In vivo continuous and simultaneous monitoring of brain energy substrates with a multiplex amperometric enzyme-based biosensor device

Cordeiro, Carlos De Lima Braga Lopes; Vries, Martin G. de; Ngabi, W; Oomen, Pieter E.; Cremers, Thomas; Westerink, Ben H.C.

doi:10.1016/j.bios.2014.09.101

Cited by 39 publications

(41 citation statements)

References 83 publications

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“…Our results obtained with the multi-electrode micro-probes in this study are in agreement with this previously reported data. We should note, however, that a recent study by Cordeiro et al (2015) showed a decrease in lactate levels in response to both insulin and glucose injections. The causes of this apparent discrepancy are still unclear, and could be related to the different geometry of the biosensor systems, and the number of brain penetrations in the two studies.…”

Section: Validation Of Multi-sensing Probe In the Brain Of The Anesthmentioning

confidence: 88%

“…By comparison, different types of enzyme biosensors provided more widespread glucose concentration estimates: 500 mM, (Calia et al, 2009); 1.3 mM (Cordeiro et al, 2015); 2.6 mM (Hu and Wilson, 2002). Lactate basal extracellular concentration was also widespread, with quantifications up to 1.6 mM (Cordeiro et al, 2015). The reasons for such discrepancies between biosensor studies are still unclear.…”

Section: Validation Of Multi-sensing Probe In the Brain Of The Anesthmentioning

confidence: 91%

“…It has been implemented to quantify glucose and lactate basal levels between 1 and 1.5 mM (Krebs-Kraft et al, 2009;Rex et al, 2009) and 346 mM (Demestre et al, 1997) respectively, which were very close to our estimates. By comparison, different types of enzyme biosensors provided more widespread glucose concentration estimates: 500 mM, (Calia et al, 2009); 1.3 mM (Cordeiro et al, 2015); 2.6 mM (Hu and Wilson, 2002). Lactate basal extracellular concentration was also widespread, with quantifications up to 1.6 mM (Cordeiro et al, 2015).…”

Section: Validation Of Multi-sensing Probe In the Brain Of The Anesthmentioning

confidence: 95%

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Section: Validation Of Multi-sensing Probe In the Brain Of The Anesthmentioning

confidence: 88%

Section: Validation Of Multi-sensing Probe In the Brain Of The Anesthmentioning

confidence: 91%

Section: Validation Of Multi-sensing Probe In the Brain Of The Anesthmentioning

confidence: 95%

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Silicon/SU8 multi-electrode micro-needle for in vivo neurochemical monitoring

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“…Cordeiro et al . have recently published their work on the development and characterization of an implantable multiplex microbiosensor for the simultaneous and continuous in vivo monitoring of glucose, lactate, and pyruvate.…”

Section: Disease Biomarker Detection At Structurally Small Electrodesmentioning

confidence: 99%

Recent Advances in Biosensing for Neurotransmitters and Disease Biomarkers using Microelectrodes

2017

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This Minireview focuses on recent advances in the applications of microelectrodes to detect and monitor targeted analytes in bioelectrochemical processes. Notably, these processes are electrochemically driven reactions that involve the detection of targets from the biological realm. Wide‐ranging applications of electrochemical sensors have been reported in the last few decades in various research fields, owing to favorable attributes such as high selectivity and sensitivity, rapid analysis, simplicity, easy fabrication, and cost effectiveness. Accordingly, in this Minireview, we explore recent advances in bioelectrochemistry based on small detection probes or structures modified for a variety of analytes, exploiting multi‐approach advantages of enhanced electrochemical detection surface or targeted analyte pursuit. The target analytes included in this Minireview are neurotransmitters and disease biomarkers detected using enzymatic and non‐enzymatic electrode modifications.

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“…The techniques allow for the development of smaller electrodes that provide improved spatial and temporal resolution as well as multiple sensing electrodes with precisely defined geometries. Micro-electrochemical sensors allow the continuous, precise and fast in situ measurement of metabolic parameters directly within the tissue (Cordeiro et al, 2015;Hinzman et al, 2015aHinzman et al, , 2015bKealy et al, 2013;Rocchitta et al, 2013;Wei et al, 2014;Weltin et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Single probe for real-time simultaneous monitoring of neurochemistry and direct-current electrocorticography

Limnuson

et al. 2016

Biosensors and Bioelectronics

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We report a novel single neural probe for real-time simultaneous monitoring of multiple neurochemicals and direct-current electrocorticography (DC-ECoG). A major advance of this probe is the inclusion of two iridium oxide reference electrodes to improve sensor accuracy. The ECoG reference electrode is identical to the ECoG recording electrodes to significantly improve DC stability, while the reference for electrochemical sensors has 10-fold lower polarization rate to minimize the small current-induced drift in the reference electrode potential. In vitro, the single probe selectively measured oxygen (r(2)=0.985 ± 0.01, concentration range=0-60 mmHg, limit of detection=0.4 ± 0.07 mmHg) and glucose (r(2)=0.989 ± 0.009, concentration range=0-4mM, limit of detection=31 ± 8 µM) in a linear fashion. The performance of the single probe was assessed in an in vivo needle prick model to mimic sequelae of traumatic brain injury. It successfully monitored the theoretically expected transient brain oxygen, glucose, and DC potential changes during the passage of spreading depolarization (SD) waves. We envision that the developed probe can be used to decipher the cause-effect relationships between multiple variables of brain pathophysiology with the high temporal and spatial resolutions that it provides.

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In vivo continuous and simultaneous monitoring of brain energy substrates with a multiplex amperometric enzyme-based biosensor device

Cited by 39 publications

References 83 publications

Silicon/SU8 multi-electrode micro-needle for in vivo neurochemical monitoring

Silicon/SU8 multi-electrode micro-needle for in vivo neurochemical monitoring

Recent Advances in Biosensing for Neurotransmitters and Disease Biomarkers using Microelectrodes

Single probe for real-time simultaneous monitoring of neurochemistry and direct-current electrocorticography

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