In Vivo Assessment of Ovarian Tumor Response to Tyrosine Kinase Inhibitor Pazopanib by Using Hyperpolarized<sup>13</sup>C-Pyruvate MR Spectroscopy and<sup>18</sup>F-FDG PET/CT Imaging in a Mouse Model

Ravoori, Murali; Singh, Shailbala; Lee, Jae-Hyuk; Bankson, James A.; Kundra, Vikas

doi:10.1148/radiol.2017161772

Cited by 28 publications

(51 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Significant correlations between pyruvate-to-lactate rate constants and 18 F-FDG uptake were found for sarcoma patients, whereas no significant correlations appeared for carcinoma patients. The sarcoma patients showed a non-significant trend towards lower 18 F-FDG uptake and higher lactate generation than carcinoma patients. However, the ratio of lactate generation to 18 F-FDG uptake was found to be significantly higher in sarcoma as compared to carcinoma.…”

mentioning

confidence: 70%

“…The sarcoma patients showed a non-significant trend towards lower 18 F-FDG uptake and higher lactate generation than carcinoma patients. However, the ratio of lactate generation to 18 F-FDG uptake was found to be significantly higher in sarcoma as compared to carcinoma. The results were found both when lactate generation was estimated as an apparent pyruvate-to-lactate rate constant from dynamic 13 C MRS and as an [1][2][3][4][5][6][7][8][9][10][11][12][13] C]lactate to total 13 C ratio from 13 …”

mentioning

confidence: 78%

“…Here, we aim to compare hyperpolarized [1-13 C]pyruvate MRS with simultaneous 18 F-2-fluoro-2-deoxy-D-glucose (FDG) PET in a cross-sectional study of canine cancer patients. Methods: Canine cancer patients underwent integrated PET/MRI using a clinical whole-body system.…”

mentioning

confidence: 99%

“…Hyperpolarized [1-13 C]pyruvate was obtained using dissolution-DNP. 18 F-FDG PET, dynamic 13 C MRS, 13 C MRS Imaging (MRSI) and anatomical 1 H MRI was acquired from 17 patients. Apparent pyruvate-to-lactate rate constants were estimated from dynamic 13 C MRS. 18 F-FDG Standard Uptake Values and maximum [1- 13 C]lactate-to-total- 13 C ratios were obtained from tumor regions of interest.…”

mentioning

confidence: 99%

“…Apparent pyruvate-to-lactate rate constants were estimated from dynamic 13 C MRS. 18 F-FDG Standard Uptake Values and maximum [1- 13 C]lactate-to-total- 13 C ratios were obtained from tumor regions of interest. Following inspection of data, patients were grouped according to main cancer type and linear regression between measures of lactate generation and 18 F-FDG uptake were tested within groups. Between groups, the same measures were tested for group differences.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Combined hyperpolarized 13C-pyruvate MRS and 18F-FDG PET (hyperPET) estimates of glycolysis in canine cancer patients

Hansen

Gutte

Holst

et al. 2018

European Journal of Radiology

View full text Add to dashboard Cite

A B S T R A C TF-FDG uptake were tested within groups. Between groups, the same measures were tested for group differences.Results: The main cancer types of the 17 patients were sarcoma (n = 11), carcinoma (n = 5) and mastocytoma (n = 1). Significant correlations between pyruvate-to-lactate rate constants and 18 F-FDG uptake were found for sarcoma patients, whereas no significant correlations appeared for carcinoma patients. The sarcoma patients showed a non-significant trend towards lower 18 F-FDG uptake and higher lactate generation than carcinoma patients. However, the ratio of lactate generation to 18 F-FDG uptake was found to be significantly higher in sarcoma as compared to carcinoma. The results were found both when lactate generation was estimated as an apparent pyruvate-to-lactate rate constant from dynamic 13 C MRS and as an [1-13 C]lactate to total 13 C ratio from 13 C MRSI. This finding could be important for the interpretation and eventual clinical implementation of hyperpolarized 13 C. In addition, the differences between the two modalities may allow for better metabolic phenotyping performing hybrid imaging in the form of hyperPET. Conclusions

show abstract

mentioning

confidence: 70%

mentioning

confidence: 78%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Combined hyperpolarized 13C-pyruvate MRS and 18F-FDG PET (hyperPET) estimates of glycolysis in canine cancer patients

