In vivo anti-hyperuricemia and anti-gouty arthritis effects of the ethanol extract from Amomumvillosum Lour.

Liu, Dong; Zhang, Shanhui; Chen, Lina; Zhao, Fuhui; Long, Tiemei; Wen, Jinlan; Huang, Jiayu; Mao, Yuanhu; Qi, Zhengfang; Zhang, Jiquan; Li, Lei; Dong, Yong‐Xi

doi:10.1016/j.biopha.2023.114532

Cited by 8 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1,2 GA typically presents with painful redness, swelling, and even restricted movement of joints. 3 The incidence of GA is on the rise in the past 10 years and shows a younger trend, and men are more prone to GA onset than women. 4,5 Moreover, GA patients at the advanced stage are vulnerable to severe complications such as cardio-cerebrovascular disease, kidney disease, and liver disease, which significantly compromise the quality of life and pose heavy economic burdens.…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese Medicine is Associated with the Reduction in Endpoint Events in Patients with Gouty Arthritis: Cohort Study and Association Rule Analysis

Chen,

Liu,

Cong

et al. 2024

IJGM

View full text Add to dashboard Cite

This study aimed to evaluate the effect of traditional Chinese medicine (TCM) on endpoint events in patients with gouty arthritis (GA). Methods and Materials: A total of 2091 hospitalized GA patients were followed up by telephone, and propensity score matching (PSM) was used to reduce potential bias in the study design. Cox proportional risk model and Kaplan-Meier survival curve were utilized to analyze the impact and time effect of factors on the readmission of GA patients. The differences of laboratory indexes before and after treatment between the low and high exposure groups were compared, and the types and frequencies of medicines in all patients were counted. Association rule analysis was performed to investigate the association between TCM and test indexes or endpoint events. Results: After 1:1 PSM, 187 patients were enrolled in the TCM group and 187 patients in the non-TCM group. The incidence of readmission, new tophus, and all-cause death was lower in the TCM group than that in the non-TCM group (P < 0.05). Cox proportional risk regression analysis showed that TCM, NSAIDs and uric acid lowering drug were independent protective factors for GA readmission. The protective effect was enhanced by the prolongation of TCM treatment and the drug combinations. Kaplan-Meier survival curves indicated a significantly lower readmission rate in the high exposure group than in the low exposure group (P < 0.01). Compared with before treatment, NLR, hs-CRP, UA, TC and other laboratory indexes of the low and high exposure groups were improved after treatment (P < 0.01); The improvement of TG and TC in the high exposure group was more significant than the low exposure group (P < 0.01). The analysis of medicines used by all patients identified the top 20 Chinese herbal medicines and the top 2 Chinese patent medicines. The core drugs identified through association rule analysis that can improve test index and reduce the incidence of endpoint events include Yiyiren, Danshen, and HQC, among others. The network diagram of association rule analysis intuitively shows the relationship between core drugs and "improvement of indicators" and "the absence of endpoint events". Conclusion: TCM is associated with a reduced incidence of endpoint events in patients with GA.

show abstract

Section: Introductionmentioning

confidence: 99%

Traditional Chinese Medicine is Associated with the Reduction in Endpoint Events in Patients with Gouty Arthritis: Cohort Study and Association Rule Analysis

Chen,

Liu,

Cong

et al. 2024

IJGM

View full text Add to dashboard Cite

show abstract

“…could treat hyperuricemia by decreasing the production of UA via XO inhibition and increasing the excretion of UA via regulation of urate transporters (OAT1, ABCG2, URAT1, and GLUT9). In addition, the extract showed a certain protective effect on hepatic and renal damage caused by hyperuricemia by decreasing the expression of inflammatory cytokines (IL‐1β, IL‐6, and TNF‐ɑ) (Dong et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences

Mahomoodally,

Coodian,

Hosenally

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

Gout, or hyperuricemia is a multifactorial and multi‐faceted metabolic disease that is quite difficult to manage and/or treat. Conventional therapies such as non‐steroidal anti‐inflammatory drugs (NSAIDs) such as allopurinol, corticosteroids and colchicine amongst others, have helped in its management and treatment to some extent. This study aimed to compile and analyze the different herbal remedies used in the management of hyperuricemia and gout. A literature search was conducted from key databases (PubMed, ScienceDirect, Cochrane Library, Google Scholar) using relevant keywords via the PRISMA model. Smilax riparia A.DC. from Traditional Chinese Medicine is used in many countries for its therapeutic effect on lowering serum urate levels. No single study was able to establish the efficacy of a specific traditionally used herb via in vitro, in vivo, and clinical studies. Patients were found to use a panoply of natural remedies, mainly plants to treat hyperuricemia and gout, which have been validated to some extent by in vitro, in vivo, and clinical studies. Nonetheless, further research is needed to better understand the ethnopharmacological relationship of such herbal remedies.

show abstract

Antioxidant aromatic compounds from Amomum villosum and target prediction of active ingredients

Liang,

Xu,

Chen

et al. 2024

Bioorganic Chemistry

View full text Add to dashboard Cite

In vivo anti-hyperuricemia and anti-gouty arthritis effects of the ethanol extract from Amomumvillosum Lour.

Cited by 8 publications

References 41 publications

Traditional Chinese Medicine is Associated with the Reduction in Endpoint Events in Patients with Gouty Arthritis: Cohort Study and Association Rule Analysis

Traditional Chinese Medicine is Associated with the Reduction in Endpoint Events in Patients with Gouty Arthritis: Cohort Study and Association Rule Analysis

Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences

Antioxidant aromatic compounds from Amomum villosum and target prediction of active ingredients

Contact Info

Product

Resources

About