In vivo corrosion and corrosion protection of magnesium alloy LAE442☆

Witte, Frank; Fischer, J.; Nellesen, J.; Vogt, Carsten; Vogt, Juergen; Donath, Tilman; Beckmann, Felix

doi:10.1016/j.actbio.2009.10.012

Cited by 397 publications

(236 citation statements)

References 23 publications

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“…For instance, Mg-Calcium alloys are biocompatible but degrade quite rapidly [21,22]. Mg-Fluoride coating has been reported to reduce the in vivo degradation rate of Mg implants and rare earth metals that are frequently used 4 as alloy materials for Mg can cause cytotoxic effects [23,24]. Recently, members of our consortium reported a novel Mg alloy containing 2% silver (Mg2Ag), which was cast and treated by a solidification cooling process, resulting in appropriate mechanical properties and a rather low degradation rate.…”

Section: Introductionmentioning

confidence: 99%

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Jähn¹,

Saito

Taipaleenmäki

et al. 2016

Acta Biomaterialia

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Intramedullary stabilization is frequently used to treat long bone fractures. Implants usually remain unless complications arise. Since implant removal can become technically very challenging with the potential to cause further tissue damage, biodegradable materials are emerging as alternative options. Magnesium (Mg)-based biodegradable implants have a controllable degradation rate and good tissue compatibility, which makes them attractive for musculoskeletal research. Here we report for the first time the implantation of intramedullary nails made of an Mg alloy containing 2% silver (Mg2Ag) into intact and fractured femora of mice. Prior in vitro analyses revealed an inhibitory effect of Mg2Ag degradation products on osteoclast differentiation and function with no impair of osteoblast function. In vivo, Mg2Ag implants degraded under non-fracture and fracture conditions within 210 days and 133 days, respectively. During fracture repair, osteoblast function and subsequent bone formation were enhanced, while osteoclast activity and bone resorption were decreased, leading to an augmented callus formation. We observed a widening of the femoral shaft under steady state and regenerating conditions, which was at least in part due to an uncoupled bone remodeling. However, Mg2Ag implants did not cause any systemic adverse effects. These data suggest that Mg2Ag implants might be promising for intramedullary fixation of long bone fractures, a novel concept that has to be further investigated in future studies.

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Section: Introductionmentioning

confidence: 99%

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Jähn¹,

Saito

Taipaleenmäki

et al. 2016

Acta Biomaterialia

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“…The results of skin sensitizing potential show that the LAE442 alloy exhibits anaphylactic reactions similar to the Ti6Al4V alloy [18]. The in vivo results of the LAE442 alloy and MgF 2 -coated LAE442 [19] show that no adverse host reactions and infections have been clinically observed during the postoperative follow up. All results of the blood examination for cereal third transaminase, aspartate transaminase, alkaline phosphatase, creatinine, total protein as well as four cell counts (erythrocytes, leucocytes, hematocrit, hemoglobin) are in the physiological range for the rabbits.…”

Section: Introductionmentioning

confidence: 68%

In vitro degradation and biocompatibility of Mg-Li-Ca alloys—the influence of Li content

et al. 2017

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“…Under this condition, the metal surface could not be covered entirely by the anodic film. The film formation under a PBR greater than unity and the development of MgF 2 -based films, which have been reported to improve the corrosion resistance of magnesium alloys [24], may be responsible for the growth of the present anodic films on magnesium at high current efficiency.…”

Section: Methodsmentioning

confidence: 99%

Efficient growth of anodic films on magnesium in organic electrolytes containing fluoride and water

Habazaki

Kataoka

Tsuji

et al. 2014

Electrochemistry Communications

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The present study reports, for the first time, the highly efficient formation of barrier-type anodic films, with flat and parallel metal/film and film/electrolyte interfaces, on magnesium in ethylene glycol electrolytes containing ammonium fluoride and water. The anodizing voltage increases linearly with time during galvanostatic anodizing at 10 A m -2 up to 350 V.The anodic film formed to 200 V is 247 nm thick, containing a crystalline MgF 2 phase.Analysis by Rutherford backscattering spectroscopy discloses the film composition of MgF 1.8 O 0.1 and Pilling-Bedworth ratio (PBR) of 1.67. The PBR value greater than unity and the formation of chemically stable fluoride-based films may contribute to the film growth at high current efficiency.

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In vivo corrosion and corrosion protection of magnesium alloy LAE442☆

Cited by 397 publications

References 23 publications

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

In vitro degradation and biocompatibility of Mg-Li-Ca alloys—the influence of Li content

Efficient growth of anodic films on magnesium in organic electrolytes containing fluoride and water

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