In vivo characterization of the interface between cortical bone and biphasic calcium phosphate by the PIXE method

Abstract

The aim of this study is to evaluate the resorption of a calcium phosphate ceramic composed of 75% hydroxyapatite and 25% β‐tricalcium phosphate (HTCP) used as a biomaterial. The animal implantation has been made in the cortical femur of sheep. Delays of 2, 4, 8, 12, 16, 20, 28, 36 and 48 weeks between graft and analysis were used. The samples were a section of cortical bone containing the implant. The mechanism of bioceramic degradation was studied by the particle‐induced x‐ray emission (PIXE) method. The bone/implant interface was analysed and Ca, P, Zn, Fe and Sr were measured for the nine delay periods. We found a discontinuity of elemental concentration at the interface. Thus, we observed evolution of the concentration of each element in HTCP according to time after implantation. Then we determined the kinetics of resorption. Copyright © 1999 John Wiley & Sons, Ltd.

STEM and EDXS Characterization of Physico‐chemical Reactions at the Periphery of Bioactive Glass Particles in Contact with Biological Fluids

“…In orthopaedic and dental applications, calcium phosphate based ceramics, glass ceramics and bioactive glasses have been used by virtue of their ability to bond directly with bone tissues and to promote bone formation 1 . This property has become known as bioactivity.…”

Study of new sheep bone and Zn/Ca ratio around TiAlV screw: PIXE–RBS analysis

“…Examination of bone and osseointegration around an implant are frequently realized with techniques such as histological observation, histomorphometry, fluorescent microscopy and scanning electron microscopy [24][25][26][27]. RBS and PIXE analysis are complementary techniques for analysis of the implant-bone interface [28][29][30][31]. The advantages of PIXE analysis are the ability to make multiple-elemental maps with a good spatial resolution (in the order of lm) and to detect various trace elements simultaneously with good sensitivity [32].…”

Matriz ossea inorganica e propriedades da interface fosfatos de calcio/soluções aquosas

“…Embora os estudos realizados sobre os fosfatos de cálcio, até o momento, tenham resultado em um grande volume de informações sobre biocerâmicas por eles constituídas, ainda não foi possível explicar quais são os fenômenos e características que determinam a biocompatibilidade destes materiais. Tem sido reportado com freqüência que as propriedades ligadas à biocompatibilidade destas biocerâmicas, devem-se mais a propriedades de sua superfície e de como ela se modifica ao longo do tempo após ser implantada, do que as características do "bulk" [63][64][65][66][67] .6 364656667…”