In vivo Anti-Cancer Activity of RC-18

Adwankar, Manohar; Chitnis, M.P.

doi:10.1159/000238092

Cited by 31 publications

(14 citation statements)

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“…Beyond that mentioned skeleton, uncommonly, chloroform-soluble portion of methanol extracts from the roots of R . cordifolia gave a dimer named RA-dimer A (103), in which two molecules of deoxybouvardin were linked together via an ether linkage [59]; however, it’s a pity for us that chemical constructions of RA-700 and RC-18 haven’t been available [60,61]. Just in last year, Y. Hitotsuyanagi etc .…”

Section: Reviewmentioning

confidence: 99%

Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia

Wang

Yuan

et al. 2013

Chemistry Central Journal

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Genus Rubia fell into about 70 species distributed widely around the world, a total of 36 species and 2 varieties were reported from China. The extracts and phytochemicals of Rubia plants had drawn considerable attention due to their potent bioactivities. As the two major ingredients from these plants, pentacyclic triterpenes and cyclopeptides were becoming a hot topic over the past twenty years for their remarkable anticancer, antioxidant and other effects. This paper compiled all 65 terpenes and 44 cyclopeptides with their distributions, physiological activities and melting points (or optical rotations) as reported in 85 references; besides, structure-activity relationships of these derivatives were briefly discussed. The information involved in this paper was expected to be meaningful for the further studies of the Genus Rubia.

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Section: Reviewmentioning

confidence: 99%

Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia

Wang

Yuan

et al. 2013

Chemistry Central Journal

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“…However, it failed to show any inhibitory effect on solid tumors, Lewis lung carcinoma, and sarcoma 180. Promising results against a spectrum of experimental tumors suggest that RC-18 may lead to the development of a potential anticancer agent [93]. But the structure of RC-18 has not been established.…”

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confidence: 99%

9,10‐Anthraquinones and Other Biologically Active Compounds from the Genus Rubia

Savan

Geetanjali

Chauhan

2004

Chemistry & Biodiversity

120

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The secondary metabolites isolated from Rubia species, their biological activities, and colouration properties have been reviewed. Over 150 chemical constituents belonging to different classes of bioactive compounds such as anthraquinones and their glycosides, naphthoquinones and glycosides, terpenes, bicyclic hexapeptides, iridoids, and carbohydrates are listed together with their source(s) and corresponding references.

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“…25) The other medicinal plants like Ervatamia heyncana, Rubia cordifolia, Hygrophila spinosam, Tylophora indica, Podophyllum hexandru and Hygrophila spinosa have been reported to possess antineoplastic activity. [26][27][28][29][30][31] The administration of AME for nine days induced toxic effects in the form of debility, loss of body weight and death and did not prolong survival. Therefore 6 d regimen was considered best for the antineoplastic activity of AME and further experiments were carried out with this regimen.…”

Section: Discussionmentioning

confidence: 99%

Aegle marmelos (L.) CORREA Inhibits the Proliferation of Transplanted Ehrlich Ascites Carcinoma in Mice

Jagetia

Venkatesh

Baliga

2005

Biological & Pharmaceutical Bulletin

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The anticancer effect of hydroalcoholic extract of Aegle marmelos (AME) was studied in the Ehrlich ascites carcinoma bearing Swiss albino mice. The spatial effect of various AME administration schedules showed that six-day administration increased the survival of tumor bearing mice. The best antineoplastic action of AME was obtained when AME administered through intraperitoneal route than the oral route at equimolar dose. Administration of AME once daily for six consecutive days to the tumor bearing mice caused a dose dependent remission of the tumor at 400 mg/kg body weight, where the greatest antitumor effect was observed and the higher doses showed toxic manifestations. A 24-d lengthening in life span was observed in EAC animals treated with 400 mg/kg AME. This dose of 400 mg/kg was considered as the best dose, where the animals survived up to 43 d post-tumor-cell inoculation as against no survivors in the saline treated control group. The antitumor activity when tested for different schedules for triple administrations, the best effect was observed for 1-2-3, followed by 1-3-5 and 1-5-9 days, respectively. Stage specific evaluation of AME inhibited the increase in body weight gain in animals due to tumor development during early stages only. The AME treatment resulted in a dose dependent elevation in the median survival time (MST) and average survival time (AST) up to 400 mg/kg AME and decline thereafter. The effective dose of 400 mg of AME is 1/6th of the LD 50 dose, which increased the MST and AST up to 29 and 27 d, respectively. The acute toxicity study of AME showed that the drug was non-toxic up to a dose of 1750 mg/kg b. wt. The LD 10 and LD 50 was found to be 2000 and 2250 mg/kg.

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In vivo Anti-Cancer Activity of RC-18

Cited by 31 publications

References 0 publications

Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia

Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia

9,10‐Anthraquinones and Other Biologically Active Compounds from the Genus Rubia

Aegle marmelos (L.) CORREA Inhibits the Proliferation of Transplanted Ehrlich Ascites Carcinoma in Mice

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