In vivo assessment of antidiabetic and antioxidant activities of methanol extract of Smilax zeylanica leaves in wistar rats

Phytochemical and Antinociceptive, Anti‐Inflammatory, and Antioxidant Studies of Smilax larvata (Smilacaceae)

“…The qualitative phytochemical screening results are in agreement with previous works on Smilax species [2]. After chromatographic purification processes we identified three flavonoids, ( 1 ) drabanemoroside, ( 2 ) kaempferol 3- O - α -L-rhamnopyranosyl(1→2)- α -L-rhamnopyranoside, and ( 3 ) kaempferol, and two phenolic compounds, ( 4 ) p -hydroxybenzoic acid and ( 5 ) p- coumaric acid, in EtOAc [30–34].…”

“…The antioxidant activity of the EtOAc extract can be due to the presence of phenolic compounds, which presents antioxidant activity by donating hydrogen atoms or electrons and thereby scavenges free radicals [22]. These findings are in accordance with the total phenolic content, which showed a low amount of these compounds in S. larvata extracts, comparing with other Smilax species [2]. However, CHCl 3 , SLG, and n -hexane extracts significantly reduced the lipid peroxidation.…”

“…The genus Smilax belongs to the Smilacaceae family and comprises about 350 species of herbaceous plants, climbing and vines, also described as shrubs with creeping high branches [1, 2]. Distributed in tropical and subtropical regions, Smilax species are extensively used in traditional medicine around the world and in Brazil for the treatment of rheumatism and syphilis and as a diuretic [3, 4].…”

“…In this way, compounds with anti-inflammatory as well as antioxidant and antiarthritic activities were isolated from this genus, among them Smilaxchinoside A–D, Sieboldogenin, and Astilbin [9–11]. Phytochemical studies revealed the presence of saponins, flavonoids, phenolic compounds, tannins, alkaloids, and phenylpropanoids glucosides [2, 6, 7, 12]. …”

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“…The lowering of LDH and creatinine in serum of EPF treated rats is presumed mainly to be a manifestation of lowering of blood glucose level. The increase in the levels of lipid peroxidation indicates a decrease in the enzymatic antioxidant defence mechanism 22 . Several studies showed that oxygen free radicals are generated in diabetic state, and reduction in the activity of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) also contributes to the development of oxidative stress in DM [23][24] .…”