In vivo behaviour of three calcium phosphate cements and a magnesium phosphate cement

Driessens, F. C. M.; Boltong, M. G.; Zapatero, M. I.; Verbeeck, Ronald; Bonfield, W.; Bermúdez, O.; Fernández, E.; Ginebra, Maria‐Pau; Planell, Josep A.

doi:10.1007/bf00120270

Cited by 48 publications

(29 citation statements)

References 28 publications

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“…HA bioceramic, stoichiometric HA or s‐HA, has been successfully synthesized Ca 10 (PO 4 ) 6 (OH) 2, by precipitating at high pH and sintering the precipitated product above 1000°C to have a similar stoichiometry (Ca:P ratio of 1.67) to BA (chemical formula Ca 10 (PO 4 ) 6 (OH) 2 [39.6% Ca and 18.5% P]). Such ratios (39.6% Ca and 18.5% P) found in mineralized tissue have close values to biological apatites that is, bone 1.65; dentin 1.67 and enamel 1.59 . Although the apatite has similar ratio to biological apatite the lack of ionic substitution makes the property of the synthetic apatite different to the biological apatite.…”

Section: Introductionmentioning

confidence: 85%

Hydoxyapatite/beta‐tricalcium phosphate biphasic ceramics as regenerative material for the repair of complex bone defects

2017

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Bone is a composite material composed of collagen and calcium phosphate (CaP) mineral. The collagen gives bone its flexibility while the inorganic material gives bone its resilience. The CaP in bone is similar in composition and structure to the mineral hydroxyapatite (HA) and is bioactive, osteoinductive and osteoconductive. Therefore synthetic versions of bone apatite (BA) have been developed to address the demand for autologous bone graft substitutes. Synthetic HA (s-HA) are stiff and strong, but brittle. These lack of physical attributes limit the use of synthetic apatites in situations where no physical loading of the apatite occurs. s-HA chemical properties differ from BA and thus change the physical and mechanical properties of the material. Consequently, s-HA is more chemically stable than BA and thus its resorption rate is slower than the rate of bone regeneration. One solution to this problem is to introduce a faster resorbing CaP, such as β-tricalcium phosphate (β-TCP), when synthesizing the material creating a biphasic (s-HA and β-TCP) formulation of calcium phosphate (BCP). The focus of this review is to introduce the major differences between BCP and biological apatites and how material scientists have overcome the inadequacies of the synthetic counterparts. Examples of BCP performance in vitro and in vivo following structural and chemical modifications are provided as well as novel ultrastructural data. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2493-2512, 2018.

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Section: Introductionmentioning

confidence: 85%

Hydoxyapatite/beta‐tricalcium phosphate biphasic ceramics as regenerative material for the repair of complex bone defects

2017

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“…In addition to calcium, many other ions such as magnesium, silicon, zinc, potassium and copper play important roles in bone regeneration, from regulating the metabolic processes and osteoblastic differentiation genes to promoting angiogenesis and increasing bone cell adhesion [17,18] . With regards to bone formation and dissolution, magnesium has been shown to play a major role in calcification and bone density, mineral metabolism, hydroxyapatite crystal formation and increased bone cell adhesion and stability [16,[19][20][21] . Phosphate is not only a main component of bone growth, but has also been shown to stimulate expression of matrix gla protein which is involved in bone formation [17] .…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Systematic Assessment of Synthesized Tri-magnesium Phosphate Powders (Amorphous, Semi-crystalline and Crystalline) and Cements for Ceramic Bone Cement Applications

Ostrowski

Sharma

Roy

et al. 2015

Journal of Materials Science & Technology

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“…After subcutaneous implantation in rats, it remained mechanically and chemically stable for several months when cellular contact was prevented and extracellular fluid provided. 36 Even though osteoclasts resorb CDA type CPBCs 37 and some macrophages were degrading the cement (Fig. 13), the implant was only slightly degraded after 3 weeks (Fig.…”

Section: Discussionmentioning

confidence: 97%

In vitro characterization and in vivo properties of a carbonated apatite bone cement

Khaϊroun

Magne

Gauthier

et al. 2002

J. Biomed. Mater. Res.

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This study evaluated the in vivo behavior of an injectable calcium phosphate bone cement implanted in bone defects at the distal end of rabbit femora. After 3 weeks, samples were harvested and processed for undecalcified sectioning. Scanning electron microscopy, transmission electron microscopy, and Fourier transform infrared microspectroscopy showed direct contact of bone and cement without soft tissue interposition, biocompatibility, and bioactivity with osteoconductive properties.

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In vivo behaviour of three calcium phosphate cements and a magnesium phosphate cement

Cited by 48 publications

References 28 publications

Hydoxyapatite/beta‐tricalcium phosphate biphasic ceramics as regenerative material for the repair of complex bone defects

Hydoxyapatite/beta‐tricalcium phosphate biphasic ceramics as regenerative material for the repair of complex bone defects

Systematic Assessment of Synthesized Tri-magnesium Phosphate Powders (Amorphous, Semi-crystalline and Crystalline) and Cements for Ceramic Bone Cement Applications

In vitro characterization and in vivo properties of a carbonated apatite bone cement

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