In vivo Anthelmintic Activity of Terminalia glaucescens (Combretaceae) Extracts against Gastrointestinal Nematodes of Sheep

Lem, Mbafor Fidelia; Payne, VK; Poné, J. Wabo; Gertrude, Mbogning Tayo; Tchoumboué, J.

doi:10.9734/bjpr/2014/12936

Cited by 4 publications

(2 citation statements)

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“…Anthelminthic activity of onion (Allium cepa L.) and coconut (Cocos nucifera L.) is described in the study by Mehlhorn et al (2011). Lem et al (2014) point to anthelminthic activity in vivo of Terminalia glaucescens (Combretaceae). Marley et al (2003) found that in Great Britain, lambs which grazed in a pasture with Cichorium intybus L. and Lotus corniculatus L. were less infested than lambs which were grazing on perennial ryegrass and white clover (Lolium perenne L., Trifolium repens L.).…”

Section: Discussionmentioning

confidence: 99%

Nematocidial activity of aqueous solutions of plants of the families Cupressaceae, Rosaceae, Asteraceae, Fabaceae, Cannabaceae and Apiaceae

Boyko

Brygadyrenko

2019

Biosys. divers.

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In natural ecosystems of animals, introduction of larvae of parasitic nematodes into the litter layer from excrement facilitates their migration and search of new host vertebrate animals. In such conditions they are constantly affected by biologically active substances of the abundant species of plants which grow in pastures. Currently, the influence of substances present in the above-ground part of plants on the vitality of larvae of helminths in the environment remains unstudied. In this article, we present the results of our research on the nematocidial activity in vitro in the aqueous solutions of 21 species of plants distributed in the territory of Steppe Ukraine: Sanguisorba officinalis L., Rosa canina L., Crataegus sanguinea Pall., Crataegus pentagyna Waldst. & Kit. ex Willd., Armeniaca vulgaris Lam., Taraxacum officinale F. H. Wigg., Iva xanthiifolia Nutt., Artemisia campestris L., Arctium minus (Hill) Bernh., Ambrosia artemisiifolia L., Cannabis sativa L., Humulus lupulus L., Melilotus officinalis (L.) Pall., Vicia cracca L., Lotus ucrainicus Klok., Onobrychis arenaria (Kit.) DC., Foeniculum vulgare Mill., Eryngium planum L., Conium maculatum L., Juniperus communis L., Thuja occidentalis L. The level of vitality of nematode larvae of the Strongylida (Haemonchus contortus (Rudolphi, 1803)) and Rhabditida (Strongyloides papillosus (Wedl, 1856)) orders varied depending on the species of plant, and also five experimental concentrations in aqueous solutions tested in seven replications. The most notable nematocidial effect was exerted by Taraxacum officinale F. H. Wigg. – we observed death of larvae of third stage development L3 H. contortus and larvae of first-third stages L1–3 S. papillosus at 24 h exposure to 3% aqueous solution. Three percent aqueous solutions of S. officinalis and A. artemisiifolia displayed nematocidial properties only against S. papillosus: death of L1–3 S. papillosus was observed. Aqueous solutions of R. canina, A. vulgaris, A. minus, H. lupulus, V. cracca, L. ucrainicus, O. arenaria, E. planum, C. maculatum, J. communis, Th. occidentalis had lethal effect only on non-invasive larvae (larvae of the first and second stage L1–2) of S. papillosus. They displayed no nematocidial properties towards invasive larvae of H. contortus and S. papillosus. At exposure to aqueous solutions of the rest of the studied species of plants, over 50% of L3 H. contortus and L1–3 S. papillosus larvae remained alive. The determined patterns allow us to state that while living in the litter and soil in the root zone of plants nematode larvae undergoa negative influence caused by some plant species.

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Section: Discussionmentioning

confidence: 99%

Nematocidial activity of aqueous solutions of plants of the families Cupressaceae, Rosaceae, Asteraceae, Fabaceae, Cannabaceae and Apiaceae

Boyko

Brygadyrenko

2019

Biosys. divers.

