In vivo delayed rejection of tumors and inhibition of delayed - type hypersensitivity by HT-29 human colonic adenocarcinoma cell line

Pommier, Gilbert; Garrouste, Françoise; Bettetini, Dominique; Culouscou, Jean-Michel; Remacle‐Bonnet, Maryse

doi:10.1007/bf00205634

Cited by 5 publications

(5 citation statements)

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“…Host responses directed to tumor-associated antigens can include both the development of directed cytotoxic T cells and the development of T cells which mediate DTH reactions important in the resistance to many experimental tumors and métastasés [10,14]. Although there are demonstrable im mune responses at the onset of tumor growth, the progression of most tumors is accompa nied by concomitant immunosuppression [15,16],…”

Section: Discussionmentioning

confidence: 99%

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Immunomodulation by Soluble Factors from Tumor Cells Cultured in vivo in Diffusion Chambers

et al. 1994

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Section: Discussionmentioning

confidence: 99%

“…DTH is important in the resistance to sev eral experimental tumors, since it can be cor related with macrophage activation and mi gration to destroy tumor cells [10]. Tumor cells frequently reside in direct contact with host cells recruited to the tumor site that have been implicated in facilitating tumor angio genesis.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulation by Soluble Factors from Tumor Cells Cultured in vivo in Diffusion Chambers

et al. 1994

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“…A general decline of the immune response concomitant to the growth of various types of tumors in vivo has been reported [1][2][3][4][5][6][7]. How ever, to the best of our knowledge, there has been no study on the possible alteration of the immune responses to exogenous antigens in a T cell lymphoma-bearing animal or human hosts.…”

Section: Introductionmentioning

confidence: 98%

Ascitic Growth of a T Cell Lymphoma in Mice Alters the Humoral and Cellular Immune Response to Exogenous Antigens

Parajuli¹,

Singh²

1997

Tumor Biol

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The effect of the ascitic growth of Dalton’s lymphoma (DL), a T cell lymphoma, on the immune responses of the host mice to exogenous antigens, with respect to the humoral response, delayed-type hypersensitivity (DTH) response and the antigen-presenting ability of macrophages was investigated. The humoral immune response to sheep red blood cells (SRBC) as well as the antigen-presenting ability of macrophages (with keyhole limpet hemocyanin as the standard antigen) in the DL-bearing mice were consistently higher than in the normal mice, although the magnitude showed a decline during later tumor stages. However, the DTH response to SRBC was suppressed in the DL-bearing mice compared with the response in the normal mice. The possible mechanisms are discussed. In vivo administration of FK565, a synthetic biological response modifier, enhanced the humoral immune response as well as the antigen-presenting ability of the macrophages in the normal and early DL-bearing mice, whereas these immune responses n the later tumor-bearing animals were found to be nonresponsive to FK565 treatment. In contrast, the DTH response in the normal as well as in the DL-bearing mice was suppressed on FK565 administration. This is the first study of its kind regarding the effect of the ascitic growth of any T cell lymphoma on various aspects of the immune response to exogenous antigens and the correlation thereof with an immuno-modulator.

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“…However, the molecular weight of this factor was only of the order of 10-12kD but was distinct from P15E. Pommier et al (1987) and Ebert et al (1987) have described a factor present in conditioned medium from HT-29 cells which was able to inhibit IL-2 production and lymphocyte proliferation and whose effects could not be prevented by the addition of further IL-2. The molecular weight of their factor was around 56 kD and because our factor(s) also appear to inhibit lymphocyte proliferation at higher concentrations the two may be identical.…”

mentioning

confidence: 97%

“…A number of reports have demonstrated that supernatants derived from tumour cell lines can inhibit lymphocyte proliferation and cytokine production (Werkmeister et al, 1980;Meischner et al, 1986;Ebert et al, 1987;Pommier et al, 1987;Farram et al, 1982;Hersey et al, 1983). However, the effects of these supernatants on the generation of cytotoxic responses has rarely been examined (Cozzolino et al, 1987 33258.…”

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confidence: 99%

Suppression of the generation of lymphokine-activated killer (LAK) cells by serum-free supernatants of in vitro maintained tumour cell lines

Guillou

Ramsden²,

Somers³

et al. 1989

Br J Cancer

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Summary Serum-free supernatants from in vitro maintained gastrointestinal cancer and melanoma cell lines inhibit the generation of lymphokine (IL-2) activated killer (LAK) Lafreniere et al., 1985;Mule et al., 1986b;Rosenberg et al., 1986). Unfortunately this experience is not paralleled by the clinical application of such an approach where some 60% of patients with metastatic disease fail to respond to this therapy West et al., 1987;Topalian et al., 1988). Similarly, treatment with IL-2 alone appears to be ineffective (Lotze et al., 1986) despite the fact that many human tumours are infiltrated by host mononuclear cells which might become cytotoxic following exposure to IL-2 in vivo (Svennevig et al., 1984;Cozzolino et al., 1986).Prompted by the observations that both IL-2 production and LAK cell generation were impaired with patients with tumours which had extended beyond local confines (Monson et al., 1986(Monson et al., , 1987, we have previously shown that the presence of low numbers of some cell-line derived tumour cells was found to potently inhibit LAK cell generation in vitro (Guillou et al., 1989). A number of reports have demonstrated that supernatants derived from tumour cell lines can inhibit lymphocyte proliferation and cytokine production (Werkmeister et al., 1980; Meischner et al., 1986;Ebert et al., 1987;Pommier et al., 1987;Farram et al., 1982;Hersey et al., 1983). However, the effects of these supernatants on the generation of cytotoxic responses has rarely been examined (Cozzolino et al., 1987

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In vivo delayed rejection of tumors and inhibition of delayed - type hypersensitivity by HT-29 human colonic adenocarcinoma cell line

Cited by 5 publications

References 33 publications

Immunomodulation by Soluble Factors from Tumor Cells Cultured in vivo in Diffusion Chambers

Immunomodulation by Soluble Factors from Tumor Cells Cultured in vivo in Diffusion Chambers

Ascitic Growth of a T Cell Lymphoma in Mice Alters the Humoral and Cellular Immune Response to Exogenous Antigens

Suppression of the generation of lymphokine-activated killer (LAK) cells by serum-free supernatants of in vitro maintained tumour cell lines

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