In vivo anti-inflammatory activity of anti-atherosclerotic herbs using white male rats (Rattus norvegicus)

Tristantini, Dewi; Amalia, Riska

doi:10.1063/1.5139348

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…Generally, after administration of carrageenan, the in ammation founds around 2-4 ml in rats weighing around 175-200g but in cases of our study, the animals used of more than 350g weight due to the availability of animals at the time of the study. Due to using the high weight of animals, the paw volume was changed [22][23][24] . In addition, we have measured the paw from the starting point of the bula to maintain uniformity therefore the paw volume was found higher.…”

Section: Carrageenan-induced Rat Paw Edemamentioning

confidence: 99%

Synthesis, in-silico and anti-inflammatory activities of novel coumarin derivatives

Yadav

Gupta

Kumar

et al. 2022

Preprint

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With the advancement of anti-inflammatory drugs, the achievement of a desired therapeutic action is always jeopardized because of several biological factors. The objective of this study is to explore the anti-inflammatory potential of coumarin synthesizers using in-silico and in-vivo approaches. A series of 20 coumarin derivatives have been synthesized into two different schemes (Schemes 1 and 2) and explored for anti-inflammatory potential against TNF-α- and carrageenan -induced inflammation, respectively. The results of the study revealed an important anti-inflammatory potential demonstrated by compound 8 of Scheme 1 and compounds 1 and 4 of Scheme 2 against inflammation caused by carrageenan. In addition, there was a significant reduction (p < 0.001) in inflammatory cytokines (TNF-α, IL-6 and IL-1β). In light of this, the study reveals the anti-inflammatory potential of synthetic coumarin, compounds 8, 1 and 4 of both regimens being the most effective anti-inflammatory.

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Section: Carrageenan-induced Rat Paw Edemamentioning

confidence: 99%