In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation

He, Qianjun; Zhang, Zhiwen; Gao, Fang; Li, Yaping; Shi, Jianlin

doi:10.1002/smll.201001459

Cited by 577 publications

(525 citation statements)

References 39 publications

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“…The biocompatibility of MSNs and several carbon-based biomaterials (e.g., carbon nanotubes and graphene) have been systematically investigated using several metrics, including biodistribution, excretion, biodegradation, histocompatibility, and hemocompatibility [102][103][104][105][106][107]. They have been demonstrated to be non-toxic at desirable doses.…”

Section: Biocompatibility Of Mcbsmentioning

confidence: 99%

Mesoporous carbon biomaterials

Chen

Shi

2015

Sci. China Mater.

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Nano-biotechnology provides highly efficient and versatile strategies to improve the diagnostic precision and therapeutic efficiency of serious diseases. The development of new biomaterial systems provides great opportunities for the successful clinical translation of nano-biotechnology for personalized biomedicine to benefit patients. As a new inorganic material system, mesoporous carbon biomaterials (

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Section: Biocompatibility Of Mcbsmentioning

confidence: 99%

Mesoporous carbon biomaterials

Chen

Shi

2015

Sci. China Mater.

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“…In vivo dissolution 414 He et al [62] evaluated the biodistribution, 415 biodegradation and excretion of MSNs with different 416 sizes (80-360 nm) and with or without PEG coating.…”

mentioning

confidence: 99%

Tuning mesoporous silica dissolution in physiological environments: a review

et al. 2017

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19Matrix degradation has a major impact on the release kinetics of drug delivery 20 systems. Regarding ordered mesoporous silica materials for biomedical appli-21 cations, their dissolution is an important parameter that should be taken into 22 consideration. In this paper, we review the main factors that govern the 23 mesoporous silica dissolution in physiological environments. We also provide 24 the necessary knowledge to researchers in the area for tuning the dissolution 25 rate of those matrices, so the degradation could be controlled and the material 26 behaviour optimised. 27 28 29 Introduction 30 Ordered mesoporous silica materials (OMS) have 31 received great attention by the biomedical scientific 32 community since they were proposed for the first 33 time as drug delivery systems by the research group 34 headed by Vallet-Regí et al. [1]. Their unique struc-35 tural and textural properties, such as tuneable pore 36 structure, large surface area and pore volume, con-37 trollable pore diameter and morphology, and func-38 tionalisable surface, make OMS excellent candidates 39 to be applied as drug delivery devices in different 40 biomedical applications [2][3][4][5]. 41Initially, OMS were purposed as bioceramics for 42 local drug delivery and bone tissue regenerations due 43 to their surface characteristics, such as biocompati-44 bility and bioactivity, and their capability to load and 45 release in a controlled fashion different therapeutic 46 cargoes for the treatment of diverse pathologies 47 (Fig. 1,t o (Fig. 1, bottom), 56 underlining their systemic administration as 57 nanocarriers for diagnosis and treatment of complex 58 diseases such as cancer [20][21][22][23][24][25]. 59 The degradability of different drug delivery devi-60 ces is a key parameter for their successful translation 61 to a clinical scenario. In this sense, dissolution has 62 profound implications in the mechanical properties 63 of materials used for bone filling. Most importantly,

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“…Mesoporous silica NP has also become a multifunctional delivery platform that has been shown at both in vitro and in vivo levels to be capable of delivering chemotherapeutic agents to a variety of cancer cell types (Lee et al 2009;Meng et al 2010;He et al 2011). The major advantage of using a mesoporous silica based carrier is that its internal ordered pore structures may be tailored to host differently sized drug molecules and its release profile can be predetermined.…”

Section: Nanomaterials In Drug Deliverymentioning

confidence: 99%

Nanomaterials for biomedical applications

Das

Mitra

Khurana

et al. 2013

Frontiers in Life Science

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Nanotechnology involves understanding and manipulating materials normally in the size range of 1 to 100 nm, where particles show completely novel physico-chemical properties from their bulk counterpart. In the last two decades a number of precisely engineered nanomaterials have been developed for diagnostic and therapeutic applications. For diagnostic applications, nanoparticles allow detection at the molecular scale. Some fluorescent nanohybrids can serve the dual purpose of detection and destruction of pathogenic microbes. The specificity and sensitivity of magnetic resonance imaging can be greatly improved by using nanoparticles as contrast enhancement material. As therapeutic agent, they allow targeted delivery and sustained release of drug molecules and they also have huge potential in tissue engineering. Given the vast range of application of nanomaterials in the biomedical domain, this review focuses on the major nanoparticle based diagnostic and therapeutic modalities.

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In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation

Cited by 577 publications

References 39 publications

Mesoporous carbon biomaterials

Mesoporous carbon biomaterials

Tuning mesoporous silica dissolution in physiological environments: a review

Nanomaterials for biomedical applications

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