In vivo antidiabetic and antioxidant potential of Helichrysum plicatum ssp. plicatum capitulums in streptozotocin-induced-diabetic rats

Aslan, Mustafa; Orhan, Didem Deliorman; Orhan, Nilüfer; Sezik, Ekrem; Yeşilada, Erdem

doi:10.1016/j.jep.2006.07.001

Cited by 131 publications

(87 citation statements)

References 25 publications

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“…Unfortunately, in systems where water and alcohol are the extraction solvents, mainly polar compounds will be extracted thus limiting the amount of active compounds obtainable from plants. activity and flavonoid content [47,48]. There is also a possibility that the compounds facilitating the glucose utilization activity of the C2C12 muscle cells may be different from that stimulating the glucose utilization activity of the 3T3-L1 adipocytes.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening, Antioxidant, Anti-inflammatory, and Glucose Utilization Activities of Three South African Plants Used Traditionally to Treat Diseases

Olaokun¹,

Mkolo²,

Mogale³

et al. 2017

Biol Med

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Medicinal plants are important in the treatment of human diseases. The medicinal properties of plants are attributed to the presence of secondary plant metabolites. Polyphenols, particularly fl avonoids, are phytochemicals that possess antioxidant and anti-infl ammatory activity, and modulate pathways involved in obesity and glucose metabolism. In folk medicine, a single plant may be used to treat various diseases owing to the presence of phytochemical varieties in plants. In this study, the acetone leaf extracts of Curtisia dentata, Pittosporum viridifl orum, and Portulacaria afra were investigated for total polyphenol and total fl avonoid content as well as for anti-infl ammatory, antioxidant, and glucose utilization activities by using standard methods. The C. dentata extract exhibited the highest polyphenols (125.12  2.18 mg/g GAE) and fl avonoids (27.69  4.98 mg/g QE). The P. viridifl orum extract exhibited the strongest DPPH radical antioxidant activity (IC 50 value 5 12.94  1.09 µg/ml) and anti-infl ammatory activity by inhibiting 5-lipoxygenase activity (IC 50 value 5 46.50  4.54 µg/ml). All extracts enhanced dose-dependent glucose utilization activity of muscle cells and adipocytes. P. viridifl orum enhanced the highest glucose utilization of C2C12 muscle cells (67.34  0.51%), while C. dentata enhanced the highest glucose utilization of 3T3-L1 adipocytes (63.72  0.48%) at the highest concentration of 500 µg/ml, with no signifi cant difference (p  0.05). Polyphenols may be responsible for the observed 3T3-L1 cells glucose utilization activity of C. dentata. However, the polyphenols alone may not be responsible for the antioxidant, anti-infl ammatory, and C2C12 cells glucose utilization activity of P. viridifl orum. To our knowledge, this is the fi rst study to demonstrate the glucose utilization potential of the species of medicinal plants.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Screening, Antioxidant, Anti-inflammatory, and Glucose Utilization Activities of Three South African Plants Used Traditionally to Treat Diseases

Olaokun¹,

Mkolo²,

Mogale³

et al. 2017

Biol Med

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“…The method described by Aslan et al (2007) was adopted for this study. Thirty mature male albino rats were fasted for 18 h and were randomly divided into five groups of six rats each.…”

Section: Effect Of Gle On Oral Glucose Tolerance Test (Ogtt) In Ratsmentioning

confidence: 99%

Antidiabetic, antilipidemic, and antioxidant activities ofGouania longipetalamethanol leaf extract in alloxan-induced diabetic rats

Ezeja

Anaga

Asuzu

2014

Pharmaceutical Biology

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Context: Gouania longipetala Hemsl. (Rhamnaceae) is used in folkloric medicine for treating diabetes mellitus and its associated symptoms. Objective: This study evaluated the antidiabetic antilipidemic and antioxidant activities of the plant methanol leaf extract. Materials and methods: Diabetes was induced in rats by intraperitoneal injection of alloxan monohydrate (160 mg/kg). Three test doses (50, 100, and 150 mg/kg) of G. longipetala extract (GLE) were administered orally and the effects were compared with glibenclamide (2 mg/kg). The effect of GLE on hyperglycemia and sub-acute study for 21 d were carried out using its effect on fasting blood sugar (FBS) level. Serum biochemistry and antioxidant activity were evaluated. Histopathological evaluation of the pancreas was also done. Results: The LD 50 of G. longipetala was found to be 44000 mg/kg. The extract significantly (p50.0001) decreased the FBS levels of treated rats from 16.2 ± 2.03 to 6.5 ± 1.52 mM/L at 150 mg/kg within 24 h. The extract decreased FBS levels of rats by 62.0, 74.8, and 75.0% on day 21 at 50, 100, and 150 mg/kg, respectively. GLE reduced the level of malondiadehyde from 23.0 ± 1.34 to 10.3 ± 0.43 mg/dL, increased superoxide dismutase activities from 2.97 ± 0.34 to 5.80 ± 0.53 IU/L at 150 mg/kg, and improved the serum lipid profile of treated rats. GLE also caused restoration of the altered histopathological changes of the pancreas. Discussion and conclusion: Gouania longipetala demonstrated significant antidiabetic, antilipidemic, and antioxidant activities that may be due to its multiple effects involving both pancreatic and extra-pancreatic mechanisms.

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“…After overnight fasting, diabetes was induced by intraperitoneal injection of streptozotocin (STZ) (Sigma, St. Louis, MO) dissolved in 0.1 M cold sodium citrate buffer, pH 4.5, at a dose of 55 mg/kg [23] . The control rats received the vehicle alone.…”

Section: Induction Of Diabetesmentioning

confidence: 99%

Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats

Gandhi¹,

Sasikumar

2012

Asian Pacific Journal of Tropical Biomedicine

111

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In vivo antidiabetic and antioxidant potential of Helichrysum plicatum ssp. plicatum capitulums in streptozotocin-induced-diabetic rats

Cited by 131 publications

References 25 publications

Phytochemical Screening, Antioxidant, Anti-inflammatory, and Glucose Utilization Activities of Three South African Plants Used Traditionally to Treat Diseases

Phytochemical Screening, Antioxidant, Anti-inflammatory, and Glucose Utilization Activities of Three South African Plants Used Traditionally to Treat Diseases

Antidiabetic, antilipidemic, and antioxidant activities ofGouania longipetalamethanol leaf extract in alloxan-induced diabetic rats

Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats

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