In vivo comparison of the proangiogenic properties of chlordecone and three of its dechlorinated derivatives formed by in situ chemical reduction

Alibrahim, E. Alabed; Legeay, Samuel; Billat, Pierre-André; Bichon, Emmanuelle; Guiffard, Ingrid; Antignac, Jean-Philippe; Legras, Pierre; Roux, J.; Bristeau, Sébastien; Clere, Nicolas; Faure, Sébastien; Mouvet, Christophe

doi:10.1007/s11356-019-04353-5

Cited by 3 publications

(3 citation statements)

References 46 publications

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“…Crude incidence, cases/100,000 male inhabitants Crude mortality, deaths/100,000 male inhabitants Ratio mortality to incidence, % environmental pollutants linked to the PCa development [41]. Another environmental pollutant is the widely discussed Bisphenol A (BPA) also studied in context of PCa.…”

Section: Countrymentioning

confidence: 99%

Prostate cancer management: long-term beliefs, epidemic developments in the early twenty-first century and 3PM dimensional solutions

Kučera¹,

Pecen²,

Topolčan³

et al. 2020

EPMA Journal

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In the early twenty-first century, societies around the world are facing the paradoxal epidemic development of PCa as a non-communicable disease. PCa is the most frequently diagnosed cancer for men in several countries such as the USA. Permanently improving diagnostics and treatments in the PCa management causes an impressive divergence between, on one hand, permanently increasing numbers of diagnosed PCa cases and, on the other hand, stable or even slightly decreasing mortality rates. Still, aspects listed below are waiting for innovate solutions in the context of predictive approaches, targeted prevention and personalisation of medical care (PPPM / 3PM). PCa belongs to the cancer types with the highest incidence worldwide. Corresponding economic burden is enormous. Moreover, the costs of treating PCa are currently increasing more quickly than those of any other cancer. Implementing individualised patient profiles and adapted treatment algorithms would make currently too heterogeneous landscape of PCa treatment costs more transparent providing clear “road map” for the cost saving. PCa is a systemic multi-factorial disease. Consequently, predictive diagnostics by liquid biopsy analysis is instrumental for the disease prediction, targeted prevention and curative treatments at early stages. The incidence of metastasising PCa is rapidly increasing particularly in younger populations. Exemplified by trends observed in the USA, prognosis is that the annual burden will increase by over 40% in 2025. To this end, one of the evident deficits is the reactive character of medical services currently provided to populations. Innovative screening programmes might be useful to identify persons in suboptimal health conditions before the clinical onset of metastasising PCa. Strong predisposition to systemic hypoxic conditions and ischemic lesions (e.g. characteristic for individuals with Flammer syndrome phenotype) and low-grade inflammation might be indicative for specific phenotyping and genotyping in metastasising PCa screening and disease management. Predictive liquid biopsy tests for CTC enumeration and their molecular characterisation are considered to be useful for secondary prevention of metastatic disease in PCa patients. Particular rapidly increasing PCa incidence rates are characteristic for adolescents and young adults aged 15–40 years. Patients with early onset prostate cancer pose unique challenges; multi-factorial risks for these trends are proposed. Consequently, multi-level diagnostics including phenotyping and multi-omics are considered to be the most appropriate tool for the risk assessment, prediction and prognosis. Accumulating evidence suggests that early onset prostate cancer is a distinct phenotype from both aetiological and clinical perspectives deserving particular attention from view point of 3P medical approaches.

