimmunol.1301053
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Nahir Garabatos, Raimon Alvarez, Jorge Carrillo, Jorge Carrascal, Cristina Izquierdo, Harold D. Chapman, Maximiliano Presa, Conchi Mora, David V. Serreze, Joan Verdaguer, Thomas Stratmann

Abstract: Summary Autoreactive B cells are essential for the pathogenesis of type 1 diabetes. The genesis and dynamics of autoreactive B cells remain unknown. Here, we analyzed the immune response in the NOD mouse model to the neuronal protein peripherin (PRPH), a target antigen of islet-infiltrating B cells. PRPH autoreactive B cells recognized a single linear epitope of this protein, in contrast to the multiple epitope recognition commonly observed during autoreactive B cell responses. Autoantibodies to this epitope …

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