Hansen

Gutte

Holst

et al. 2018

European Journal of Radiology

View full text Add to dashboard Cite

show abstract

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Antwi-Baah

Wang

Chen

et al. 2022

Adv Materials Inter

View full text Add to dashboard Cite

Over the years, several imaging techniques have been developed to improve alreadyexisting ones, thus, overcoming the obstacles that previous ones failed to overcome. Recently, much energy has been put into developing tools that complement the ability of the current imaging techniques. Imaging probe or contrast agent is one of the well-known tools in this category, which enhance the conspicuousness of images. Researchers have taken the opportunity to work tirelessly on developing imaging probes, which have gone a long way in attaining biological and functional image details of a biological system when used alongside existing imaging techniques. With the advantage of displaying a more detailed view for analyzing biological information and diagnosing diseases, imaging probes are undoubtedly a significant research field in biological and medical sciences.Molecular imaging, a term describing the visualization of specific molecules and molecular transformations that occur during disease activity in a living system using radiological and nuclear medicine, [2] has recently received enormous attention. A tissue or organ is diseased when it depicts characteristics that deviate from its normal functionality or organization. The diseased condition is stimulated by many biochemical processes involving internal and external stimuli from within the cell. Molecular imaging serves as a diagnostic tool for detecting abnormal disease molecules early because it can examine the biochemical adjustments as a normal tissue mutates into a diseased one. Representative imaging techniques include magnetic particle imaging (MPI), [3] positron emission tomography (PET), single-photon emission computed tomography (SPECT), optical imaging, magnetic resonance imaging (MRI), computed tomography (CT) and, ultrasound. [4] These imaging techniques are noninvasive diagnostic platforms that bridge the gap between molecular biology and molecular medicine. They allow examining a living organism to verify effects on multiple organ systems in vivo and help diagnose diseases at preclinical stages. These imaging techniques employ tracers or contrast agents to improve sensitivity. MPI is a tracer imaging modality that instantaneously quantifies the concentration and Metal-based nanoparticles, especially gadolinium, manganese, and iron, have gained ground in the research of magnetic resonance imaging (MRI) contrast agents. Over the years, contrast agents based on these paramagnetic and superparamagnetic nanomaterials have merited keen attention in the biomedical field due to their desired properties such as sizeable magnetic susceptibility, tunable size, easy surface functionalization, low toxicity, etc. Gadolinium-based chelates are the traditional MRI contrast agents in the clinic but require improved relaxivities and pharmacokinetics. Nanoparticles possess a larger surface area, demonstrate a longer retention time in the body, and allow the conjugation of several functional molecules to enhance tumor targeting, making them more advantageous. The pursuit o...

show abstract

Cancer metabolism in a snapshot: MRS(I)

2019

View full text Add to dashboard Cite

The contribution of MRS(I) to the in vivo evaluation of cancer-metabolism-derived metrics, mostly since 2016, is reviewed here. Increased carbon consumption by tumour cells, which are highly glycolytic, is now being sampled by 13 C magnetic resonance spectroscopic imaging (MRSI) following the injection of hyperpolarized [1-13 C] pyruvate (Pyr). Hot-spots of, mostly, increased lactate dehydrogenase activity or flow between Pyr and lactate (Lac) have been seen with cancer progression in prostate (preclinical and in humans), brain and pancreas (both preclinical) tumours. Therapy response is usually signalled by decreased Lac/Pyr 13 C-labelled ratio with respect to untreated or nonresponding tumour. For therapeutic agents inducing tumour hypoxia, the 13 C-labelled Lac/bicarbonate ratio may be a better metric than the Lac/Pyr ratio. 31 P MRSI may sample intracellular pH changes from brain tumours (acidification upon antiangiogenic treatment, basification at fast proliferation and relapse). The steady state tumour metabolome pattern is still in use for cancer evaluation. Metrics used for this range from quantification of single oncometabolites (such as 2-hydroxyglutarate in mutant IDH1 glial brain tumours) to selected metabolite ratios (such as total choline to N-acetylaspartate (plain ratio or CNI index)) or the whole 1 H MRSI(I) pattern through pattern recognition analysis. These approaches have been applied to address different questions such as tumour subtype definition, following/predicting the response to therapy or defining better resection or radiosurgery limits. KEYWORDSanimal model study, cancer, cellular and molecular cancer imaging, hyperpolarized C-13, MRS and MRSI methods, phosphorus MRS/MRSI | TEMPORAL AND THEMATIC BOUNDARIES OF THE TOPICS COVEREDThe authors of this review declare at the outset that there is no intention of being exhaustive or systematic. The temporal boundaries reviewed will be modest: only relevant literature since 2016, chosen according to our bias. Earlier work or reviews will only be referred to in order to put recent findings in due perspective. Authors hope that this summary will give readers a picture of how far cancer metabolism analysis with MRS(I) has advanced and, perhaps, why it is not advancing further.For quite a long time MRS, rather than MRI, has been the only approach able to evaluate cancer metabolism. Nevertheless, the MRI-derived information related to cancer metabolism should not be forgotten: consider for example the chemical exchange saturation transfer (CEST) effect caused by exchangeable protons in water-derived images of glucose uptake and metabolism in tumours. 1,2 However, apart from these CESTrelated studies, we should acknowledge that most information about cancer metabolism using MR still refers to MRS(I) acquisitions, which are the ones dealt with in our text.Supplementary Figure 1 shows a PUBMED search illustrating the different proportions of articles investigating several cancer types through MRS(I) approaches. The retrieved information can help unders...

show abstract

In Vivo Assessment of Ovarian Tumor Response to Tyrosine Kinase Inhibitor Pazopanib by Using Hyperpolarized¹³C-Pyruvate MR Spectroscopy and¹⁸F-FDG PET/CT Imaging in a Mouse Model

Cited by 28 publications

References 35 publications

Combined hyperpolarized 13C-pyruvate MRS and 18F-FDG PET (hyperPET) estimates of glycolysis in canine cancer patients

Combined hyperpolarized 13C-pyruvate MRS and 18F-FDG PET (hyperPET) estimates of glycolysis in canine cancer patients

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Cancer metabolism in a snapshot: MRS(I)

Contact Info

Product

Resources

About

In Vivo Assessment of Ovarian Tumor Response to Tyrosine Kinase Inhibitor Pazopanib by Using Hyperpolarized13C-Pyruvate MR Spectroscopy and18F-FDG PET/CT Imaging in a Mouse Model

Cited by 28 publications

References 35 publications

Combined hyperpolarized 13C-pyruvate MRS and 18F-FDG PET (hyperPET) estimates of glycolysis in canine cancer patients

Combined hyperpolarized 13C-pyruvate MRS and 18F-FDG PET (hyperPET) estimates of glycolysis in canine cancer patients

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Cancer metabolism in a snapshot: MRS(I)

Contact Info

Product

Resources

About

In Vivo Assessment of Ovarian Tumor Response to Tyrosine Kinase Inhibitor Pazopanib by Using Hyperpolarized¹³C-Pyruvate MR Spectroscopy and¹⁸F-FDG PET/CT Imaging in a Mouse Model