“…To address the issues of postoperational ischemia and angiogenesis, biodegradable microspheres were developed which are either synthetic or extracted from natural sources (Mao et al, 2012). Natural biodegradable microspheres include starch microspheres (Gross & Albrecht, 2020; Orlacchio et al, 2020; Sommer et al, 2018; Yamasaki et al, 2012), silk fibroin (SF)/elastin (Figure 3) (Chen et al, 2020; Poursaid et al, 2015; Poursaid, Jensen, Nourbakhsh, et al, 2016), gelatin microspheres (Katsumori et al, 2017; Sakuhara et al, 2019), alginate (Xuan et al, 2017; Zeng et al, 2018), carrageenan (Liu et al, 2020), and Bletilla striata (Luo et al, 2019).…”