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“…Terminalia glaucescens (T. glauscens) belongs to the Combretaceae family, believed to have anti-malarial activity but little systematic research has been conducted to explore its properties. The plant has been used traditionally to treat pain, dysentery, venereal diseases, coughs, dysmenorrhea, intestinal parasitosis, ulcers, leprosy and malaria [7]. The ethanolic extract has exhibited aldose inhibition plus anti-plasmodial and anticytotoxic effects [8].…”

Section: Introductionmentioning

confidence: 99%

Comparative Anti-malarial and Toxicological Properties of the Stem Bark ‎Extracts of Nauclea latifolia and Terminalia glaucescens Against ‎Plasmodium berghei-infected Mice

Berinyuy

Mann

Kabiru

et al. 2020

IJT

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Background: Anti-plasmodial activities of the methanol stem bark extracts of Nauclea latifolia, and Terminalia glaucescens were investigated in mice infected with Plasmodium berghei. Methods: A total of 24 Plasmodium berghei infected (P. berghei infected) mice were divided into 8 groups of 3 each. Groups A-F were given 100, 300 or 500 mg/kg of either extracts. Groups G and H received 2 mL normal saline (negative control) and 5 mg/kg of chloroquine (positive control), respectively. The drugs and extracts were administered orally once daily for five days. Results: Alkaloids and flavonoids were the most and abundant metabolites in the extracts, respectively. The extract of Nauclea latifolia (N. latifolia) and Terminalia glaucescens (T. glauscecens) had Median Lethal Dose LD50 of >5000 mg/kg and 3808 mg/kg, respectively. In vivo anti-plasmodial studies revealed that the highest suppression (66.79% and 65.37%) and mean survival days (27.67±1.45 and 30.33±0.33) were recorded for the groups treated with 500 mg/kg N. latifolia or T. glaucescens, respectively. The infected but untreated groups survived only for 9.33±0.88 days while chloroquine treated groups lived for 31.33±0.88 days. The body weight and Packed Cell Volume (PCV) of rats treated with 500 mg/kg. N. latifolia or T. glaucescens significantly increased (P<0.05) compared to those in the infected but untreated groups. There was a significant loss (P<0.05) in body weight and PCV of the mice treated with 100 mg/kg of T. glaucescens compared to those in other treated groups. Conclusion: The extracts exhibited anti-plasmodial activities in mice, therefore, they may be considered potential candidates for new anti-malarial agents.

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Medicinal plant extracts and nematode control.

Chagas

2015

CABI Reviews

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Several aspects should be taken into consideration in relation to the use of active botanical extracts or compounds in parasite control: extraction, conservation, phytochemical study, determination of lethal concentration in vitro, toxicity to the host, effective dose in vivo, residual period, stability, residues/metabolites generated and costs. The in vitro tests that have been used to screen biological activity were developed to detect parasite resistance to anthelmintics. In this way, the effects of a potent plant extract can be underestimated or dismissed if the selected methods disregard some factors that can influence the results, such as solubility or an indirect effect on the nematode. Despite this, the development of strategies that are less dependent on in vivo testing is important. There is a need for fuller investigations not restricted only to indicating whether or not a phytotherapy was effective against parasites. The divergence between efficacy in vitro and inefficacy in vivo can be attributed to key factors related to bioavailability as well as pharmacology of the botanical substances in the host organism. It is important to focus studies to determinate the most appropriate adjuvants and to develop formulation models that can be adapted according to the nature of the plant extract or bioactive compound isolated, to serve as starting points for the development of semi-synthetic and synthetic substances.

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In vivo Anthelmintic Activity of Terminalia glaucescens (Combretaceae) Extracts against Gastrointestinal Nematodes of Sheep

Cited by 4 publications

References 0 publications

Nematocidial activity of aqueous solutions of plants of the families Cupressaceae, Rosaceae, Asteraceae, Fabaceae, Cannabaceae and Apiaceae

Nematocidial activity of aqueous solutions of plants of the families Cupressaceae, Rosaceae, Asteraceae, Fabaceae, Cannabaceae and Apiaceae

Comparative Anti-malarial and Toxicological Properties of the Stem Bark ‎Extracts of Nauclea latifolia and Terminalia glaucescens Against ‎Plasmodium berghei-infected Mice

Medicinal plant extracts and nematode control.

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