In vivo biocompatibility of porous silicon biomaterials for drug delivery to the heart

Tölli, Marja; Ferreira, Mónica P. A.; Kinnunen, Sini; Rysä, Jaana; Mäkilä, Ermei; Szabò, Zoltán; Serpi, Raisa; Ohukainen, Pauli; Välimäki, Mika J.; Correia, Alexandra; Salonen, Jarno; Hirvonen, Jouni; Ruskoaho, Heikki; Santos, Hélder A.

doi:10.1016/j.biomaterials.2014.05.078

Cited by 74 publications

(39 citation statements)

References 56 publications

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“…An in vivo experiment tested the biocompatibility of different sizes of thermally oxidized PSi nanoparticles in the heart tissue. Obvious changes in cardiac function and other systems like the hematological system were not found before and after MI, demonstrating that thermally oxidized PSi nanoparticles have good biocompatibility [56]. Other research concluded that functionalized undecylenic acid thermally carbonized PSi nanoparticles can improve their ability of accumulation in different cardiomyocytes (primary cardiomyocytes, noncardiomyocytes and H9C2 myocardium).…”

Section: Silicon Nanoparticlesmentioning

confidence: 97%

Nanoparticles for Postinfarct Ventricular Remodeling

Dong

Liu

2018

Nanomedicine (Lond.)

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In recent years, tremendous progress has been made in the treatment of acute myocardial infarction, but pathological ventricular remodeling often causes survivors to suffer from fatal heart failure. Currently, there is no effective therapy to attenuate ventricular remodeling. Recently, nanoparticle-based drug delivery systems are widely applied in biomedicine especially in cancer and liver fibrosis, owing to its excellent physical, chemical and biological properties. Therefore, the use of nanoparticles as delivery vehicles of small molecules, polypeptides, etc. to improve postinfarct ventricular remodeling is expected. In this review, we summarize the updated researches in this fast-growing area and suggest further works needed.

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Section: Silicon Nanoparticlesmentioning

confidence: 97%

Nanoparticles for Postinfarct Ventricular Remodeling

Dong

Liu

2018

Nanomedicine (Lond.)

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“…During the past decades, pSi has been widely used in orthopedic purpose and biomedical applications [17,[61][62][63], especially utilized as high-performance carriers for delivery of therapeutic agents to take advantages of their attractive properties, including large surface-to-volume ratio, excellent biocompatibility and biodegradability, and high loading efficiency, and so on. Since the early study of using pSi as carriers for insulin delivery [64], pSi has received great attention in drug delivery systems for loading conventional drugs (e.g., daunorubicin, indomethacin [IMC], methotrexate [MTX], sorafenib, DOX, atorvastatin and celecoxib, among others), genes (e.g., siRNA) and proteins (e.g., peptide, insulin, among others) [8,30,31,[65][66][67][68][69][70][71][72][73][74][75][76][77][78][79]. As far as 2006, Vaccari and coworkers loaded DOX molecules into pSi materials to treat human colon adenocarcinoma cancer cells [68].…”

Section: Silicon Nanomaterial-based Nanoagents For Cancer Therapymentioning

confidence: 99%

Silicon Nanostructures for Cancer Diagnosis and Therapy

Peng

Cao

et al. 2015

Nanomedicine (Lond.)

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The emergence of nanotechnology suggests new and exciting opportunities for early diagnosis and therapy of cancer. During the recent years, silicon-based nanomaterials featuring unique properties have received great attention, showing high promise for myriad biological and biomedical applications. In this review, we will particularly summarize latest representative achievements on the development of silicon nanostructures as a powerful platform for cancer early diagnosis and therapy. First, we introduce the silicon nanomaterial-based biosensors for detecting cancer markers (e.g., proteins, tumor-suppressor genes and telomerase activity, among others) with high sensitivity and selectivity under molecular level. Then, we summarize in vitro and in vivo applications of silicon nanostructures as efficient nanoagents for cancer therapy. Finally, we discuss the future perspective of silicon nanostructures for cancer diagnosis and therapy.

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“…PSi with desired physical and optical properties such as pore size, porosity, thickness, and reflectance can be easily tuned by varying current density and etching time. The prepared PSi layer can be removed from the Si substrate by electropolishing and subsequently fractured by ultrasonication or wet milling process to prepare micro-and nanoparticles [11][12][13]. The surface chemistry of PSi has a strong influence on the drug loading and its release behaviour in the biological systems.…”

Section: Introductionmentioning

confidence: 99%