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Section: Countrymentioning

confidence: 99%

Prostate cancer management: long-term beliefs, epidemic developments in the early twenty-first century and 3PM dimensional solutions

Kučera¹,

Pecen²,

Topolčan³

et al. 2020

EPMA Journal

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“…No in vitro tests have shown any greater toxicity in the degradates compared to the parent compound, and several tests have even shown that toxicity decreases as CLD dechlorination proceeds (Legeay et al, 2018). An in vivo test, which matched the human model most closely (Alibrahim et al, 2019), showed a significant decrease in toxicity for CLD-3Cl and CLD-4 Cl compared to CLD.…”

Section: Discussionmentioning

confidence: 99%

Physico-chemical and agronomic results of soil remediation by In Situ Chemical Reduction applied to a chlordecone-contaminated nitisol at plot scale in a French Caribbean banana plantation

Mouvet

Collet²,

Gaude³

et al. 2020

Environ Sci Pollut Res

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“…In the absence of complete mineralization, there is always a risk that the byproducts may retain a similar toxicity or acquire a higher toxicity than the parent molecule (Benoit et al 2017;Dol ng et al 2012). To answer this question, the genotoxic, mutagenic and proangiogenic properties of 3 major CLD derivatives, formed during the ISCR process (i.e., isomers having lost 1, 3 and 4 chlorine atoms), were compared to those of CLD (Alibrahim et al 2020;Legeay et al 2017). These studies showed that, like CLD, these derivatives were non-genotoxic and non-mutagenic, while their proangiogenic properties tested both in vitro and in vivo were strongly reduced.…”

Section: Introductionmentioning

confidence: 99%

Hydra bioassay for the evaluation of chlordecone toxicity at environmental concentrations, alone or in complex mixtures with dechlorinated byproducts: experimental observations and modeling by experimental design

Moreau

Claeys‐Bruno

Jean-Pascal

et al. 2022

Environ Sci Pollut Res

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In chlordecone (CLD) contaminated soils of the French West Indies, if microbial remediation or a physicochemical remediation process, e.g., in situ chemical reduction, is implemented, concentrations of degradation byproducts, such as hydrochlordecones, are expected to increase in the ecosystems. To study their impact in mixtures with CLD, bioassays were carried out. They consisted in evaluating the regenerative capacity of hydra polyps, from a clone whose phylogenetic analysis con rmed that it belonged to the species Hydra vulgaris Pallas, 1766. Hydra gastric sections were exposed to CLD alone or CLD plus dechlorinated byproducts (CLD-BPs) for 96 h to assess regeneration. Based on chromatographic analysis, the CLD-BPs mix was composed of the 5-monohydrochlordecone isomer (CAS nomenclature), four dihydrochlordecone isomers and one trihydrochlordecone isomer representing 50%, 47% and 3% of the total chromatographic area, respectively. A total of 18 mixtures of CLD and CLD-BPs were tested. Six environmental concentrations of CLD (2.10 − 4 µM to 4.10 − 2 µM) and a similar range of CLD-BPs were used. Results from exposures to CLD alone showed: (i) a signi cant decrease in the regenerative capacity of hydra, except at the lowest concentration (2.10 − 4 µM), (ii) a concentrationindependent deleterious effect. The regeneration scores obtained after the exposure to the addition of CLD-BPs were not signi cantly different from those obtained after exposure to CLD alone. Using an experimental design, a modeling of the regeneration scores of hydra exposed to mixtures is proposed.Interpreted carefully, since they are limited to only one type of bioassay, the present results suggest that the situation in the aquatic environments should not become worse in terms of toxicity, if soil remediation programs resulting in the formation of hydrochlordecones are put in place.

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In vivo comparison of the proangiogenic properties of chlordecone and three of its dechlorinated derivatives formed by in situ chemical reduction

Abstract: The results presented here were obtained through financing by the French Ministry of Environment, General directorate for risk prevention (action F of the 2015 grant program MEDDE/BRGM).

Cited by 3 publications

References 46 publications

Prostate cancer management: long-term beliefs, epidemic developments in the early twenty-first century and 3PM dimensional solutions

Prostate cancer management: long-term beliefs, epidemic developments in the early twenty-first century and 3PM dimensional solutions

Physico-chemical and agronomic results of soil remediation by In Situ Chemical Reduction applied to a chlordecone-contaminated nitisol at plot scale in a French Caribbean banana plantation

Hydra bioassay for the evaluation of chlordecone toxicity at environmental concentrations, alone or in complex mixtures with dechlorinated byproducts: experimental observations and modeling by experimental design

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