In vivo degradation behaviour and bone response of a new Mg-rare earth alloy immobilized in a rat femoral model

Wang, Haijian; Kobayashi, Takashi; Zhang, Ying; Wang, Haiwei; Ju, Dongying

doi:10.1016/j.mtcomm.2020.101727

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…The addition of rare earth metal elements promotes the dynamic recrystallization of Mg alloys and increases tensile strength without loss of elongation. Wang et al [ 36 ] found that both Mg-10La and Mg-20Ce alloys prepared by vertical twin roll casting (TRC) technology had better corrosion resistance than AZ31 alloy. Observation of FE-SEM images showed that the microstructure of AZ31 alloy was composed of inhomogeneous dendrites, whereas that of Mg-RE alloy was amorphous.…”

Section: Research On High Performance Biodegradable Mg Alloysmentioning

confidence: 99%

“…It was found (as shown Figure 1 ) that the corrosion pit of sample 325-30 was the largest, and the corrosion pit of sample 450-3 was slightly smaller than that of sample 350-5, indicating that its corrosion resistance was the best. Table 1 shows the mechanical properties and corrosion resistances of some typical Mg-RE alloys [ 32 , 33 , 34 , 35 , 36 ]. Most Mg-RE alloys have excellent mechanical properties and corrosion resistances; however, when rare earth metal elements are selected, focus should be on the cytotoxicity of the elements and their impact on the function of the human body.…”

Section: Research On High Performance Biodegradable Mg Alloysmentioning

confidence: 99%

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Systems, Properties, Surface Modification and Applications of Biodegradable Magnesium-Based Alloys: A Review

Chen

Kolawole

et al. 2022

Materials

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In recent years, biodegradable magnesium (Mg) alloys have attracted the attention of many researchers due to their mechanical properties, excellent biocompatibility and unique biodegradability. Many Mg alloy implants have been successfully applied in clinical medicine, and they are considered to be promising biological materials. In this article, we review the latest research progress in biodegradable Mg alloys, including research on high-performance Mg alloys, bioactive coatings and actual or potential clinical applications of Mg alloys. Finally, we review the research and development direction of biodegradable Mg alloys. This article has a guiding significance for future development and application of high-performance biodegradable Mg alloys, promoting the future advancement of the magnesium alloy research field, especially in biomedicine.

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Section: Research On High Performance Biodegradable Mg Alloysmentioning

confidence: 99%

Section: Research On High Performance Biodegradable Mg Alloysmentioning

confidence: 99%

Systems, Properties, Surface Modification and Applications of Biodegradable Magnesium-Based Alloys: A Review

Chen

Kolawole

et al. 2022

Materials

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“…To date, the pre-clinical application of Mg-based implants primarily includes bone screws, plates, and screw systems [ 17 , 18 , 19 ]; however, Mg and its alloys generate hydrogen gas at the early implantation stage, forming gas cavities [ 10 ]. Numerous studies have focused on improving alloying [ 20 , 21 ], coating [ 22 , 23 ], and surface modification techniques [ 24 ] to regulate degradation rate and the related biological response.…”

Section: Introductionmentioning

confidence: 99%

Influence of Surface Roughness on Biodegradability and Cytocompatibility of High-Purity Magnesium

Dai

Qian

Li³

et al. 2022

Materials

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High-purity magnesium (Mg) is a promising biodegradable metal for oral and maxillofacial implants. Appropriate surface roughness plays a critical role in the degradation behavior and the related cellular processes of biodegradable Mg-based metals. Nevertheless, the most optimized surface roughness has been questionable, especially for Mg-based oral and maxillofacial implants. Three representative scales of surface roughness were investigated in this study, including smooth (Sa < 0.5 µm), moderately rough (Sa between 1.0–2.0 µm), and rough (Sa > 2.0 µm). The results indicated that the degradation rate of the Mg specimen in the cell culture medium was significantly accelerated with increased surface roughness. Furthermore, an extract test revealed that Mg with different roughness did not induce an evident cytotoxic effect. Nonetheless, the smooth Mg surface had an adversely affected cell attachment. Therefore, the high-purity Mg with a moderately rough surface exhibited the most optimized balance between biodegradability and overall cytocompatibility.

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In vivo degradation and bone reaction of long-term fixation with a magnesium alloy made by twin-roll casting in a rat femur model

Zhang

Wang

Kobayashi

et al. 2023

BME

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BACKGROUND: The effect of casting parameters on the microstructure and corrosion resistance of Mg alloys is still limited, especially in clinical animal experiments. OBJECTIVE: We prepared a new magnesium rare earth alloy (Mg-Re, where Re is Ce or La) by vertical two-roll casting and Mg-A by further rolling. The microstructure characteristics, degradation behavior, and bone reaction of the two alloys were studied. METHOD: Ti, Mg-Re, and Mg-A alloy plates were implanted in a rat femur model, and their degradation behavior was observed 48 weeks later. RESULTS: In vivo experiments showed no significant changes around the femur in the Ti group, excluding external factors that may cause bone remodeling and lead to new bone formation. Mg-A induces more new bone formation than Mg-Re, which meets the necessary conditions to prevent pathological fracture. The specimen staining and sectioning showed that the liver and heart of rats implanted with magnesium alloys had no pathological changes and the cell structure was normal, similar to that of rats without a magnesium alloy. CONCLUSION: Mg-A alloy has good healing potential as a biodegradable implant material.

show abstract

In vivo degradation behaviour and bone response of a new Mg-rare earth alloy immobilized in a rat femoral model

Cited by 5 publications

References 42 publications

Systems, Properties, Surface Modification and Applications of Biodegradable Magnesium-Based Alloys: A Review

Systems, Properties, Surface Modification and Applications of Biodegradable Magnesium-Based Alloys: A Review

Influence of Surface Roughness on Biodegradability and Cytocompatibility of High-Purity Magnesium

In vivo degradation and bone reaction of long-term fixation with a magnesium alloy made by twin-roll casting in a rat femur model

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