In vivo articular cartilage deformation: noninvasive quantification of intratissue strain during joint contact in the human knee

Chan, Deva D.; Cai, Luyao; Butz, Kent D.; Trippel, Stephen B.; Nauman, Eric A.; Neu, Corey P.

doi:10.1038/srep19220

Cited by 122 publications

(127 citation statements)

References 55 publications

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“…, within individual cartilage zones. Displacements of chondrocytes in cartilage sections have been mapped via digital image correlation [5,6,15], or through the use of displacement-encoded magnetic resonance imaging [16,17]; however, these methods apply loads to bulk sections of tissue and prevents direct loading of specific cartilage zones. Thus, while inverse methods have been applied to estimate properties, the quantification of time-dependent mechanisms remains daunting and prone to error.…”

Section: Introductionmentioning

confidence: 99%

Indentation mapping revealed poroelastic, but not viscoelastic, properties spanning native zonal articular cartilage

et al. 2017

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Osteoarthrosis is a debilitating disease affecting millions, yet engineering materials for cartilage regeneration has proven difficult because of the complex microstructure of this tissue. Articular cartilage, like many biological tissues, produces a time-dependent response to mechanical load that is critical to cell’s physiological function in part due to solid and fluid phase interactions and property variations across multiple length scales. Recreating the time-dependent strain and fluid flow may be critical for successfully engineering replacement tissues but thus far has largely been neglected. Here, microindentation is used to accomplish three objectives: (1) quantify a materials time-dependent mechanical response, (2) map material properties at a cellular relevant length scale throughout zonal articular cartilage, (3) and elucidate the underlying viscoelastic, poroelastic, and nonlinear poroelastic causes of deformation in articular cartilage. Untreated and trypsin-treated cartilage were sectioned perpendicular to the articular surface and indentation was used to evaluate properties throughout zonal cartilage on the cut surface. The experimental results demonstrated that within all cartilage zones, the mechanical response was well represented by a model assuming nonlinear biphasic behavior and did not follow conventional viscoelastic or linear poroelastic models. Additionally, 10% (w/w) agarose was tested and, as anticipated, behaved as a linear poroelastic material. The approach outlined here provides a method, applicable to many tissues and biomaterials, which reveals and quantifies the underlying causes of time-dependent deformation, elucidates key aspects of material structure and function, and that can be used to provide important inputs for computational models and targets for tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Indentation mapping revealed poroelastic, but not viscoelastic, properties spanning native zonal articular cartilage

et al. 2017

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“…Numerous studies have investigated the tibiofemoral cartilage contact using both in-vitro and in-vivo experimental set ups, including cadaveric knee tests (D'Agata et al, 1993; Guettler et al, 2005), in silico three dimensional (3D) knee joint modeling (Halonen et al, 2014; Shim et al, 2016), in-vivo imaging measurements (Bingham et al, 2008; Carter et al, 2015; Chan et al, 2016; Coleman et al, 2013; Eckstein et al, 2005; Henak et al, 2013; Kaiser et al, 2016; Lad et al, 2016; Liu et al, 2010; Sutter et al, 2015). While these studies have greatly advanced our knowledge on human knee joint biomechanics, no data has been reported on the articular surface geometry at the contact locations.…”

Section: Introductionmentioning

confidence: 99%

Analysis of in-vivo articular cartilage contact surface of the knee during a step-up motion

Yin¹,

Kernkamp

et al. 2017

Clinical Biomechanics

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Background Numerous studies have reported on the tibiofemoral articular cartilage contact kinematics, however, no data has been reported on the articular cartilage geometry at the contact area. This study investigated the in-vivo tibiofemoral articular cartilage contact biomechanics during a dynamic step-up motion. Methods Ten healthy subjects were imaged using a validated magnetic resonance and dual fluoroscopic imaging technique during a step-up motion. Three-dimensional bone and cartilage models were constructed from the magnetic resonance images. The cartilage contact along the motion path was analyzed, including cartilage contact location and the cartilage surface geometry at the contact area. Findings The cartilage contact excursions were similar in anteroposterior and mediolateral directions in the medial and lateral compartments of the tibia plateau (p>0.05). Both medial and lateral compartments were under convex (femur) to convex (tibia) contact in the sagittal plane, and under convex (femur) to concave (tibia) contact in the coronal plane. The medial tibial articular contact radius was larger than the lateral side in the sagittal plane along the motion path (P<0.001). Interpretations These data revealed that both the medial and lateral compartments of the knee experienced convex (femur) to convex (tibia) contact in sagittal plane (or anteroposterior direction) during the dynamic step-up motion. These data could provide new insight into the in-vivo cartilage contact biomechanics research, and may provide guidelines for development of anatomical total knee arthroplasties that are aimed to reproduce normal knee joint kinematics

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“…Ultimately, contact information is important for understanding the loading and deformation that cartilage tissue undergoes in vivo . To this end, MRI-based displacement encoding sequences have been recently introduced to assess in vivo cartilage tissue strain under cyclic compressive loading conditions [35, 37, 38]. …”

Section: Discussionmentioning

confidence: 99%

Accuracy of model-based tracking of knee kinematics and cartilage contact measured by dynamic volumetric MRI

Kaiser

Monawer

Chaudhary

et al. 2016

Medical Engineering & Physics

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The purpose of this study was to determine the accuracy of knee kinematics and cartilage contact measured by volumetric dynamic MRI. A motor-actuated phantom drove femoral and tibial bone segments through cyclic, 3D motion patterns. Volumetric images were continuously acquired using a 3D radially undersampled cine spoiled gradient echo sequence (SPGR-VIPR). Image data was binned based on position measured via MRI-compatible rotary encoder. High-resolution static images were segmented to create bone models. Model-based tracking was performed by optimally registering the bone models to the volumetric images at each frame of the SPGR-VIPR series. 3D tibiofemoral translations and orientations were reconstructed, and compared to kinematics obtained by tracking fiducial markers. Imaging was repeated on a healthy subject who performed cyclic knee flexion-extension. Cartilage contact for the subject was assessed by measuring the overlap between articular cartilage surfaces. Model-based tracking was able to track tibiofemoral angles and translations with precisions less than 0.8° and 0.5 mm. These precisions resulted in an uncertainty of less than 0.5 mm in cartilage contact location. Dynamic SPGR-VIPR imaging can accurately assess in vivo knee kinematics and cartilage contact during voluntary knee motion performed in a MRI scanner. This technology could facilitate the quantitative investigation of links between joint mechanics and the development of osteoarthritis.

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In vivo articular cartilage deformation: noninvasive quantification of intratissue strain during joint contact in the human knee

Cited by 122 publications

References 55 publications

Indentation mapping revealed poroelastic, but not viscoelastic, properties spanning native zonal articular cartilage

Indentation mapping revealed poroelastic, but not viscoelastic, properties spanning native zonal articular cartilage

Analysis of in-vivo articular cartilage contact surface of the knee during a step-up motion

Accuracy of model-based tracking of knee kinematics and cartilage contact measured by dynamic volumetric MRI

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