In vivo antitumor activity of by-products of Passiflora edulis f. flavicarpa Deg. Rich in medium and long chain fatty acids evaluated through oxidative stress markers, cell cycle arrest and apoptosis induction

Mota, Nádia S.R.S.; Kviecinski, Maicon Roberto; Zeferino, Rodrigo C.; Oliveira, Daniela Alves de; Bretanha, Lizandra C.; Ferreira, Sandra R.S.; Micke, Gustavo Amadeu; Filho, Danilo Wilhelm; Pedrosa, Rozangela Curi; Ourique, Fabiana

doi:10.1016/j.fct.2018.06.010

Cited by 21 publications

(9 citation statements)

References 34 publications

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“…(Dhawan et al, 2004). Modern biochemical and pharmacological studies confirmed that the purified components and crude extracts from P. edulis showed a wide range of in vitro and in vivo bioactivities (Chau and Huang, 2005;Nayak and Panda, 2012;Kinoshita et al, 2013;Otify et al, 2015;Panchanathan and Rajendran, 2015;Silva et al, 2015;Dzotam et al, 2016;Zhang et al, 2016;Ayres et al, 2017;He et al, 2017;Goss et al, 2018;Liu et al, 2018;Mota et al, 2018;Panelli et al, 2018). Table 4 shows the biological activities of main compounds isolated from P. edulis.…”

Section: Biological Activitiesmentioning

confidence: 92%

“…In vivo, the ethanol extract of yellow passion fruit inhibited tumor growth with an inhibition rate of 48.5% and increased mice lifespan to nearly 42% in male Balb/c mice inoculated with Ehrlich carcinoma cells. This could be attributed to the presence of medium and long chain fatty acids such as lauric acid (Mota et al, 2018). Oral or intraperitoneal administration of the polysaccharide showed the inhibition of the growth of sarcoma 180 tumors with an inhibition ratio ranging from 40.59% to 48.73% (Silva et al, 2012).…”

Section: Antitumor Activitymentioning

confidence: 97%

“…Most of the pharmacological work has been carried out on the antitumor activity of P. edulis. In vitro, the different varieties of extracts of P. edulis showed cytotoxicity against HepG 2 (Aguilloń et al, 2018), MCF-7, SW480, SW620, Caco-2 (Ramirez et al, 2017;Sandra et al, 2017;Mota et al, 2018), CCRF-CEM, CEM/ ADR5000, and HCT116 [p53(-/-)] (Kuete et al, 2016). It was found that higher content of polyphenolic and polysaccharide contained in ethanolic extract may be related to the inhibition of matrix-metalloprotease MMP-2 and MMP-9 (Puricelli et al, 2003).…”

Section: Antitumor Activitymentioning

confidence: 99%

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Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology

et al. 2020

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Passiflora edulis, also known as passion fruit, is widely distributed in tropical and subtropical areas of the world and becomes popular because of balanced nutrition and health benefits. Currently, more than 110 phytochemical constituents have been found and identified from the different plant parts of P. edulis in which flavonoids and triterpenoids held the biggest share. Various extracts, fruit juice and isolated compounds showed a wide range of health effects and biological activities such as antioxidant, anti-hypertensive, anti-tumor, antidiabetic, hypolipidemic activities, and so forth. Daily consumption of passion fruit at common doses is non-toxic and safe. P. edulis has great potential development and the vast future application for this economically important crop worldwide, and it is in great demand as a fresh product or a formula for food, health care products or medicines. This mini-review aims to provide systematically reorganized information on physiochemical features, nutritional benefits, biological activities, toxicity, and potential applications of leaves, stems, fruits, and peels of P. edulis.

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Section: Biological Activitiesmentioning

confidence: 92%

Section: Antitumor Activitymentioning

confidence: 97%

Section: Antitumor Activitymentioning

confidence: 99%

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Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology

et al. 2020

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“…Extracts of P. edulis f. flavicarpa were examined for in vitro cytotoxicity in MCF-7 cells, as well as for in vivo antitumor activity in male Balb/c mice inoculated with Ehrlich carcinoma cells. The fluid extract exhibited higher antitumor activity compared to the crude extract, resulting in a 48.5% inhibition of tumor growth in Balb/c mice and increased lifespan by approximately 42% [ 104 ].…”

Section: Medical Effects and Activities In Pharmacymentioning

confidence: 99%

Chemical Compositions, Pharmacological Properties and Medicinal Effects of Genus Passiflora L.: A Review

Nikolova,

Velikova,

Gentscheva

et al. 2024

Plants

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Practically all aboveground plants parts of Passiflora vines can be included in the compositions of dietary supplements, medicines, and cosmetics. It has a diverse chemical composition and a wide range of biologically active components that determine its diverse pharmacological properties. Studies related to the chemical composition of the plant are summarized here, and attention has been paid to various medical applications—(1) anti-inflammatory, nephroprotective; (2) anti-depressant; (3) antidiabetic; (4) hepatoprotective; (5) antibacterial and antifungal; and (6) antipyretic and other. This review includes studies on the safety, synergistic effects, and toxicity that may occur with the use of various dietary supplements based on it. Attention has been drawn to its application in cosmetics and to patented products containing passionflower.

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“…It has been reported that P. edulis seed extract inhibits cancer cell proliferation via human glyoxalase I, the rate-limiting enzyme for the detoxification of methylglyoxal in both NCI-H522 cells and HCT116 cells [45]. P. edulis seed extract by ethanol also shows antitumor activity in MCF-7 cells, and the mechanism of antitumor activity is suggested to be induction of apoptosis via the mitochondrial pathway [91]. An in vivo study demonstrated that when an aqueous extract of P. edulis seeds was administered for 10 weeks, the extract affected the protein levels of p21, cyclin D1, and cyclin-dependent kinase 4; delayed disease progression in the transgenic adenocarcinoma of the mouse prostate model; and decreased the incidence of preneoplastic lesions [92].…”

Section: Other Physiological Effectsmentioning

confidence: 99%

Constituent Characteristics and Functional Properties of Passion Fruit Seed Extract

Kawakami¹,

Morinaga²,

Tsukamoto-Sen³

et al. 2021

Life

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The genus Passiflora L. is widely cultivated in tropical and subtropical regions. The major species, Passiflora edulis Sims, is known as ‘passion fruit’ and is widely used in processed foods as well as eaten raw. P. edulis fruits are eaten for their pulp together with the seeds; however, the seeds are often discarded when used in processed foods. P. edulis seeds contain a variety of nutrients and functional components, and their industrial use is desirable from the perspective of waste reduction. Previous studies have analyzed the constituents of P. edulis and their physiological functions. P. edulis seeds contain various types of polyphenols, especially those rich in stilbenes (e.g., piceatannol). P. edulis seed extracts and isolated compounds from seeds have been reported to exhibit various physiological functions, such as antioxidant effects, improvement of skin condition, fat-burning promotion effects, and hypoglycemic effects. This review summarizes the nutritional characteristics, polyphenol content, and physiological functions of P. edulis seeds.

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In vivo antitumor activity of by-products of Passiflora edulis f. flavicarpa Deg. Rich in medium and long chain fatty acids evaluated through oxidative stress markers, cell cycle arrest and apoptosis induction

Cited by 21 publications

References 34 publications

Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology

Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology

Chemical Compositions, Pharmacological Properties and Medicinal Effects of Genus Passiflora L.: A Review

Constituent Characteristics and Functional Properties of Passion Fruit Seed Extract

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