In Vivo Antioxidant and Hypolipidemic Effect of Cardiospermum halicacabum Leaf Extract in Streptozotocin-Induced Diabetic Rats

Abstract

In this study we investigated the antioxidant and antihyperlipidemic of an ethanolic leaf extract of Cardiospermum halicacabum (CHE) in plasma and tissues of streptozotocin (STZ)-induced diabetic rats. The plasma and tissue concentrations of thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxide were significantly elevated in STZ diabetic rats. CHE administration decreased TBARS and lipid hydroperoxide levels. The plasma vitamin E level increased and the vitamin C level decreased. The reduced glutathione level significantly decreased in plasma and tissues, as did the activities of enzymatic antioxidants. The enzymatic and non enzymatic alterations reversed toward normalcy after treatment with CHE. STZ-induced diabetic rats showed significant increases in plasma total cholesterol, phospholipids, triglycerides, and free fatty acids, which returned to near normalcy in CHE-treated animals. Plasma LDL-C and VLDL-C increased and HDL-C decreased and both reverted to near normalcy following CHE treatment. We conclude that CHE possesses antioxidant and hypolipidemic effects in diabetic rats, which may be due to the presence of flavonoids, such as apigenin and luteolin in the extract.

Antioxidant, hypoglycemic and anti-diabetic activities of Ziziphus spina-christi (L) Willd (Rhamnacae) leaf extract

“…Streptozotocin selectively destroys the pancreatic β cells, reduce their activity, and cause diabetes [18]. In the present study, significant weight loss was observed in the diabetic group in addition to an improvement in the weight of rats in the diabetic group treated with fraction ZSC-3.…”

Antidiabetic and Antihyperlipidaemic Activity of Nelumbo Nucifera Gaertn Ethanol Seed Extract in Streptozotocin Induced Diabetic Rats

“…In the present study, it was observed that there is a reduction in body weight of the STZ induced diabetic rats which may be due to catabolism of fats and protein [33]. The administration of NNSE improve body weight compared to diabetic control rats, which indicates the preventive effect of plants on the degradation of proteins.…”

Formulation and Evaluation of Novel Herbal Aerosol for Arthritis

“…Anti-inflammatory properties of CH have been researched [11], but no clinical trials have been reported so far. Experimental pharmacological studies of CH have shown antioxidant activity [12] analgesic and vasodepressant activities [13], antipyretic activity [14], Antimalarial activity [15], diuretic activity [16], anti-diarrheal activity [17], anti-diabetic activity [18] and anti-ulcer activity [19].…”