In-vivo anticancer activity of Curcumin-Hyaluronic acid conjugate

Abstract

Objective: Polymer-drug conjugates have gained much attention largely to curcumin lower drug solubility and to enhance drug stability. Curcumin is widely known for its medicinal properties including its anticancer efficacy. One of the serious drawbacks of curcumin is its poor water solubility which leads to reduced bioavailability. Materials and methods: Curcumin-HA conjugate was assessed for anticancer activity in EAC induced mice. And haematological parameters, differential count, body weight changes and mean survival time was assessed. Results: The results showed Conjugate (HA-Cur) produced extremely significant as anticancer activity by change in haematological parameters, differential count, body weight changes and mean survival time. Conclusion: Conjugated curcumin also showed potential anticancer activity.

Microwave-Assisted, Solid-State Procedure to Covalently Conjugate Hyaluronic Acid to Curcumin: Validation of a Green Synthetic Protocol

“…The main hurdle of using CUR for treatment of diseases is its poor solubility and lack of stability in aqueous medium, in particular in basic–neutral conditions, − so that several attempts have been made to enhance its bioavailability in the bloodstream. For instance, CUR has been encapsulated in the inner core of carriers, such as chitosan, hyaluronan, poly(lactic- co -glycol acid), and so on, − and chemically conjugated to natural polysaccharides in order to develop amphiphilic nanocarriers of CUR. − Hyaluronic acid (HA), as a hydrosoluble polysaccharide, increases the solubility and bioavailability of CUR, while providing its own additional biological benefits (antimicrobial, anti-inflammatory, antioxidant, wound-repairing effects). − …”