In vivo antitumor effect of ascorbic acid, lysine, proline and green tea extract on human colon cancer cell HCT 116 xenografts in nude mice: Evaluation of tumor growth and immunohistochemistry

Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants

“…Liu et al [202] found that that γ-tocotrienol inhibit gastric cancer cell (SGC-7901) proliferation by reducing MMP-1 and -2 activity via modulating the expression of their inhibitor TIMP-1 and TIMP-2. Dietary supplementation of naturally occurring antioxidants, ascorbic acid reduces the size of colon xenograft cancer by downregulation of MMP-9 and VEGF in nude mice [203] . Vitamin E (γ-tocotrienol) effectively inhibits the growth of human gastric cancer in a xenograft mouse model.…”

Inhibition of carcinogenesis by tea constituents

“…Four studies were in xenograft models where human prostate cancer cells were inoculated in immune deficient mice, and the tumor growth was inhibited by oral or i.p. administration of tea extracts or polyphenols [40][41][42][43].…”

Down-regulation of urokinase plasminogen activator and matrix metalloproteinases and up-regulation of their inhibitors by a novel nutrient mixture in human prostate cancer cell lines PC-3 and DU-145

“…Furthermore, a significant negative correlation was found between u-PA and TIMP-2 secretion and between MMP and TIMP-2 secretion by prostate cancer cells. A previous in vivo study of the effects of NM on prostate cancer supports these results in that it demonstrated significant inhibition of PC-3 xenograft tumor growth in nude mice and inhibition of MMP-9 and VEGF secretion and mitosis in the tissue of nutrient-supplemented mice (26). In contrast to the associated toxicity and limited efficacy of standard cancer chemotherapy and radiation therapy, extensive research has documented the efficacy and safety of dietary and botanical natural compounds in cancer prevention (27).…”