In Vivo Assessment of Corneal Endothelial Function in Diabetes Mellitus

Saini, Jagjit S.; Mittal, Sakshi

doi:10.1001/archopht.1996.01100130641001

Cited by 64 publications

(36 citation statements)

References 10 publications

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“…In eyes with diabetes mellitus, morphologic abnormalities and a delay in the resolution of postoperative corneal edema have been reported. [24][25][26] In a study by Lee et al, 27 patients with diabetes had an increased central corneal thickness and coefficient of variation and a decreased ECD and percentage of hexagonal cells than healthy controls after cataract surgery. The results in the present study suggest that in diabetic patients, corneal endothelial cells are susceptible to damage and careful attention must be paid in deciding the timing of the surgery and during cataract surgery, especially in cases with a low ECD.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of cataract surgery in eyes with a low corneal endothelial cell density

Yamazoe¹,

Yamaguchi²,

Hotta³

et al. 2011

Journal of Cataract and Refractive Surgery

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Section: Discussionmentioning

confidence: 99%

Outcomes of cataract surgery in eyes with a low corneal endothelial cell density

Yamazoe¹,

Yamaguchi²,

Hotta³

et al. 2011

Journal of Cataract and Refractive Surgery

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“…Saini and Mittal [12]in their study observed significantly lower corneal endothelial function in diabetics and suggested its higher possibility to decompensate if stressed.…”

Section: Discussionmentioning

confidence: 99%

“…However some authors claim that not all diabetic patients may be at risk in intraocular surgery [8, 9]. In previous reports there are conflicting results concerning functional abnormalities [10, 11, 12, 13, 14, 15, 16]and cell density [10, 11, 17, 18, 19, 20, 21], but all of the authors agree on significant morphological abnormalities of the diabetic cornea.…”

Section: Introductionmentioning

confidence: 99%

Corneal Endothelium Evaluation in Type I and Type II Diabetes mellitus

Roszkowska¹,

Tringali²,

Colosi³

et al. 1999

Ophthalmologica

108

116

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Background: The purpose of this study is to evaluate the corneal endothelium in type I and type II diabetic patients. Methods: Seventy-five diabetics divided into type I and type II groups and 62 healthy volunteers took part in the study. The mean endothelial cell density and morphology, and the central corneal thickness were evaluated and statistical analysis was done. Results: All evaluated parameters were found to be significantly different in both diabetic groups with reduction of the mean cell density of 5% in type II and of 11% in type I diabetes with respect to the normal age-matched control group. Important alterations of endothelial morphology were observed. The central corneal pachymetry was significantly higher in diabetics, with p < 0.01 in the type I group and p < 0.05 in the type II group. Conclusion: It is concluded that corneal endothelium in diabetices should still be considered as a tissue under continuous metabolic stress with consequent high vulnerability, especially in case of any external insult such as a surgical procedure.

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“…8,9,12 In addition, although corneal edema inducedbycontactlenswearissimilarindiabetic and nondiabetic groups, corneal edema recovery is slower in patients with diabetes mellitusthanincontrolsubjects. 13,14 Thissuggests that the cornea in patients with diabetes mellitus is weaker than the normal cornea against physical stress. In contrast, Weston et al 15 reported that induced swelling was less in patients with diabetes mellitus than in controls, and the corneal deswelling rate was not different between diabetic and control subjects.…”

mentioning

confidence: 98%

Corneal Changes After Small-Incision Cataract Surgery in Patients WithDiabetes Mellitus

Morikubo

Takamura²,

Kubo³

et al. 2004

Arch Ophthalmol

100

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To evaluate functional impairment in the corneal endothelium of eyes in patients with diabetes mellitus, after small-incision cataract surgery.Methods: Evaluation was performed in 93 eyes in patients with type 2 diabetes mellitus (diabetic group) and 93 eyes in patients without diabetic mellitus (nondiabetic group) who underwent cataract surgery. Using a topography system, the corneal thickness in the central area was measured before surgery and 1 day, 1 week, and 1 month after surgery. Corneal endothelial cells were counted using a noncontact specular microscope.Results: No significant differences in any preoperative measures were observed between the diabetic and non-diabetic groups. The increase in corneal thickness 1 month after surgery was significantly higher in the diabetic group than in the nondiabetic group (P=.03). The corneal endothelial cell losses 1 day and 1 week after surgery were significantly higher in the diabetic group than in the nondiabetic group (after 1 day, P = .03; and after 1 week, P =.04). Conclusion:Compared with nondiabetic eyes, eyes of patients with diabetes mellitus showed more damage in corneal endothelial cells due to cataract surgery and a delay in the postoperative recovery of corneal edema.

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In Vivo Assessment of Corneal Endothelial Function in Diabetes Mellitus

Cited by 64 publications

References 10 publications

Outcomes of cataract surgery in eyes with a low corneal endothelial cell density

Outcomes of cataract surgery in eyes with a low corneal endothelial cell density

Corneal Endothelium Evaluation in Type I and Type II Diabetes mellitus

Corneal Changes After Small-Incision Cataract Surgery in Patients WithDiabetes Mellitus

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