In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase

Nagai, Takayuki; Miyaichi, Yukinori; Tomimori, Tsuyoshi; Suzuki, Yujiro; Yamada, Hideaki

doi:10.1016/0166-3542(92)90080-o

Cited by 81 publications

(48 citation statements)

References 17 publications

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“…Figure 5) isolated from the roots of Scutellaria baicalensis, was shown to have a specific inhibitory activity against influenza virus NA because it did not affect the mouse liver NA activity [84,85]. F36 inhibited the proliferation of influenza virus in MDCK cells, in the allantoic sac of embryonal chicken egg and in vivo using BALB/c mice [85][86][87]. Immunoelectron microscopic analysis revealed that F36 inhibited the budding of progeny influenza virus particles from MDCK cell surface and microvilli [88].…”

Section: Flavonoidsmentioning

confidence: 99%

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

2011

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Section: Flavonoidsmentioning

confidence: 99%

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

2011

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“…Moreover, it is important to highlight that despite the presence of lower amounts of isoscutellarein derivatives as compared to those of phenylethanoid glycosides, these can also be key components on the ethnopharmacological effects of the plant. Indeed, for the last decades, isoscutellarein derivatives have also been described to exert important beneficial activities as antiviral, antioxidant, cytotoxic, antinociceptive, anti-inflammatory and inhibitory activity against osteoclastogenesis (Kupeli, Sahin, Yesilada, Calis, & Ezer, 2007;Nagai, Miyaichi, Tomimori, Suzuki, & Yamada, 1992;Yang et al, 2003;Yoon, Jeong, Hwang, Ryu, & Kim, 2007).…”

Section: Quantification Of Phenolic Compounds In Peelmentioning

confidence: 99%

Phenolic constituents of Lamium album: Focus on isoscutellarein derivatives

Pereira

Domingues

Silva

et al. 2012

Food Research International

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Lamium album L. is an edible plant which is consumed raw or cooked, in particular in the Mediterranean and surrounding areas. It is also consumed as tea infusions and as a main component of food supplements, because of its pharmacological effects. Despite being consumed by humans for centuries, the chemical composition of L. album L. is far from being understood. In this study, a purified ethanolic extract (PEEL) was prepared and further analyzed by high performance liquid chromatography and electrospray mass spectrometry. Overall, verbascoside accounted for approximately half of the phenolic content of the extract, but this also contained other bioactive phenolic compounds herein detected for the first time in the genus, namely isoscutellarein derivatives. The latter included isoscutellarein-7-O-allosyl(1 →2)glucoside, its O-methyl derivative, three acetyl derivatives of isoscutellarein-Oallosyl glucoside and one acetylated form of O-methylisoscutellarein-7-O-allosyl(1 →2)glucoside. From those, the main isoscutellarein derivative was assigned to isoscutellarein-7-O-(6-O-acetyl-β-allosyl)(1→2)-β-glucoside, as confirmed by NMR. Altogether, isoscutellarein derivatives accounted for almost 30% of PEEL phenolics. Since verbascoside and isoscutellarein derivatives are main components of L. album L. ethanolic extract, their possible association to the health benefits of the plant is discussed.

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“…[11][12][13][14][15][16] In general, the structures of flavonoids consist of three aromatic rings designated as ring A, B and C based on the sequence of their biogenesis. The plants synthesize a two-ring intermediate chalcone first and then form a bicyclic fused A/C ring system appended with a B-ring.…”

mentioning

confidence: 99%

Synthesis and Anti-influenza Activities of Novel Baicalein Analogs

Chung

Chien

Yao

et al. 2014

CHEMICAL & PHARMACEUTICAL BULLETIN

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A series of novel flavones derivatives were synthesized based on modification of the active ingredients of a traditional Chinese medicine Scutellaria baicalensis GEORGI and screened for anti-influenza activity. The synthetic baicalein (flavone) analogs, especially with the B-rings substituted with bromine atoms, were much more potent than oseltamivir or ribavirin against H1N1 Tamiflu-resistant (H1N1 TR) virus and usually with more favorable selectivity. The most promising were 5b, 5c, 6b and 6c, all displaying an 50% effective concentration (EC 50 ) at around 4.0-4.5 µM, and a selective index (SI 50% cytotoxic concentration (CC 50 )/ EC 50 )>70. For seasonal H3N2-infected influenza virus, both 5a and 5b with SI >17.3 indicated superior to ribavirin. The flavonoids having both not-naturally-occurring bromo-substituted B-rings and appropriate hydroxyls positioning on the A-rings might be critical in determining the activity and selectivity against H1N1-Tamiflu-resistant infected influenza viruses.

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In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase

Cited by 81 publications

References 17 publications

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

Phenolic constituents of Lamium album: Focus on isoscutellarein derivatives

Synthesis and Anti-influenza Activities of Novel Baicalein Analogs

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