In vivo assessment of hepatotoxicity, nephrotoxicity and biodistribution using 3-aminopropyltriethoxysilane-coated magnetic nanoparticles (APTS-MNPs) in ICR mice

Wang, Xiaowen; Zhang, Jieying; Yang, Xin; Tang, Zhenghai; Yan-wen, HU; Chen, Benke; Tang, Jintian

doi:10.1007/s11434-014-0296-4

Cited by 9 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, these NPs (e.g., Fe and Zn ENPs) reached higher accumulation concentrations, but with less reproductive toxicity, as shown in Figures a and b. Such inconsistency between the accumulation concentration and reproductive toxicity of ENPs deserves attention in the assessment and control of nanotoxicity. , Figure b shows that i.p. injection posed a significantly higher risk of ENP accumulation in the testes than other exposure pathways ( p 1 , p 2 < 0.0001), probably because i.p.…”

Section: Results and Discussionmentioning

confidence: 87%

“…Such inconsistency between the accumulation concentration and reproductive toxicity of ENPs deserves attention in the assessment and control of nanotoxicity. 50,51 Figure 5b shows that i.p. injection posed a significantly higher risk of ENP accumulation in the testes than other exposure pathways (p 1 , p 2 < 0.0001), probably because i.p.…”

Section: Environmental Science and Technologymentioning

confidence: 99%

See 1 more Smart Citation

Screening Priority Factors Determining and Predicting the Reproductive Toxicity of Various Nanoparticles

Ban

Zhou

Sun

et al. 2018

Environ. Sci. Technol.

View full text Add to dashboard Cite

Due to the numerous factors (e.g., nanoparticle [NP] properties and experimental conditions) influencing nanotoxicity, it is difficult to identify the priority factors dominating nanotoxicity. Herein, by integrating data from the literature and a random forest model, the priority factors determining reproductive toxicity were successfully screened from highly heterogeneous data. Among 10 factors from more than 18 different NPs, the NP type and the exposure pathway were found to dominantly determine NP accumulation. The reproductive toxicity of various NPs primarily depended on the NP type and the toxicity indicators. Nanoparticles containing major elements (e.g., Zn and Fe) tended to accumulate in rats but induced lower toxicity than NPs containing noble elements. Compared with other exposure pathways, i.p. injection posed significantly higher risks for NP accumulation. By combining similarity network analysis and hierarchical clustering, the sources of highly heterogeneous data were identified, the factor-toxicity dependencies were extracted and visualized, and the prediction of nanotoxicity was then achieved based on the screened priority factors. The present work provides insights for the design of animal experiments and the illustration and prediction of nanotoxicity.

show abstract

Section: Results and Discussionmentioning

confidence: 87%

Section: Environmental Science and Technologymentioning

confidence: 99%

Screening Priority Factors Determining and Predicting the Reproductive Toxicity of Various Nanoparticles

Ban

Zhou

Sun

et al. 2018

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…The research group hence suggested a long time study to assess the toxicity risks [ 106 ]. In a further study, intraperitoneal injection with 3-aminopropyl-triethoxysilane-coated magnetic nanoparticles (APTS-MNPs) into ICR mice showed the biodistribution of iron in various body tissues to change with time (analyzed at 1, 2, 3 and 4 weeks), where a greater fraction of iron was localized in the liver and spleen, not causing continuing changes in liver and kidney function with time and hence it was concluded they were safe for in vivo application usage, although the concluding remarks of the study suggested the work to be inadequate and suggested more investigations be done at a molecular level [ 107 ]. The binding of MNPs to exogenous structures may cause different responses and influence their uptake and metabolism depending on the organ or cell type [ 108 ].…”

Section: Mnp Metabolism and Toxicitymentioning

confidence: 99%

Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review

et al. 2020

View full text Add to dashboard Cite

The noteworthy intensification in the development of nanotechnology has led to the development of various types of nanoparticles. The diverse applications of these nanoparticles make them desirable candidate for areas such as drug delivery, coasmetics, medicine, electronics, and contrast agents for magnetic resonance imaging (MRI) and so on. Iron oxide magnetic nanoparticles are a branch of nanoparticles which is specifically being considered as a contrast agent for MRI as well as targeted drug delivery vehicles, angiogenic therapy and chemotherapy as small size gives them advantage to travel intravascular or intracavity actively for drug delivery. Besides the mentioned advantages, the toxicity of the iron oxide magnetic nanoparticles is still less explored. For in vivo applications magnetic nanoparticles should be nontoxic and compatible with the body fluids. These particles tend to degrade in the body hence there is a need to understand the toxicity of the particles as whole and degraded products interacting within the body. Some nanoparticles have demonstrated toxic effects such inflammation, ulceration, and decreases in growth rate, decline in viability and triggering of neurobehavioral alterations in plants and cell lines as well as in animal models. The cause of nanoparticles’ toxicity is attributed to their specific characteristics of great surface to volume ratio, chemical composition, size, and dosage, retention in body, immunogenicity, organ specific toxicity, breakdown and elimination from the body. In the current review paper, we aim to sum up the current knowledge on the toxic effects of different magnetic nanoparticles on cell lines, marine organisms and rodents. We believe that the comprehensive data can provide significant study parameters and recent developments in the field. Thereafter, collecting profound knowledge on the background of the subject matter, will contribute to drive research in this field in a new sustainable direction.

show abstract

“…Recently, multifunctional nanoparticles combining the advantages of two or more different materials in a single system have demonstrated promising prospects in biomedical applications, such as cell separation [1][2][3], molecular imaging [4][5][6][7][8], and drug delivery [9][10][11][12][13]. Among the variety of multifunctional systems, nanoplatforms that incorporate targeting, diagnostic, and therapeutic agents together represent a new paradigm in nanomedicine [14][15][16][17][18], which would make cancer theranostics possible.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes

Lin

Jin

et al. 2015

Science Bulletin

View full text Add to dashboard Cite

In vivo assessment of hepatotoxicity, nephrotoxicity and biodistribution using 3-aminopropyltriethoxysilane-coated magnetic nanoparticles (APTS-MNPs) in ICR mice

Cited by 9 publications

References 28 publications

Screening Priority Factors Determining and Predicting the Reproductive Toxicity of Various Nanoparticles

Screening Priority Factors Determining and Predicting the Reproductive Toxicity of Various Nanoparticles

Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review

Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes

Contact Info

Product

Resources

About