In vivo articular cartilage regeneration through infrapatellar adipose tissue derived stem cell in nanofiber polycaprolactone scaffold

Vahedi, Parviz; Jarolmasjed, Seyedhosein; Shafaei, Hajar; Roshangar, Leila; Rad, Jafar Soleimani; Ahmadian, Elham

doi:10.1016/j.tice.2019.02.002

Cited by 24 publications

(9 citation statements)

References 33 publications

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“…Numerous studies report that allogenic/xenogeneic MSCs promote osteochondral regeneration in ruminants. Allogenic bMSCs or aMSCs seeded onto polycaprolactone, collagen, alginate, and/or tantalum scaffolds improve cartilaginous tissue deposition and histologic scores compared to untreated defects in sheep (Vahedi et al, 2019;Favreau et al, 2020) and goats (Wei et al, 2019), with comparable histological scoring to autograft reported (Keller et al, 2019). Injection of aMSCs in sheep similarly suppressed synovial fluid inflammatory factors and bolstered histological, macroscopic, and MRI scores (Feng et al, 2018;Lv et al, 2018;Veronesi et al, 2022).…”

Section: Ruminant Modelsmentioning

confidence: 97%

Updates on mesenchymal stem cell therapies for articular cartilage regeneration in large animal models

Liu

Xiao

et al. 2022

Front. Cell Dev. Biol.

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There is an unmet need for novel and efficacious therapeutics for regenerating injured articular cartilage in progressive osteoarthritis (OA) and/or trauma. Mesenchymal stem cells (MSCs) are particularly promising for their chondrogenic differentiation, local healing environment modulation, and tissue- and organism-specific activity; however, despite early in vivo success, MSCs require further investigation in highly-translatable models prior to disseminated clinical usage. Large animal models, such as canine, porcine, ruminant, and equine models, are particularly valuable for studying allogenic and xenogenic human MSCs in a human-like osteochondral microenvironment, and thus play a critical role in identifying promising approaches for subsequent clinical investigation. In this mini-review, we focus on [1] considerations for MSC-harnessing studies in each large animal model, [2] source tissues and organisms of MSCs for large animal studies, and [3] tissue engineering strategies for optimizing MSC-based cartilage regeneration in large animal models, with a focus on research published within the last 5 years. We also highlight the dearth of standard assessments and protocols regarding several crucial aspects of MSC-harnessing cartilage regeneration in large animal models, and call for further research to maximize the translatability of future MSC findings.

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Section: Ruminant Modelsmentioning

confidence: 97%

Updates on mesenchymal stem cell therapies for articular cartilage regeneration in large animal models

Liu

Xiao

et al. 2022

Front. Cell Dev. Biol.

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“…Hence, tissue engineering of cartilage has found its potential to regenerate the cartilage tissue. [167][168][169][170][171] Fabrication of scaffold with proper mechanical properties is a challenging task in tissue engineering application. Zadehnajar et al electrospun PCL/gelatin nanofibers loaded with multiwalled carbon nanotubes (MWCNTs).…”

Section: Cartilage Tissue Engineeringmentioning

confidence: 99%

Sustainable nanofibers in tissue engineering and biomedical applications

Malik

Sundarrajan

Hussain

et al. 2020

Mat Design & Process Comms

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The practice of using a massive amount of environmental unfriendly and toxic petroleum-based materials in tissue engineering and biomedical fields demands the materials, which are biodegradable, renewable, environmentally friendly, biocompatible, and bioactive. So, renewable polymers have got considerable attention due to their numerous desirable properties. The nanofibers that are prepared from renewable materials and their blends can integrate the properties of both nanofibers and renewable polymers. Development of scaffolds that mimic the construction of tissues at nanoscale is a great challenge for tissue engineering. Electrospinning is the most promising technique for nanofibers formation. Nanofibers provide a platform for cell adhesion, proliferation, and differentiation. Therefore, nanofibers from sustainable materials have been used in tissue engineering and biomedical fields. In this review, methods for nanofibers fabrication, sustainable nanofibers made from natural and synthetic polymers and their applications in tissue engineering and biomedical field, have been emphasized.

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“…Although some animals regrow complete body parts subsequent an injury, human being lack this specificity. Regenerative medicine has opened a new avenue regarding this issue [42,43]. The utility of redox-initiated HA hydrogel in the repair of the cardiac tissue has been studied.…”

Section: Tissue Repairmentioning

confidence: 99%

The Potential Applications of Hyaluronic Acid Hydrogels in Biomedicine

et al. 2019

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Hyaluronic acid (HA) is widely used in the biomedicine due to its biocompatibility, biodegradability, and nontoxic properties. It is crucial for cell signaling role during morphogenesis, inflammation, and wound repair. After hydrogel formation, HA easily is converted to elastic sheets in order to use in preclinical and clinical applications. In addition, HA-derived hydrogels are easily used as vectors for cell and medication in tissue repairing and regenerative medicine. Moreover, in comparison with other polymers, HA -based hydrogels play a key role in in cellular behavior, including stem cell differentiation. The current paper reviews both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications.

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In vivo articular cartilage regeneration through infrapatellar adipose tissue derived stem cell in nanofiber polycaprolactone scaffold

Cited by 24 publications

References 33 publications

Updates on mesenchymal stem cell therapies for articular cartilage regeneration in large animal models

Updates on mesenchymal stem cell therapies for articular cartilage regeneration in large animal models

Sustainable nanofibers in tissue engineering and biomedical applications

The Potential Applications of Hyaluronic Acid Hydrogels in Biomedicine

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