In-vivo dark-field and phase-contrast x-ray imaging

Bech, Martin; Tapfer, Arne; Velroyen, Astrid; Yaroshenko, Andre; Pauwels, B.; Hostens, Jeroen; Bruyndonckx, Peter; Sasov, Alexander; Pfeiffer, Franz

doi:10.1038/srep03209

Cited by 146 publications

(120 citation statements)

References 18 publications

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“…These two techniques work with conventional x-ray sources and can be adapted to existing medical imaging systems [6]. Several groups have shown promising results for medical imaging applications [7][8][9][10][11] as well as for non-destructive testing [12][13][14][15][16]. For quality assessment of a Talbot-Lau interferometer, the visibility is a crucial quantity.…”

Section: Introductionmentioning

confidence: 99%

Designing the phase grating for Talbot-Lau phase-contrast imaging systems: a simulation and experiment study

et al. 2016

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Abstract:The performance of a Talbot-Lau interferometer depends to a great extent on its visibility. This means, to obtain high quality phase-contrast and dark-field images a high visibility is mandatory. Several parameters influence the visibility of such a system, like for example the x-ray spectrum, the inter-grating distances or the parameters of the three gratings. In this multidimensional space, wave field simulations help to find the optimal combination of the grating specifications to construct a setup with a high visibility while retaining a fixed angular sensitivity. In this work we specifically analyzed the influence of the G1 grating duty cycle in simulations and experiments. We show that there is a lot of room for improvement by varying the duty cycle of the phase-shifting grating G1. As a result, by employing a third-integer duty cycle we can increase the visibility to up to 53 % in a laboratory setup with a polychromatic spectrum. The achieved visibility is more than two times higher compared to the result with a standard-type setup. This visibility gain allows a dose reduction by a factor of 5 preserving the same image quality. "Energy-resolved visibility analysis of grating interferometers operated at polychromatic X-ray sources," Opt.

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Section: Introductionmentioning

confidence: 99%

Designing the phase grating for Talbot-Lau phase-contrast imaging systems: a simulation and experiment study

et al. 2016

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“…In x-ray, a similar phase derivative result is obtained by grating interferometers, 17 which can be considered a parallelized splitdetector DPC measurement on the imaging (rather than illumination) side. Darkfield can also be extracted, 18 and the derivative images can be integrated in order to recover the quantitative phase. 12,19 The ability to separate the phase from absorption information should be considered a significant advantage of DPC over phase contrast methods such as Zernike phase contrast, DIC, Hoffman modulation contrast, 20 and Dodt contrast.…”

Section: Multicontrast Imaging With An Led Array Sourcementioning

confidence: 99%

Real-time brightfield, darkfield, and phase contrast imaging in a light-emitting diode array microscope

et al. 2014

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Abstract. We demonstrate a single-camera imaging system that can simultaneously acquire brightfield, darkfield, and phase contrast images in real time. Our method uses computational illumination via a programmable light-emitting diode (LED) array at the source plane, providing flexible patterning of illumination angles. Brightfield, darkfield, and differential phase contrast images are obtained by changing the LED patterns, without any moving parts. Previous work with LED array illumination was only valid for static samples because the hardware speed was not fast enough to meet real-time acquisition and processing requirements. Here, we time multiplex patterns for each of the three contrast modes in order to image dynamic biological processes in all three contrast modes simultaneously. We demonstrate multicontrast operation at the maximum frame rate of our camera (50 Hz with 2160 × 2560 pixels).

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“…With an incremental modification to the conventional X-ray imaging apparatuses, this technology is able to yield three different physical contrasts of the underlying sample in one scan: the conventional absorption contrast, differential phase contrast (DPC) and small-angle scattering contrast, resulting in much richer information than the traditional absorption-based imaging approaches [1][2][3][4]. Successful experiments have been demonstrated for mammography [5], hand imaging [6,7] and lung imaging [8,9] using a X-ray tube-based configuration.…”

Section: Introductionmentioning

confidence: 99%

Spline based iterative phase retrieval algorithm for X-ray differential phase contrast radiography

Nilchian¹,

Wang²,

Thuering³

et al. 2015

Opt. Express

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Differential phase contrast imaging using grating interferometer is a promising alternative to conventional X-ray radiographic methods. It provides the absorption, differential phase and scattering information of the underlying sample simultaneously. Phase retrieval from the differential phase signal is an essential problem for quantitative analysis in medical imaging. In this paper, we formalize the phase retrieval as a regularized inverse problem, and propose a novel discretization scheme for the derivative operator based on B-spline calculus. The inverse problem is then solved by a constrained regularized weighted-norm algorithm (CRWN) which adopts the properties of B-spline and ensures a fast implementation. The method is evaluated with a tomographic dataset and differential phase contrast mammography data. We demonstrate that the proposed method is able to produce phase image with enhanced and higher soft tissue contrast compared to conventional absorption-based approach, which can potentially provide useful information to mammographic investigations.

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In-vivo dark-field and phase-contrast x-ray imaging

Cited by 146 publications

References 18 publications

Designing the phase grating for Talbot-Lau phase-contrast imaging systems: a simulation and experiment study

Designing the phase grating for Talbot-Lau phase-contrast imaging systems: a simulation and experiment study

Real-time brightfield, darkfield, and phase contrast imaging in a light-emitting diode array microscope

Spline based iterative phase retrieval algorithm for X-ray differential phase contrast radiography

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