In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering

Kang, Young Sook; Lee, Bit Na; Ko, Jae Hoon; Kim, Gyeong Hae; Kang, Kkot Nim; Kim, Da Yeon; Kim, Jae Ho; Park, Young Hwan; Chun, Heung Jae; Kim, Chun Ho; Kim, Moon Suk

doi:10.3390/ijms11104140

Cited by 36 publications

(25 citation statements)

References 22 publications

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“…Other researchers, after the implantation of the material containing chitosan in its constitution, also observed the formation of blood vessels in the area of the procedure (Azab et al, 2007;Brito et al, 2009;Kang et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

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In vivo biocompatibility of nanostructured Chitosan/Peo membranes

Vulcani

Franzo

Rabelo

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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In vivo biocompatibility of nanostructured Chitosan/Peo membranes ABSTRACTElectrospinning is a technique that allows the preparation of nanofibers from various materials. Chitosan is a natural and abundant easily obtained polymer, which, in addition to those features, proved to be biocompatible. This work used nanostructured chitosan and polyoxyethylene membranes as subcutaneous implants in Wistar rats to evaluate the biocompatibility of the material. Samples of the material and tissues adjacent to the implant were collected 7, 15, 30, 45 and 60 days post-implantation. Macroscopic integration of the material to the tissues was observed in the samples and slides for histopathological examination that were prepared. It was noticed that the material does not stimulate the formation of adherences to the surrounding tissues and that there is initial predominance of neutrophilia and lymphocytosis, with a declining trend according to the increase of time, featuring a non-persistent acute inflammatory process. However, the material showed fast degradation, impairing the macroscopic observation after fifteen days of implantation. It was concluded that the material is biocompatible and that new studies should be conducted, modifying the time of degradation by changes in obtaining methods and verifying the biocompatibility in specific tissues for biomedical applications.

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Section: Resultsmentioning

confidence: 99%

“…However, in another study, where the chitosan membrane was associated to stem cells, there was less inflammatory response when compared to the control group. This fact may be explained by the likely immunosuppression caused by the transplanted stem cells (Kang et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

In vivo biocompatibility of nanostructured Chitosan/Peo membranes

Vulcani

Franzo

Rabelo

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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“…Chitosan is a natural and abundant polymer that is an attractive candidate scaffolding material for tissue engineering [13,19]. Chitosan-based hydrogels have been shown to be biodegradable, non-immunogenic, and biocompatible, and therefore, they are widely used as a therapeutic scaffold for tissue engineering processes such as cell encapsulation and cell culture [27][28][29][30]. Recent studies have shown that a mixture of chitosan and glycerol phosphate disodium salt (GP) can form a hydrogel in situ at body temperature [13,31].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-based hydrogels to induce neuronal differentiation of rat muscle-derived stem cells

Kwon

Kim

et al. 2012

International Journal of Biological Macromolecules

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“…To this end, the development of adjuvant tissue engineering scaffolds have considerable promise, as they potentially offer synergy between the delivery/recruitment of cells, presentation of biochemical and physio-chemical cues, 3-D morphology and mechanical and topographical stimuli to improve or replace physiological function [7]. Within the past decade, a variety of 3-D tissue engineering scaffolds have emerged; for instance, fibrous scaffolds produced from a diverse range of polymers, both natural and synthetic, have been fabricated using a variety of methods, notably electrospinning [8][9][10]. These fibrous networks, through subsequent biochemical and physiochemical modification, may present appropriate stimuli for in vivo repair [11,12].…”

Section: Self-assembling Peptides As Biomaterials For In Vivo Applicamentioning

confidence: 99%

Self-Assembled Peptides: Characterisation and In Vivo Response

Nisbet

Williams

2012

Biointerphases

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The fabrication of tissue engineering scaffolds is a well-established field that has gained recent prominence for the in vivo repair of a variety of tissue types. Recently, increasing levels of sophistication have been engineered into adjuvant scaffolds facilitating the concomitant presentation of a variety of stimuli (both physical and biochemical) to create a range of favourable cellular microenvironments. It is here that self-assembling peptide scaffolds have shown considerable promise as functional biomaterials, as they are not only formed from peptides that are physiologically relevant, but through molecular recognition can offer synergy between the presentation of biochemical and physio-chemical cues. This is achieved through the utilisation of a unique, highly ordered, nano- to microscale 3-D morphology to deliver mechanical and topographical properties to improve, augment or replace physiological function. Here, we will review the structures and forces underpinning the formation of self-assembling scaffolds, and their application in vivo for a variety of tissue types.

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In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering

Cited by 36 publications

References 22 publications

In vivo biocompatibility of nanostructured Chitosan/Peo membranes

In vivo biocompatibility of nanostructured Chitosan/Peo membranes

Chitosan-based hydrogels to induce neuronal differentiation of rat muscle-derived stem cells

Self-Assembled Peptides: Characterisation and In Vivo Response

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