In vivo assessment of subretinally implanted microphotodiode arrays in cats by optical coherence tomography and fluorescein angiography

Abstract

OCT and FA have been fruitfully applied to cats to assess the morphological and circulatory conditions of the neuroretina and of its interface with the subretinal implant. The techniques may therefore provide a tool for objective, noninvasive in vivo evaluation of eyes that have undergone subretinal implant surgery, both in research animals and in humans.

Compound subretinal prostheses with extra-ocular parts designed for human trials: successful long-term implantation in pigs

“…Optical coherence tomography (OCT) was performed in the standard manner in series 1, as described by Volker and colleagues [36]. In this study a Stratus Optical Coherence Tomograph Model 3000 (Carl Zeiss Meditec, Dublin, CA, USA; software version 4.0.1) was used.…”

A review of in vivo animal studies in retinal prosthesis research

“…Lensectomy and subsequent air injection into the anterior chamber have been reported to provide excellent visualisation of the posterior segment and to allow a more anterior access for instrument insertion through the corneal incisions [43]. Because of the high reflectivity of the tapetum lucidum no endoillumination is necessary, making two-port vitrectomy possible [114]. It may not be necessary to perform the hazardous step of posterior hyaloid face detachment in order to obtain a posterior vitreous detachment [114].…”

“…Because of the high reflectivity of the tapetum lucidum no endoillumination is necessary, making two-port vitrectomy possible [114]. It may not be necessary to perform the hazardous step of posterior hyaloid face detachment in order to obtain a posterior vitreous detachment [114]. As in the rat, subretinal viscoelastics have been used to obtain a subretinal bleb through which to insert an implant [114].…”

“…It may not be necessary to perform the hazardous step of posterior hyaloid face detachment in order to obtain a posterior vitreous detachment [114]. As in the rat, subretinal viscoelastics have been used to obtain a subretinal bleb through which to insert an implant [114]. Epiretinal device fixation using a retinal tack is thought to be unsafe in the cat, given the marked thinning of the posterior sclera [43].…”

“…We identified 18 studies. The cat model has been used to test the feasibility [18, 21-23, 93, 117], biocompatibility [18,19,79,82,101,114] and functioning of specific devices or electrodes [18, 19, 21-23, 30, 32, 43, 78, 82, 93, 98, 99, 101, 117, 120]. Because of the wellestablished cortical recording techniques and the good understanding of the feline visual system, this model has been largely used in testing cortical representation of electrical retinal stimulation with cortical electrode recordings [18, 19, 21-23, 30, 32, 43, 58, 79, 82, 93, 98, 99, 114, 117, 120, 101]( Table 2).…”