In vivo biodistribution of platinum-based drugs encapsulated into multi-walled carbon nanotubes

Li, Jian; Pant, Aakanksha; Chin, Chee Fei; Ang, Wee Han; Ménard‐Moyon, Cécilia; Nayak, Tapas R.; Gibson, Dan; Ramaprabhu, Sundara; Pańczyk, Tomasz; Bianco, Alberto; Pastorin, Giorgia

doi:10.1016/j.nano.2014.01.004

Cited by 57 publications

(49 citation statements)

References 53 publications

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“…3, 4 Studies also showed that dispersion stability and loading conditions could influence MWCNTs-induced therapeutic effects as well as the efficiency of a loaded drug. 5 However, such studies failed to reduce the MWCNTs-induced inflammatory effects 6 or to resolve the overall mechanisms of toxicity associated with MWCNTs cellular uptake.…”

Section: Introductionmentioning

confidence: 99%

Towards elucidating the effects of purified MWCNTs on human lung epithelial cells

Dong

Eldawud

Sargent

et al. 2014

Environ. Sci.: Nano

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Toxicity of engineered nanomaterials is associated with their inherent properties, both physical and chemical. Recent studies have shown that exposure to multi-walled carbon nanotubes (MWCNTs) promotes tumors and tumor-associated pathologies and lead to carcinogenesis in model in vivo systems. Here in we examined the potential of purified MWCNTs used at occupationally relevant exposure doses for particles not otherwise regulated to affect human lung epithelial cells. The uptake of the purified MWCNTs was evaluated using fluorescence activated cell sorting (FACS), while the effects on cell fate were assessed using 2- (4-iodophenyl) - 3- (4-nitrophenyl) - 5-(2, 4-disulfophenyl) -2H-tetrazolium salt colorimetric assay, cell cycle and nanoindentation. Our results showed that exposure to MWCNTs reduced cell metabolic activity and induced cell cycle arrest. Our analysis further emphasized that MWCNTs-induced cellular fate results from multiple types of interactions that could be analyzed by means of intracellular biomechanical changes and are pivotal in understanding the underlying MWCNTs-induced cell transformation.

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Section: Introductionmentioning

confidence: 99%

Towards elucidating the effects of purified MWCNTs on human lung epithelial cells

Dong

Eldawud

Sargent

et al. 2014

Environ. Sci.: Nano

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“…In general, these previous studies focused on encapsulation of cisplatin or cisplatin derivatives within the lumen of CNTs as a strategy to prevent premature drug activation and for slow drug release following cell uptake. [13, 15–17] Alternatively, other CNT-based platinum chemotherapy delivery systems rely on covalent attachment to tether the functional platinum group to the CNT surface via a cleavable linker. [14, 18, 19] While these studies clearly demonstrate the capacity of using CNT for targeted drug delivery and controlled release, further clinical development may be hampered due to reliance on intracellular cleavage and modification of the platinum complex for activation, complicated linker synthesis, or inherent problems common to classical platinum pharmacophores.…”

Section: Discussionmentioning

confidence: 99%

Design and cellular studies of a carbon nanotube-based delivery system for a hybrid platinum-acridine anticancer agent

Fahrenholtz

Ding

Bernish

et al. 2016

Journal of Inorganic Biochemistry

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A three-component drug-delivery system has been developed consisting of multi-walled carbon nanotubes (MWCNTs) coated with a non-classical platinum chemotherapeutic agent ([PtCl(NH3)2(L)]Cl (P3A1; L = N-(2-(acridin-9-ylamino)ethyl)-N-methylproprionimidamide) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-5000] (DSPE-mPEG). The optimized P3A1-MWCNTs are colloidally stable in physiological solution and deliver more P3A1 into breast cancer cells than treatment with the free drug. Furthermore, P3A1-MWCNTs are cytotoxic to several cell models of breast cancer and induce S-phase cell cycle arrest and non-apoptotic cell death in breast cancer cells. By contrast, free P3A1 induces apoptosis and allows progression to G2/M phase. Photothermal activation of P3A1-MWCNTs to generate mild hyperthermia potentiates their cytotoxicity. These findings suggest that delivery of P3A1 to cancer cells using MWCNTs as a drug carrier may be beneficial for combination cancer chemotherapy and photothermal therapy.

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“…It has been demonstrated that CNTs support the growth of osteoblastic cells by stimulating the production of extracellular matrix (ECM), a central step during the formation of bone tissue . Furthermore, CNTs could be a more effective drug delivery carrier due to their external functionalizable surface and their hollowed cavity that can encapsulate several bioactive molecules …”

Section: Discussionmentioning

confidence: 99%

The application of nanomaterials in controlled drug delivery for bone regeneration

Shi

Jiang

Zhao

et al. 2015

J Biomedical Materials Res

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Bone regeneration is a complicated process that involves a series of biological events, such as cellular recruitment, proliferation and differentiation, and so forth, which have been found to be significantly affected by controlled drug delivery. Recently, a lot of research studies have been launched on the application of nanomaterials in controlled drug delivery for bone regeneration. In this article, the latest research progress in this area regarding the use of bioceramics-based, polymer-based, metallic oxide-based and other types of nanomaterials in controlled drug delivery for bone regeneration are reviewed and discussed, which indicates that the controlling drug delivery with nanomaterials should be a very promising treatment in orthopedics. Furthermore, some new challenges about the future research on the application of nanomaterials in controlled drug delivery for bone regeneration are described in the conclusion and perspectives part. V C 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3978-3992, 2015.

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In vivo biodistribution of platinum-based drugs encapsulated into multi-walled carbon nanotubes

Cited by 57 publications

References 53 publications

Towards elucidating the effects of purified MWCNTs on human lung epithelial cells

Towards elucidating the effects of purified MWCNTs on human lung epithelial cells

Design and cellular studies of a carbon nanotube-based delivery system for a hybrid platinum-acridine anticancer agent

The application of nanomaterials in controlled drug delivery for bone regeneration

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