In vivo cholesterol synthesis by the rat digestive tract. III. Evaluation of modulating factors

Lutton, C.; Perrodin, Martine; Cardona-Sanclemente, L. E.; Sérougne, Colette

doi:10.1051/rnd:19860902

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Let us underline that in CH,F rats, the amount of enterocyte cholesterol seems to increase slightly from crypt to apical cells at all sites of the small intestine, suggesting a small increase in the size of the enterocyte during its migration on the vil lus. The mean cholesterol content of B and CH rats were 0.54 ± 0.01 (n = 96) and 0.78 ± 0.04 (n = 34), respective ly, showing a 20 and 73% increase in the mucosal choles terol content during cholesterol absorption [3].…”

Section: Cholesterol Content Of the Intestinal M Ucosa: Anatom Ical Dmentioning

confidence: 89%

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Anatomical Heterogeneity of the Intestinal Mucosa and Cholesterol Homeostasis

Lutton¹

1996

Digestion

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Quantitative data on cholesterol movements in mucosa cell as a function of its localization in the small intestine have been obtained in normocholesterolemic (SW) or genetically hypercholesterolemic (RICO) rats. Bile cholesterol absorption is greater and more proximal than dietary cholesterol absorption, both taking place mainly in the top cells of the duodenum or the proximal jejunum. Esterification of cholesterol also takes place mainly in the villus cells, while cholesterol synthesis is predominantly carried out in the crypt cells of the proximal duodenum and distal ileum. Cholesterol exchanges, which replace half of the cell cholesterol throughout the cell life, can be estimated at 3-4% •h^-1 between plasma and mucosa cells, according to its location, i.e. 12-25 μg·h^-1 (per mg cell DNA). In comparison, the cholesterol HDL or LDL uptake appears to be very low (0.02-0.06 and 0.2-0.6 μg·h^-1, respectively). Compartmentalization of cholesterol metabolism in the enterocyte can be suggested by different experimental data. The turnover of newly synthesized cholesterol is about 2-fold lower than that of exogenous (dietary) cholesterol.

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Section: Cholesterol Content Of the Intestinal M Ucosa: Anatom Ical Dmentioning

confidence: 89%

“…In order to assess the importance of dietary sterol in determining the cholesterol content of the villus, several studies have examined cholesterol content in normal ver sus cholesterol-enriched diets [3][4][5][6].…”

Section: Cholesterol Content Of the Intestinal M Ucosa: Anatom Ical Dmentioning

confidence: 99%

Anatomical Heterogeneity of the Intestinal Mucosa and Cholesterol Homeostasis

Lutton¹

1996

Digestion

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“…Thus, cholesterol synthesis and HDL uptake seem to be regulated independently in the rat small intestinal mucosa. (Gut 1994;35: 343-346) Methods ANIMALS These studies were performed with male normocholesterolaemic (SW) and genetically hypercholesterolaemic (RICO) rats weighing mean (SD) 430 (20) The small intestine plays a key role in cholesterol balance. '2 It is an active site for cholesterogenesis'3 but in contrast to cholesterol absorption, which occurs predominantly in the upper villus cells of the proximal intestine, cholesterol synthesis take place predominantly in the duodenal and ileal crypts.…”

Section: Introductionmentioning

confidence: 99%

Cholesterol synthesis and high density lipoprotein uptake are regulated independently in rat small intestinal epithelium.

Lutton

Champarnaud

1994

Gut

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The rates of high density lipoprotein HDL uptake and cholesterol synthesis were compared in the normocholesterolaemic (SW) The small intestine plays a key role in cholesterol balance.'2 It is an active site for cholesterogenesis'3 but in contrast to cholesterol absorption, which occurs predominantly in the upper villus cells of the proximal intestine, cholesterol synthesis take place predominantly in the duodenal and ileal crypts.4 5 In addition to its role in cholesterol absorption and synthesis, the intestine also seems to be an important site for the clearance of cholesterol from the plasma through low density lipoprotein (LDL) uptake.6 The rates of sterol synthesis and LDL uptake, however, seem to be independently regulated in the rat small intestinal epithelium.

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