In Vivo Detection of Calcium from Dicalcium Phosphate Dihydrate Dentifrices in Demineralized Human Enamel and Plaque

Sullivan, Richard; Charig, A.; Blake-Haskins, J.; Zhang, Y.P.; Miller, S; Strannick, M.; Gaffar, Abdul; Margolis, Henry C.

doi:10.1177/08959374970110040201

Cited by 32 publications

(22 citation statements)

References 16 publications

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“…According to the authors, the abrasive particle diameter should be smaller than 10 Ìm so that they could penetrate dental plaque and the CaCO 3 present in the dentifrice used in this study has a particle size ranging from 2.5 to 3.3 Ìm. Furthermore, the deposition of mineral reservoirs in dental plaque has been shown after the use of DCPD-based dentifrice [Sullivan et al, 1997] and chewing gum containing ·-tricalcium-phosphate [Vogel et al, 2000].…”

Section: Discussionmentioning

confidence: 99%

Effect of a Calcium Carbonate-Based Dentifrice on Enamel Demineralization in situ

et al. 2003

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Since the effect of calcium carbonate (CaCO₃) based dentifrice on enamel demineralization is not clearly established, it was evaluated using the IEDT model described by Zero’s group in 1992. This study had a crossover design and 10 volunteers were submitted to 3 treatment groups: a negative control, brushing without dentifrice; an active control, brushing with silica-based dentifrice (SiO₂/MFP group), and the experimental group, brushing with CaCO₃-based dentifrice (CaCO₃/MFP). Both dentifrices contained 1,500 µg F/g (w/w) as sodium monofluorophosphate (MFP). Enamel surface microhardness was determined in the dental blocks and the percentage change in relation to baseline was calculated. Fluoride uptake in enamel and its concentration in ‘test plaque’ were determined. The results showed that the dentifrice containing CaCO₃/MFP was more effective than SiO₂/MFP in reducing enamel demineralization (p < 0.05). A higher concentration of fluoride ion was found in ‘test plaque’ treated with CaCO₃/MFP than in the negative control (p < 0.05). The results suggest that CaCO₃ abrasive may enhance the effect of fluoride present in dentifrice on dental caries control.

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Section: Discussionmentioning

confidence: 99%

Effect of a Calcium Carbonate-Based Dentifrice on Enamel Demineralization in situ

et al. 2003

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“…1, 3) is relevant and it is noteworthly that when the total fluoride content of the NaMFP samples is considered, only the post-rinse NaF 120-min plaque fluid values are statistically greater than the corresponding NaMFP values. Although the second mechanism is usually considered with respect to the calcium and phosphate content of the dentifrice abrasive [Mellberg, 1983;DePaola, 1993;Sullivan et al, 1997], a more important consideration may be the interaction between MFP and the high concentrations of calcium and phosphate present in the oral environment and more particularly where this interaction occurs. Specifically, following a NaMFP rinse, the interaction of these ions with the fluoride ion, which causes the formation of CaF 2 or fluorapatite precipitates, would only occur after MFP hydrolysis within the plaque or in the enamel pores where such mineral phases would be of maximum benefit.…”

Section: Discussionmentioning

confidence: 99%

Fluoride in Plaque Fluid, Plaque, and Saliva Measured for 2 hours after a Sodium Fluoride Monofluorophosphate Rinse

Vogel

Y²,

Chow³

et al. 2000

Caries Res

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Sodium monofluorophosphate (NaMFP) and sodium fluoride (NaF) are the two most common sources of fluoride used in currently marketed fluoride dentifrices. The purpose of this study was to investigate the effect of mouth rinses containing NaF or NaMFP on the concentrations of fluoride, or the MFP ion, in saliva, whole plaque, and plaque fluid. Twelve subjects abstained from tooth brushing for 48 h, fasted overnight, and then rinsed 1 min with 12 mmol/l (228 ppm [μg/g] F) NaF or NaMFP in the morning. Before the rinse and at 30, 60 and 120 min afterwards, upper and lower molar and premolar plaque samples and whole saliva samples were collected. Aliquots of plaque fluid and centrifuged saliva were obtained from these samples, and the whole plaque residue acid extracted. The F and MFP concentrations were then measured in these samples using ultramicro methods. For both rinses, a higher concentration of plaque fluid fluoride was found at lower molar sites while the reverse was true for the whole plaque fluoride. Furthermore, for both rinses, plaque fluid, whole plaque, but not salivary, fluoride concentrations were above baseline at 120 min. Following the NaMFP rinse, a substantial amount of unhydrolyzed MFP was found in plaque fluid and saliva. Although there was a very large range in these measurements, fluoride in plaque fluid (excluding fluoride in unhydrolyzed MFP) and whole plaque were significantly (p<0.05) greater after the NaF rinse at all time periods. In saliva, the NaF rinse produced a statistically significant greater salivary fluoride (excluding fluoride in unhydrolyzed MFP) only at 60 min. The lack of a clear correlation between these measurements and clinical studies suggest a novel mechanism may enhance the effectiveness of NaMFP dentifrices.

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“…It is also used in the Aegis product line, such as Aegis Pit and Fissure Sealant, produced by Bosworth. [18] Sodium calciumphosphosilicate (bioactive glass) When bioactive glass comes in contact with saliva, it rapidly releases sodium, calcium, and phosphorous ions into the saliva that are available for remineralization of the tooth surface. The ions released form hydroxycarbonate apatite (HCA) directly.…”

Section: Reasons To Seek Alternatives To Fluoridesmentioning

confidence: 99%

Latest developments in non-fluoridated remineralizing technologies

Goswami

Saha

Chaitra

2012

J Indian Soc Pedod Prev Dent

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The goal of modern dentistry is to manage non-cavitated carious lesions non-invasively through remineralization in an attempt to prevent disease progression, and to improve strength, esthetics, and function of teeth. The emphasis currently is being given to new technologies for enamel remineralization which suggest the changes in the understanding of dental caries. The aim of this paper is to review the contemporary non-fluoridated systems available for remineralization therapy and ideas for their implementation into clinical practice. A search of articles from "Pubmed" and "Medline" with the keywords Remineralization-demineralization, Casein derivatives, Non-fluoridated remineralizing agents was conducted. A total of 526 abstracts were collected, out of which 172 articles that discussed current technologies of non-fluoridated remineralizing agents were read and 33 most relevant articles were included in this paper. Casein phosphopeptide based technology has been established as a strong non-fluoridated remineralizing agent fulfilling all the criteria of an ideal remineralizing material.

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In Vivo Detection of Calcium from Dicalcium Phosphate Dihydrate Dentifrices in Demineralized Human Enamel and Plaque

Cited by 32 publications

References 16 publications

Effect of a Calcium Carbonate-Based Dentifrice on Enamel Demineralization in situ

Effect of a Calcium Carbonate-Based Dentifrice on Enamel Demineralization in situ

Fluoride in Plaque Fluid, Plaque, and Saliva Measured for 2 hours after a Sodium Fluoride Monofluorophosphate Rinse

Latest developments in non-fluoridated remineralizing technologies

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