In Vivo Confocal Microscopy of Meibomian Glands in Contact Lens Wearers

Villani, Edoardo; Ceresara, Gaia; Beretta, Silvia; Magnani, Fabrizio; Viola, Francesco; Ratiglia, Roberto

doi:10.1167/iovs.11-7427

Cited by 92 publications

(134 citation statements)

References 23 publications

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“…Although most of the results from the present study agree with past studies on this topic, 13,35Y38 there were some disagreements. 13,35,36 For example, Villani et al's study 13 found TBUT and gland expressibility to be different between the two groups whereas the present study did not find a difference. Differences in results may have arisen because Villani et al 13 recruited symptomatic subjects whereas the present study mostly had normal subjects.…”

Section: Meibomian Gland Atrophy In Daily Contact Lens Wearersvpuckercontrasting

confidence: 70%

“…13,35,36 For example, Villani et al's study 13 found TBUT and gland expressibility to be different between the two groups whereas the present study did not find a difference. Differences in results may have arisen because Villani et al 13 recruited symptomatic subjects whereas the present study mostly had normal subjects. An additional discrepancy was with Guillon and Maissa's work, 35 which determined that there was no significant difference in lissamine green staining between the two groups, and they found that the CL group was significantly more likely to have symptoms than the NCL group.…”

Section: Meibomian Gland Atrophy In Daily Contact Lens Wearersvpuckercontrasting

confidence: 70%

“…5Y7 Although this procedure has been used by a number of investigators to analyze meibomian gland atrophy in the general population, these studies have typically excluded CL wearers. 8Y12 Although there have been attempts to analyze this subgroup, 6,13,14 these studies either have failed to fully address how meibomian gland atrophy is related to ocular signs and symptoms in CL wearers (e.g., lack of symptoms data) 6,14 or have included too few subjects to provide generalizable results. 13 To date, there has yet to be a study aimed at fully describing how meibomian gland atrophy is associated with ocular signs and symptoms in CL wearers.…”

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confidence: 99%

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Associations with Meibomian Gland Atrophy in Daily Contact Lens Wearers

2016

Optometry and Vision Science

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Purpose. To determine associations for contact lenses (CLs) and meibomian gland atrophy in a matched-pair study. Methods. Contact lens wearers (case) and age-and sex-matched nonYcontact lens (NCL) wearers with no history of CL use (control) were recruited for a multicenter study. All subjects were administered the Ocular Surface Disease Index questionnaire and a comprehensive battery of clinical tests (e.g., tear breakup time, bulbar and limbal redness, meibography, etc.) were performed. Upper and lower eyelid meibomian gland atrophy were graded with both digital meibography (percent gland atrophy) and visual meiboscore methods. Conditional logistic regression analyses were then used to determine relationships among CL use, meibomian gland atrophy, and ocular surface signs and symptoms. Results. A total of 70 matched pairs were analyzed. The mean (TSD) age of the CL group was 30.6 (T12.4) years, and that of the NCL group was 30.1 (T12.2) years. The subjects were 63% female. The association between CL wear and meiboscore was not significant univariately, but the best-fitting multivariate regression model showed that higher meiboscores were associated with being a CL wearer (odds ratio [OR], 2.45) in a model that included eyelid margin erythema (OR, 0.25) and lissamine green staining (OR, 1.25). Percent gland atrophy was not associated with CL wear in regression analysis (p = 0.31).Conclusions. This study determined inconclusive associations with CLs and meibomian gland atrophy. This study also provided a comprehensive assessment of differences between CL and NCL wearers. (Optom Vis Sci 2015;92:e206Ye213)

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Section: Meibomian Gland Atrophy In Daily Contact Lens Wearersvpuckercontrasting

confidence: 70%

Section: Meibomian Gland Atrophy In Daily Contact Lens Wearersvpuckercontrasting

confidence: 70%

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confidence: 99%

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Associations with Meibomian Gland Atrophy in Daily Contact Lens Wearers

2016

Optometry and Vision Science

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“…116 This LSCM study of meibomian glands showed significantly decreased basal epithelial cell density, lower acinar unit diameters, higher glandular orifice diameters, and greater inhomogeneity of the periglandular interstices in CL wearers compared with that in controls. These authors interpret such morphologic changes as signs of MGDo, duct obstruction, and glandular inflammation.…”

Section: Meibomian Gland Dropoutmentioning

confidence: 59%

Mechanical Complications Induced by Silicone Hydrogel Contact Lenses

Lin

Yeh

2013

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…Meibomian gland morphology can be evaluated by imaging methods such as infrared meibography [24 •• , 25-28, 29 •• ], optical coherence tomography (OCT) meibography [30, 31 • , 32], and in vivo confocal microscopy (IVCM) [33][34][35][36][37]. Meibography was first described in 1977 when Tapie described a basic method of eyelid transillumination, using a diaphanoscope with a red light filter to retroilluminate the meibomian gland silhouette that was observed with a slit-lamp microscope [38].…”

Section: Introductionmentioning

confidence: 99%

Objective Metrics of Ocular Surface Disease in Contact Lens Wearers: Meibography

Qazi

Hamrah

2015

Curr Ophthalmol Rep

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Dry eye symptoms are very prevalent in contact lens wearers and are most commonly attributed to evaporative dry eye (EDE) due to alterations in the quality of the pre-lens tear film lipids. Meibomian gland dysfunction (MGD), the most common cause of EDE, may result in contact lens-associated dry eye and ultimately to intolerance to contact lens wear. Thus, a thorough assessment of meibomian glands and the eyelid margin prior to and during contact lens wear may ensure continuous contact lens tolerance and the maintenance of a healthy ocular surface. Since meibomian glands are not overtly visible on slit-lamp biomicroscopy, imaging methods such as infrared meibography could play an important role in the evaluation of meibomian gland health. This review discusses the most pertinent advances in infrared meibography and its application to contact lens wearers, with a focus on the utility of quantitative imaging methods in the evaluation of meibomian glands.

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In Vivo Confocal Microscopy of Meibomian Glands in Contact Lens Wearers

Cited by 92 publications

References 23 publications

Associations with Meibomian Gland Atrophy in Daily Contact Lens Wearers

Associations with Meibomian Gland Atrophy in Daily Contact Lens Wearers

Mechanical Complications Induced by Silicone Hydrogel Contact Lenses

Objective Metrics of Ocular Surface Disease in Contact Lens Wearers: Meibography

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