In vivo cation transport during short‐term and long‐term digoxin therapy.

Boon, Nicholas A.; Pugh, S.; Hallis, K F; Aronson, Jeff; Grahame‐Smith, D. G.

doi:10.1111/j.1365-2125.1986.tb02875.x

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Another possible explanation is that ouabain was rapidly cleared by ciliary clearance mechanisms, but if this were the case amiloride would likewise have been ineffective. Inadequate drug penetration is unlikely to explain the lack of effect of oral digoxin, however, as a similar plasma concentration to those obtained in this study has previously been shown to cause widespread inhibition of tissue Na+-K+-ATPase in healthy subjects [31] after a similar length of treatment. Although a small rise in nasal P D was seen after the first week of digoxin, the increase was not statistically significant and was absent by the second week.…”

Section: Discussionsupporting

confidence: 77%

“…Oral digoxin has a peak cardiac effect at 5h, with a half-life of 36h [22]. After short-term administration (over days to weeks), digoxin produces widespread inhibition of cardiac Na+-K+-ATPase, although after several months this effect may be lost due to pump upregulation [31]. The effect of digoxin on nasal PD was investigated over 2weeks to avoid this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Oral Digoxin, Topical Ouabain and Salbutamol on Transepithelial Nasal Potential Difference in Patients with Cystic Fibrosis

et al. 1995

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1. Airway epithelium in cystic fibrosis is characterized by a defect in chloride secretion across the apical membrane and an increase in sodium absorption. The increased rate of sodium absorption can be inhibited in vitro by ouabain, a Na(+)-K(+)-ATPase inhibitor, and in cystic fibrosis patients the number and activity of nasal epithelial Na(+)-K(+)-ATPase pumps is increased. 2. We have performed a series of studies to determine whether drugs which modify airway epithelial Na(+)-K(+)-ATPase activity in vitro can modify nasal potential in cystic fibrosis patients in vivo. As transepithelial nasal potential difference measurements were used to study the effect of drug modulation of airway epithelial ion transport in vivo, the repeatability of the technique was first evaluated. In order to assess the effectiveness of the technique used for measuring nasal potential difference, a pilot study was carried out using topical amiloride, a drug which has previously been shown to inhibit airway epithelium sodium transport in vivo. We then studied the effects of ouabain and digoxin, two inhibitors of Na(+)-K(+)-ATPase, on nasal potential difference. 3. In study 1, nasal potential difference measurements were repeated on non-consecutive days in 20 patients with cystic fibrosis and 20 healthy individuals. Healthy subjects had a mean (SEM) potential difference value of -19.5 (0.9) mV with a 95% range for a single estimate of 75-133%. In patients with cystic fibrosis, the mean (SEM) potential difference was -40.4, (2.1) mV, with a 95% range for a single estimate of 74-136%.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Effect of Oral Digoxin, Topical Ouabain and Salbutamol on Transepithelial Nasal Potential Difference in Patients with Cystic Fibrosis

et al. 1995

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“…In an attempt to overcome the difficulties associated with measures in vitro, we have developed a technique which allows the assessment of cation transport in vivo [ 171. This has already been used to demonstrate differences in sodium pump activity in patients suffering from hypertension [18] and chronic renal failure [17] and during treatment with digoxin [17,19]. We have now used this technique in vivo to assess the effect of treatment with lithium salts upon cation transport in healthy volunteers.…”

Section: Introductionmentioning

confidence: 99%

Measurement of cation transport in vivo in healthy volunteers after the oral administration of lithium carbonate

Wood¹,

Glue²,

Aronson³

et al. 1989

Clinical Science

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1. We have measured cation transport in vivo in seven healthy volunteers under control conditions and after they had taken lithium carbonate for 21 days in doses which maintained the serum lithium concentration in the range 0.6-0.8 mmol/l. 2. We have measured cation transport in vivo after the administration of an oral load of rubidium chloride, and have found that, although intra-erythrocytic concentrations of rubidium were significantly lower 1 h after the administration of rubidium when the subjects were taking lithium, there was a significant increase in the rate of uptake of rubidium into the erythrocytes over the subsequent period of the test, suggesting a direct stimulation of sodium, potassium-activated adenosine triphosphatase by lithium. 3. Lithium administration did not affect the plasma concentration versus time profile of rubidium after the rubidium load, implying that the lithium-stimulated uptake of rubidium which occurs in erythrocytes does not necessarily occur in other cell types. 4. These results suggest that previous studies of cation transport using peripheral cells and assay systems in vitro do not necessarily reflect changes in cation transport in vivo in excitable tissues.

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Reversible inhibition of leucocyte sodium pumps by a circulating serum factor in essential hypertension.

Finotti¹

1986

BMJ

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In vivo cation transport during short‐term and long‐term digoxin therapy.

Cited by 3 publications

References 9 publications

Effect of Oral Digoxin, Topical Ouabain and Salbutamol on Transepithelial Nasal Potential Difference in Patients with Cystic Fibrosis

Effect of Oral Digoxin, Topical Ouabain and Salbutamol on Transepithelial Nasal Potential Difference in Patients with Cystic Fibrosis

Measurement of cation transport in vivo in healthy volunteers after the oral administration of lithium carbonate

Reversible inhibition of leucocyte sodium pumps by a circulating serum factor in essential hypertension.

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