In vivo Antithrombotic Activity of Ethanolic Extract from Ocimum basilicum L.

Kuerban, Abudukadeer; Almulaiky, Yaaser Q.; Sheikh, Ryan A.; Alzahrani, Saeed; Al-Talhi, Hasan A.; Nasrullah, Mohammad; Moselhy, Said S; Abulnaja, Khalid O.

doi:10.9734/arrb/2017/38047

Cited by 5 publications

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“…Unfortunately, very few in vivo studies are devoted to pro-fibrinolytic action of plant extracts. However, in mice, administration of 200 mg/mL and 400 mg/kg of body weight doses of ethanolic extract of Ocimum basilicum L. shoots has been found to stimulate the fibrinolytic system, resulting in a higher content of fibrin degradation products (FDPs) [ 122 ]. In humans, supplementation with a dried garlic powder (900 mg/day; for 14 days; placebo-controlled study) increased the t-PA activity but did not influence PAI-1 or fibrinogen levels [ 123 ].…”

Section: Pro-fibrinolytic Effects Of Natural Plant-derived Substancesmentioning

confidence: 99%

Plant-Derived Compounds and Extracts as Modulators of Plasmin Activity—A Review

Kołodziejczyk-Czepas

Czepas

2023

Molecules

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Functionality of the fibrinolytic system is based on activity of its central enzyme, plasmin, responsible for the removal of fibrin clots. Besides the hemostasis, fibrinolytic proteins are also involved in many other physiological and pathological processes, including immune response, extracellular matrix degradation, cell migration, and tissue remodeling. Both the impaired and enhanced activity of fibrinolytic proteins may result in serious physiological consequences: prothrombotic state or excessive bleeding, respectively. However, current medicine offers very few options for treating fibrinolytic disorders, particularly in the case of plasmin inhibition. Although numerous attempts have been undertaken to identify natural or to develop engineered fibrinolytic system modulators, structural similarities within serine proteases of the hemostatic system and pleiotropic activity of fibrinolytic proteins constitute a serious problem in discovering anti- or profibrinolytic agents that could precisely affect the target molecules and reduce the risk of side effects. Therefore, this review aims to present a current knowledge of various classes of natural inhibitors and stimulators of the fibrinolytic system being well-defined low-molecular plant secondary metabolites or constituents of plant extracts as well as plant peptides. This work also discusses obstacles caused by low specificity of most of natural compounds and, hence, outlines recent trends in studies aimed at finding more efficient modulators of plasmin activity, including investigation of modifications of natural pharmacophore templates.

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Section: Pro-fibrinolytic Effects Of Natural Plant-derived Substancesmentioning

confidence: 99%

Plant-Derived Compounds and Extracts as Modulators of Plasmin Activity—A Review

Kołodziejczyk-Czepas

Czepas

2023

Molecules

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“…It was observed that administration of 250-500 mg/kg of body weight extract leads to an increase in the brain pool of non-enzymatic and enzymatic antioxidants, thus relating the anti-depressant activity of the extract to this phenomenon. Another study was conducted to determine the antithrombotic effect of ethanolic extract of Ocimum basilicum in mice model carrageenaninduced blood coagulation 115 . Upon administration of 100-400 mg/ml of extract, it was found that the fibrinolytic systems were activated and thus antithrombotic effects were produced, which led to the cardioprotective action of the Ocimum basilicum leaf ethanolic extract.…”

Section: Fig 39: Basil Fig 40: Phytoconstituents Of Basilmentioning

confidence: 99%

Untitled

2022

IJPSR

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Spices are herbs used as flavoring, aromatic, and coloring agents. The culture of various countries even involves the incorporation of spices daily, not just for their culinary potential but also for the health benefits they provide. Many age-old scriptures suggest incorporating the Indian System of Spices in everyday meals to counter many diseases and keep them at bay. The fact that dietary factors play an important role in the treatment as-well-as prevention of diseases makes it all the more important to conduct research and provide scientific evidence regarding the use of culinary species as potential agents with a therapeutic effect. Such culinary spices have various active phytoconstituents, which can have many therapeutic effects and also prove to be great antimicrobial, antidiabetic, anticancer, etc. Generally, most of allopathic drugs are taken individually. Still, unlike them, the spices are consumed in combinations to provide a possible synergistic effect that would be advantageous to us. Also, due to lesser chances of side effects and incorporation of mechanisms to treat any disease right from its root, it would be safer and more practical to head for herbal drugs like these culinary spices for treating all sorts of diseases and various other ailments too. INTRODUCTION:Plants have been a valuable source of natural products for a long period of time to maintain health and wellbeing, especially with more research studies in the last decade for natural therapies. These culinary spices have been used for not only flavoring food and giving aroma but also QUICK RESPONSE CODE

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Biomolecules from Basil – Pharmacological Significance

Dincheva¹,

Badjakov

2022

Biomolecules From Natural Sources

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In vivo Antithrombotic Activity of Ethanolic Extract from Ocimum basilicum L.

Cited by 5 publications

References 0 publications

Plant-Derived Compounds and Extracts as Modulators of Plasmin Activity—A Review

Plant-Derived Compounds and Extracts as Modulators of Plasmin Activity—A Review

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Biomolecules from Basil – Pharmacological Significance

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