In Vivo Antitumor Activity of Polymeric Micelle Anticancer Drug Against Murine C 26 Tumor

A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas

“…Significant C-26 tumor growth inhibition and some cures were attained in mice treated with DOX encapsulated in block copolymer micelles (42)(43)(44), but in all cases, multiple doses of carrier were required, and in one case, therapeutic activity significantly different from free drug was achieved only when each dose was Ͼ100 mg͞kg DOX equivalents (42). To date, the most effective DOX carriers for treatment of this tumor model have been sterically stabilized liposomes.…”

Chitosan-derived Polymer-surfactants and Their Micellar Properties

“…14,15) In this substance, poly-(ethylene glycol) and poly(aspartic acid) act as the hydrophilic and hydrophobic parts, respectively. This substance forms a kind of polymer micelle, but it is different from the polymer micelle of S-Cn-chitosans.…”

Synthesis of Stereoregular Polysaccharide Derivatives Carrying 2,3-Di-O-alkyl Chains

“…3 Some amphiphilic block copolymers form micelle-like structure, usable as drug carriers for controlled chemical derivery. 4 Some hydrophilic polymers having hydrophobic groups also form micelle-like structures in aqueous phase. 5 Recently, Kobayashi et al designed this type of amphiphilic polysaccharide, i.e., synthetic amphiphilic dextran carrying long alkyl chains at C-3 position.…”