In vivo comparison of delayed gadolinium-enhanced MRI of cartilage and delayed quantitative CT arthrography in imaging of articular cartilage

Hirvasniemi, Jukka; Kulmala, K.A.M.; Lammentausta, Eveliina; Ojala, Risto; Lehenkari, Petri; Kamel, Ahmed; Jurvelin, Jukka S.; Töyräs, Juha; Nieminen, Miika T.; Saarakkala, Simo

doi:10.1016/j.joca.2012.12.009

Cited by 39 publications

(46 citation statements)

References 52 publications

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“…Use of dGEMRIC includes a 90 min delay to allow sufficient diffusion into articular cartilage, while exercise, joint loading and cartilage thickness influence uptake [236,237]. Studies using ioxaglate/gadopentetate mixtures for concurrent CT arthrography/dGEMRIC imaging in man show that dual modality imaging is achievable [92,244,245], but ICM alters anticipated MR signal intensity [246,247]. A recently developed cationic agent shows better penetration at 10% the dose of an anionic GCM and holds promise for improved dGEMRIC techniques [243].…”

Section: Techniques/usesmentioning

confidence: 99%

Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities

Nelson

Goodrich

Barrett

et al. 2017

Equine Veterinary Journal

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The use of contrast media in computed tomography (CT) and magnetic resonance imaging (MRI) is increasing in horses. These contrast-enhanced imaging techniques provide improved tissue delineation and evaluation, thereby expanding diagnostic capabilities. While generally considered safe, not all contrast media exhibit the same safety profiles. The safety of contrast media use and descriptions of adverse events occurring in horses are sparsely reported. This review summarises the reported evidence of contrast media use and adverse events that occur in horses, with added contribution from other veterinary species and studies in man for comparison. This comprehensive data set empowers equine clinicians to develop use and monitoring strategies when working with contrast media. Finally, it summarises the current state-of-the-art and highlights the potential applications of contrast-enhanced CT and MRI for assessment of diseased or injured equine tissues, as well as (patho)physiological processes.

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Section: Techniques/usesmentioning

confidence: 99%

Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities

Nelson

Goodrich

Barrett

et al. 2017

Equine Veterinary Journal

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“…This study shows that high resolution fast imaging with µCT can quantitatively measure the GAG over topographical locations in ex vivo cartilage. A recent work also showed the use of µCT to determine GAG in both in vivo and ex vivo cartilage based upon time-dependent equilibria of a contrast agent (44). The potential for human diagnosis in clinics has been demonstrated (45,46).…”

Section: Post-contrast μMri and μCtmentioning

confidence: 99%

Topographical and depth-dependent glycosaminoglycan concentration in canine medial tibial cartilage 3 weeks after anterior cruciate ligament transection surgery—a microscopic imaging study

Mittelstaedt¹,

Kahn²,

Xia³

2016

Quant. Imaging Med. Surg.

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Background: Medical imaging has become an invaluable tool to diagnose damage to cartilage. Depletion of glycosaminoglycans (GAG) has been shown to be one of the early signs of cartilage degradation. In order to investigate the topographical changes in GAG concentration caused by the anterior cruciate ligament transection (ACLT) surgery in a canine model, microscopic magnetic resonance imaging (µMRI) and microscopic computed tomography (µCT) were used to measure the GAG concentration with correlation from a biochemical assay, inductively coupled plasma optical emission spectroscopy (ICP-OES), to understand where the topographical and depth-dependent changes in the GAG concentration occur.Methods: This study used eight knee joints from four canines, which were examined 3 weeks after ACLT surgery. From right (n=3) and left (n=1) medial tibias of the ACLT and the contralateral side, two ex vivo specimens from each of four locations (interior, central, exterior and posterior) were imaged before and after equilibration in contrast agents. The cartilage blocks imaged using µMRI were approximately 3 mm × 5 mm and were imaged before and after eight hours submersion in a gadolinium (Gd) contrast agent with an in-plane pixel resolution of 17.6 µm 2 and an image slice thickness of 1 mm. The cartilage blocks imaged using µCT were approximately 2 mm × 1 mm and were imaged before and after 24 hours submersed in ioxaglate with an isotropic voxel resolution of 13.4 µm 3 . ICP-OES was used to quantify the bulk GAG at each topographical location.Results: The pre-contrast µMRI and µCT results did not demonstrate significant differences in GAG between the ACLT and contralateral cartilage at all topographical locations. The post-contrast µMRI and µCT results demonstrated topographically similar significant differences in GAG concentrations between the ACLT and contralateral tibia. Using µMRI, the GAG concentrations (mg/mL) were measured for the ACLT and contralateral respectively, the exterior (54.0±3.

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“…Several computed tomography (CT) studies have addressed the visualization of micro‐structure of AC matrix using various contrast agents (CA4+, CA2+, Tantalum Oxide nanoparticles, Hexabrix®, Magnevist®) . Phase‐contrast synchrotron CT is also able to reveal the micro‐structure of the AC matrix .…”

mentioning

confidence: 99%

Quantifying Complex Micro‐Topography of Degenerated Articular Cartilage Surface by Contrast‐Enhanced Micro‐Computed Tomography and Parametric Analyses

Ylitalo

Finnilä

Gahunia³

et al. 2019

Journal Orthopaedic Research

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One of the earliest changes in osteoarthritis (OA) is a surface discontinuity of the articular cartilage (AC), and these surface changes become gradually more complex with OA progression. We recently developed a contrast enhanced micro‐computed tomography (μCT) method for visualizing AC surface in detail. The present study aims to introduce a μCT analysis technique to parameterize these complex AC surface features and to demonstrate the feasibility of using these parameters to quantify degenerated AC surface. Osteochondral plugs ( n = 35) extracted from 19 patients undergoing joint surgery were stained with phosphotungstic acid and imaged using μCT. The surface micro‐topography of AC was analyzed with developed method. Standard root mean square roughness (R q ) was calculated as a reference, and the Area Under Curve (AUC) for receiver operating characteristic analysis was used to compare the acquired quantitative parameters with semi‐quantitative visual grading of μCT image stacks. The parameters quantifying the complex micro‐topography of AC surface exhibited good sensitivity and specificity in identifying surface continuity (AUC: 0.93, [0.80 0.99]), fissures (AUC: 0.94, [0.83 0.99]) and fibrillation (AUC: 0.98, [0.88 1.0]). Standard R q was significantly smaller compared with the complex roughness (CR q ) already with mild surface changes with all surface reference parameters − continuity, fibrillation, and fissure sum. Furthermore, only CR q showed a significant difference when comparing the intact surface with lowest fissure sum score. These results indicate that the presented method for evaluating complex AC surfaces exhibit potential to identify early OA changes in superficial AC and is dynamic throughout OA progression. © 2019 The Authors. Journal of Orthopaedic Research ® Published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. Society. 9999:1–12, 2019.

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In vivo comparison of delayed gadolinium-enhanced MRI of cartilage and delayed quantitative CT arthrography in imaging of articular cartilage

Cited by 39 publications

References 52 publications

Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities

Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities

Topographical and depth-dependent glycosaminoglycan concentration in canine medial tibial cartilage 3 weeks after anterior cruciate ligament transection surgery—a microscopic imaging study

Quantifying Complex Micro‐Topography of Degenerated Articular Cartilage Surface by Contrast‐Enhanced Micro‐Computed Tomography and Parametric Analyses

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