In Vivo Confocal Microscopy in Primary Congenital Glaucoma With Megalocornea

Mastropasqua, L.; Carpineto, Paolo; Ciancaglini, Marco; Nubile, Mario; Doronzo, Emanuele

doi:10.1097/00061198-200204000-00002

Cited by 46 publications

(32 citation statements)

References 19 publications

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“…11,21 In accord with earlier studies 7,8 we found abnormalities in the Descemet's membrane and the endothelium in buphthalmic eyes. The density of endothelial cells was significantly lower in buphthalmic eyes, and the mean area of these cells was significantly larger compared with healthy eyes.…”

Section: Discussionsupporting

confidence: 91%

“…However, we did not prove increased polymegathism and pleomorphism of the endothelial cells in buphthalmic eyes compared with the healthy eyes. The mean endothelial cell area in the buphthalmic eyes was smaller than that in the cases by Mastropasqua et al 8 Morphologic changes in the buphthalmic corneas were also clearly visible as Haab's striae on the Descemet's membranes. Very hyperreflective acellular scar tissue was also often observed at this tissue level.…”

Section: Discussioncontrasting

confidence: 54%

“…1,2 Only a few studies [7][8][9] have analyzed the histopathological findings in buphthalmic corneas. Mastropasqua et al 8 described findings from two adult patients with congenital glaucoma with buphthalmos using an in vivo confocal microscope. Using this modern technology, we studied the corneal changes in a group of patients with unilateral buphthalmos.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies [7][8][9][10] have been published that describe changes in buphthalmic eyes and histologic changes in the particular corneal layers in patients with buphthalmos. Corneal confocal microscopy allows study of the human cornea in vivo at the microscopic level.…”

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confidence: 99%

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Corneal Changes Assessed Using Confocal Microscopy in Patients With Unilateral Buphthalmos

Mahelková

Filouš

Odehnal

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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Citation: Mahelková G, Filouš A, Odehnal M, Cendelín J. Corneal changes assessed using confocal microscopy in patients with unilateral buphthalmos. Invest Ophthalmol Vis Sci. 2013;54:4048-4053. DOI:10. 1167/iovs.12-11165 PURPOSE. To compare corneal structures in buphthalmic eyes and healthy eyes in patients with unilateral congenital glaucoma using a corneal confocal microscope.METHODS. Ten patients with unilateral buphthalmos (mean 6 SD age, 14.85 6 5.12 years) were examined using corneal confocal microscopy. The cell density and cell area of endothelial cells and superficial and basal epithelial cells and the number of keratocytes were evaluated.RESULTS. There was no significant difference between the cell density of superficial epithelial cells in buphthalmic eyes relative to healthy eyes (P ¼ 0.1944). The cell density of basal epithelial cells was significantly higher (P ¼ 0.0234) and the cell area was significantly smaller (P ¼ 0.0181) in buphthalmic eyes relative to healthy eyes. There was no difference between the number of keratocytes in buphthalmic eyes and healthy eyes in the anterior stroma (P ¼ 0.273) or in the posterior stroma (P ¼ 0.0799). The cell density of endothelial cells was significantly lower and the cell area was significantly larger in buphthalmic eyes relative to healthy eyes (P ¼ 0.0009). CONCLUSIONS.We demonstrated a lower cell density of endothelial cells in buphthalmic eyes. We found no differences in keratocyte density between the buphthalmic eyes and healthy eyes. The cell density of basal epithelial cells was higher in buphthalmic eyes. These differences could be due to buphthalmos or due to the previous surgical and medical therapies. Monitoring of these changes could help to contribute to accurate assessments regarding future ocular surgical procedures.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Corneal Changes Assessed Using Confocal Microscopy in Patients With Unilateral Buphthalmos

Mahelková

Filouš

Odehnal

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…was clearly visualized with evident thin and reflective nerve fibers and without abnormal branching. 7 However, the small number of patients did not allow a quantitive analysis of the nerve plexus morphology. In our study, we investigated the morphology of corneal subbasal nerve plexus in young patients with PCG and demonstrated that both the nerve density (2108 ± 692 mm) and the total number of nerve fibers (12.3 ± 4.2) are significantly decreased.…”

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confidence: 99%

Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma

Gatzioufas

Labiris

Hafezi

et al. 2014

Eye

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Background To quantify the corneal subbasal nerve density and the total number of nerve fibers in primary congenital glaucoma (PCG) and to evaluate their impact on corneal sensitivity. Methods Forty eyes of 26 PCG patients were compared with 40 eyes randomly selected from 40 non-glaucoma patients who populated the control group. Central corneal sensitivity (CCS) was assessed by means of Cochet-Bonnet esthesiometry. The mean subbasal nerve density and the total number of nerve fibers were quantified by laserscanning confocal microscopy. Normality of data was assessed by Kolmogorov-Smirnov testing. Differences in parameters were assessed with Student's t-test, while correlations with CSS were assessed with Pearson's correlation. Results Significant differences were identified in the mean subbasal nerve density (2108 ± 692 mm in PCG, 2642 ± 484 mm in controls, P ¼ 0.003) and in the total number of nerve fibers (12.3±4.2 in PCG, 15.4±3.1 in controls, P ¼ 0.02). Both groups presented comparable mean CCS and tortuosity. Both groups presented strong correlations between CCS and mean nerve density (r ¼ 0.57 in PCG, r ¼ 0.67 in controls, all Po0.05), and between CCS and total number of nerve fibers (r ¼ 0.55 in PCG, r ¼ 0.56 in controls, all Po0.05). Conclusion PCG exerts significant changes in both the mean subbasal nerve density and the total number of nerve fibers. However, these changes do not appear to affect central corneal sensitivity.

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Megalocornea

Fatima¹

2018

Encyclopedia of Ophthalmology

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In Vivo Confocal Microscopy in Primary Congenital Glaucoma With Megalocornea

Abstract: Confocal microscopy is a diagnostic tool used to evaluate microscopic aspects of Haab striae and endothelial morphologic changes in glaucomatous megalocornea. Unsuspected alterations, such as nerves abnormalities and focal endothelial tractions by scar tissue, were observed.

Cited by 46 publications

References 19 publications

Corneal Changes Assessed Using Confocal Microscopy in Patients With Unilateral Buphthalmos

Corneal Changes Assessed Using Confocal Microscopy in Patients With Unilateral Buphthalmos

Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma

Megalocornea

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