In vivo Anticoccidial and Antioxidant Activities of Psidium guajava Methanol Extract

Cédric, Yamssi; Payne, Vincent Khan; Nadia, Noumedem Anangmo Christelle; Kodjio, Norbert; Kollins, Etung; Megwi, Leonelle; Jules-Roger, Kuiate; Mbida, Mpoame

doi:10.9734/ejmp/2017/36573

Cited by 11 publications

(11 citation statements)

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“…Eimeria stiedae is one of the most pathogenic coccidian protozoans in domestic rabbits ( Oryctolagus cuniculus ), causing severe hepatic coccidiosis, a reduced growth rate, decreased feed conversion, and increased mortality [ 1 , 2 , 3 , 4 , 5 , 6 ]. The limitations of certain chemical drugs and weight promoters have increased digestive disorders and the occurrence of death in rabbits.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Litchi chinensis Peel Extract-Prepared Nanoparticles on Rabbits Experimentally Infected with Eimeria stiedae

Metwally

Alkhuriji

Barakat

et al. 2022

Animals

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The present study used Litchi chinensis peel extract to synthesize silver nanoparticles (AgNPs). This technique is eco-friendly and can be performed in a single step; thus, it has attracted great attention for NP biosynthesis. Herein, we biosynthesized AgNPs with L. chinensis peel extract and examined their anticoccidial activity in rabbit hepatic coccidiosis induced by E. stiedae infection. Thirty-five rabbits were allocated into seven groups: a healthy group (G1), an infected control group (G2), four groups infected before treatment with 10 mg/kg L. chinensis peel extract-biosynthesized AgNPs (G3, G5) or 50 mg/kg amprolium (G4, G6), and rabbits infected after two weeks of pretreatment with 10 mg/kg L. chinensis eel extract-biosynthesized AgNPs (G7). In this study, both pre-and post-treatment with AgNPs produced a substantial reduction in fecal oocyst output, liver enzyme levels, and histopathological hepatic lesions relative to the infected group. In conclusion, L. chinensis peel extract-prepared AgNPs should be considered harmless and efficient in the cure of hepatic coccidiosis in rabbits.

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Section: Introductionmentioning

confidence: 99%

Protective Effect of Litchi chinensis Peel Extract-Prepared Nanoparticles on Rabbits Experimentally Infected with Eimeria stiedae

Metwally

Alkhuriji

Barakat

et al. 2022

Animals

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“…Yang et al (2015) reported that Bidens pilosa, which is rich in flavonoids, has anticoccidial activity in chickens infected with E. tenella. Cedric et al (2017) also reported the inhibitory effect of flavonoids against oocyst sporulation of the oocyst of Eimeria spp. in rabbits in vitro.…”

Section: Discussionmentioning

confidence: 96%

Phytochemical Profile of the Methanolic Leaf Extract of Vernonia amygdalina Del. and In Vitro Anticoccidial Effect of Its Fractions against Eimeria tenella

Biallah¹,

Lawal²,

Abdu³

et al. 2022

ijird

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Phytochemical screening of the crude methanolic leaf extract of Vernonia amygdalina was carried out. The extract and its fractions were tested for in vitro anticoccidial efficacy against the unsporulated oocysts of Eimeria tenella by the oocyst sporulation inhibition model in a 96-well microtitre plate. Phytochemical analysis of the extract revealed the presence of alkaloids, tannins, saponins, glycosides, and triterpenoids. Different concentrations of the extracts, including 250 mg/ml, 125 mg/ml, 62.5 mg/ml, 31.25 mg/ml, 15.625 mg/ml, and 7.8 mg/ml, were tested against freshly prepared unsporulated oocysts of E. tenella. Triplicate assays were conducted for each concentration of the extract to screen for anticoccidial activity. The methanol extract and fractions showed activity against the oocysts of E. tenella in a dose-dependent manner. The sporulation inhibition rate was determined as effective when the result showed more than 50% inhibition at each concentration level of treatment. Only the methanol extract and its butanol fraction at the lowest treatment concentration of 7.8 mg/ml showed an inhibition rate of 55% and 68%, respectively. All treatments: methanol extract (100%), hexane fraction (100%), butanol fraction (100%), and aqueous residue fraction (58%) were active at the highest concentration of 250 mg/ ml. It is concluded that the methanol leaf extract of Vernonia amygdalina and its butanol fraction had better oocyst sporulation inhibition activity against Eimeria tenella and may further be explored for their anticoccidial properties.

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“…The number of oocysts in faeces is a crucial indicator of the spread of coccidiosis in farms due to the transmission of Eimeria oocysts by the faecal-oral route. According to reports from previous studies ( Cervantes-Valencia et al., 2015 ; Cedric et al., 2017 ; Aboelhadid et al., 2019 ; Qaid et al., 2021 ), the number of faecal oocysts in rabbits infested with coccidia is effectively reduced in response to the medicinal plants used.…”

Section: Discussionmentioning

confidence: 99%

In vivo anticoccidial activity and immune response of Moringa oleifera and Vernonia amygdalina leaves against Eimeria magna and Eimeria media in rabbits

Konmy

Olounladé

Adjobimey

et al. 2023

Front. Cell. Infect. Microbiol.

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IntroductionThe aims of this study were to determine the immune response and the anticoccidial activity induced by Moringa oleifera and Vernonia amygdalina leaves in rabbits infected with Eimeria magna and Eimeria media.MethodsThirty-five-day-old rabbits, free from coccidia, were infested with 2.103 oocysts of Eimeria magna and Eimeria media, then received the acetone extract of the leaves of Moringa oleifera and Vernonia amygdalina at different doses by oral gavage.Results and discussionThe inhibition of the excretion of oocysts was evaluated by the McMaster technique and the levels of cytokines (IL-4 and IL-12) and immunoglobulin IgG were assayed by the ELISA method. The in vivo efficacy on E. magna and E. media oocysts was 95.43% and 96.53% for Moringa oleifera and Vernonia amygdalina at 1000 mg/kg bw against 98% for the positive control. Interestingly the plant extracts increased the production of interleukin (IL) and immunoglobulins (Ig) compared to controls. Plasma IL-4 levels (pg/ml) in rabbits were 128.94 and 131.38; those of IL-12 (pg/ml) were 395.55 and 426.56, and then for those of IgG (μg/ml) were 14.70 and 13.94 respectively with the acetone extracts of Moringa oleifera and Vernonia amygdalina on D14 PT at 1000 mg/kg bw. This study indicates that Moringa oleifera and Vernonia amygdalina can be used as an alternative to synthetic anticoccidials. These plants could be used to increase the resistance of the immune system of rabbits to infestations of Eimeria species in rabbit farms.

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In vivo Anticoccidial and Antioxidant Activities of Psidium guajava Methanol Extract

Cited by 11 publications

References 0 publications

Protective Effect of Litchi chinensis Peel Extract-Prepared Nanoparticles on Rabbits Experimentally Infected with Eimeria stiedae

Protective Effect of Litchi chinensis Peel Extract-Prepared Nanoparticles on Rabbits Experimentally Infected with Eimeria stiedae

Phytochemical Profile of the Methanolic Leaf Extract of Vernonia amygdalina Del. and In Vitro Anticoccidial Effect of Its Fractions against Eimeria tenella

In vivo anticoccidial activity and immune response of Moringa oleifera and Vernonia amygdalina leaves against Eimeria magna and Eimeria media in rabbits

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