In Vivo Degradation of Cholesterol to Bile Acids Is Reduced in Patients Receiving Parenteral Nutrition

Abstract

In vivo 7α-hydroxylation is suppressed in artificial nutrition, particularly in PN. The finding associates with reduced cholesterol production, possibly as a metabolic consequence. The data suggest a regulatory role of gastrointestinal hormones and FGF19 on bile acid production and might suggest a pathophysiological basis for some common complications of artificial nutrition, such as gallstone disease and cholestasis.

Modifying Serum Plant Sterol Concentrations: Effects on Markers for Whole Body Cholesterol Metabolism in Children Receiving Parenteral Nutrition and Intravenous Lipids

“…The strength of our study is that in contrast to the earlier studies by Kurvinen, our subjects served as their own controls, allowing us to compare changes at different time points. However, the reported changes in cholesterol synthesis in conditions where plant sterol concentrations are increased are not consistent, since others have reported unchanged [17] or even decreased synthesis [18] in these conditions. These discrepancies may be caused by differences in patient populations, i.e., comparisons of SBS patients with PN vs. SBS patients without PN, or versus healthy controls.…”

Different cardiovascular risk scores in adults receiving long-term home parenteral nutrition

“…The production of cholesterol is impaired in this group. In particular, the serum lathosterol-to-cholesterol ratio is significantly reduced, resulting in reduced cholesterol production [10].…”