In vivo detection of experimentally induced cortical dysgenesis in the adult rat neocortex using optical coherence tomography

Roper, Steven N.; Moores, M.D.; Gelikonov, Grigory V.; Feldchtein, Felix I.; Beach, N.M.; King, Michael A.; Gelikonov, Valentin M.; Sergeev, A.; Reitze, D. H.

doi:10.1016/s0165-0270(97)00202-1

Cited by 44 publications

(34 citation statements)

References 27 publications

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“…However, other studies have shown that the use of 3-T MRI in patients suspected of having a Type 2 FCD improves the detection rate and the lesion characterization because of the transmantle sign being more clearly visible at 3 T. 17 Other novel techniques include the use of optical coherence tomography and the use of high-frequency ultrasonography for micrometer-level intraoperative resolution and the delineation of these lesions. 21 On a more practical level, some centers have used MRI for intraoperative confirmation of complete lesion resection, which may be especially important in patients with lesions located in regions with complex 3D gyral anatomy, such as insular lesions. Once again, the limits of MRI for these lesions will still be manifest here.…”

Section: Volumetrics and Epileptogenesismentioning

confidence: 99%

The influence of lesion volume, perilesion resection volume, and completeness of resection on seizure outcome after resective epilepsy surgery for cortical dysplasia in children

Oluigbo¹,

Wang²,

Whitehead

et al. 2015

PED

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OBJECT Focal cortical dysplasia (FCD) is one of the most common causes of intractable epilepsy leading to surgery in children. The predictors of seizure freedom after surgical management for FCD are still unclear. The objective of this study was to perform a volumetric analysis of factors shown on the preresection and postresection brain MRI scans of patients who had undergone resective epilepsy surgery for cortical dysplasia and to determine the influence of these factors on seizure outcome. METHODS The authors reviewed the medical records and brain images of 43 consecutive patients with focal MRI-documented abnormalities and a pathological diagnosis of FCD who had undergone surgical treatment for refractory epilepsy. Preoperative lesion volume and postoperative resection volume were calculated by manual segmentation using OsiriX PRO software. RESULTS Forty-three patients underwent first-time surgery for resection of an FCD. The age range of these patients at the time of surgery ranged from 2 months to 21.8 years (mean age 7.3 years). The median duration of follow-up was 20 months. The mean age at onset was 31.6 months (range 1 day to 168 months). Complete resection of the area of an FCD, as adjudged from the postoperative brain MR images, was significantly associated with seizure control (p = 0.0005). The odds of having good seizure control among those who underwent complete resection were about 6 times higher than those among the patients who did not undergo complete resection. Seizure control was not significantly associated with lesion volume (p = 0.46) or perilesion resection volume (p = 0.86). CONCLUSIONS The completeness of FCD resection in children is a significant predictor of seizure freedom. Neither lesion volume nor the further resection of perilesional tissue is predictive of seizure freedom.

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Section: Volumetrics and Epileptogenesismentioning

confidence: 99%

The influence of lesion volume, perilesion resection volume, and completeness of resection on seizure outcome after resective epilepsy surgery for cortical dysplasia in children

Oluigbo¹,

Wang²,

Whitehead

et al. 2015

PED

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“…In this regard, the use of optical coherence tomography (OCT) has been proposed, since OCT can improve this structural resolution to about 10 microns. 18 In our study, seizure freedom (Engel Class I) was achieved in over 90% of patients through the duration of follow-up. A literature review of seizure freedom following non-iMRI-guided resection of FCD yielded a range between 46% and 67%.…”

Section: Discussionmentioning

confidence: 49%

Intraoperative MRI–guided resection of focal cortical dysplasia in pediatric patients: technique and outcomes

Sacino¹,

Ho²,

Murnick

et al. 2016

PED

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OBJECTIVE Previous meta-analysis has demonstrated that the most important factor in seizure freedom following surgery for focal cortical dysplasia (FCD) is completeness of resection. However, intraoperative detection of epileptogenic dysplastic cortical tissue remains a challenge, potentially leading to a partial resection and the need for reoperation. The objective of this study was to determine the role of intraoperative MRI (iMRI) in the intraoperative detection and localization of FCD as well as its impact on surgical decision making, completeness of resection, and seizure control outcomes. METHODS The authors retrospectively reviewed the medical records of pediatric patients who underwent iMRI-assisted resection of FCD at the Children's National Health System between January 2014 and April 2015. Data reviewed included demographics, length of surgery, details of iMRI acquisition, postoperative seizure freedom, and complications. Postsurgical seizure outcome was assessed utilizing the Engel Epilepsy Surgery Outcome Scale. RESULTS Twelve consecutive pediatric patients (8 females and 4 males) underwent iMRI-guided resection of FCD lesions. The mean age at the time of surgery was 8.8 years ± 1.6 years (range 0.7 to 18.8 years), and the mean duration of follow up was 3.5 months ± 1.0 month. The mean age at seizure onset was 2.8 years ± 1.0 year (range birth to 9.0 years). Two patients had Type 1 FCD, 5 patients had Type 2A FCD, 2 patients had Type 2B FCD, and 3 patients had FCD of undetermined classification. iMRI findings impacted intraoperative surgical decision making in 5 (42%) of the 12 patients, who then underwent further exploration of the resection cavity. At the time of the last postoperative follow-up, 11 (92%) of the 12 patients were seizure free (Engel Class I). No patients underwent reoperation following iMRI-guided surgery. CONCLUSIONS iMRI-guided resection of FCD in pediatric patients precluded the need for repeat surgery. Furthermore, it resulted in the achievement of complete resection in all the patients, leading to a high rate of postoperative seizure freedom.

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“…The basic lines of development of OCT since it appeared include increasing the vision depth, spatial resolution, and data acquisition rate, methods for determination of velocities of microcapillar flows in biological tissue by measuring the Doppler shift, reception of light scattered by an object in orthogonal polarizations for determining pathological states of biological tissue by both distortions of its birefringence pattern and changes in its depolarization properties [2][3][4][5][6][7], etc.…”

Section: Introductionmentioning

confidence: 99%

“…Our group at the Institute of Applied Physics of the Russian Academy of Sciences created the first portable two-color optical tomograph operated at wavelengths 830 and 1284 nm [3][4][5]7], in which one interferometer is used for simultaneous imaging. Optimization of optical parameters of the low-coherence radiation with the mentioned significantly different wavelengths was performed.…”

Section: Introductionmentioning

confidence: 99%

Two-wavelength optical coherence tomography

Gelikonov

Feldchtein

2004

Radiophys Quantum Electron

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681.787.7We present the results of studies of the basic principles and describe the design of a low-coherence two-wavelength interferometer based on polarization-maintaining fiber. The interferometer was developed for optical coherence tomography (OCT) imaging of the internal structure of living biological tissue simultaneously at two wavelengths, 830 and 1300 nm. Images of several sites of living biological tissue are presented and analyzed.

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In vivo detection of experimentally induced cortical dysgenesis in the adult rat neocortex using optical coherence tomography

Cited by 44 publications

References 27 publications

The influence of lesion volume, perilesion resection volume, and completeness of resection on seizure outcome after resective epilepsy surgery for cortical dysplasia in children

The influence of lesion volume, perilesion resection volume, and completeness of resection on seizure outcome after resective epilepsy surgery for cortical dysplasia in children

Intraoperative MRI–guided resection of focal cortical dysplasia in pediatric patients: technique and outcomes

Two-wavelength optical coherence tomography

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